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View Structure Prediction Details

Protein: UPC2
Organism: Saccharomyces cerevisiae
Length: 913 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for UPC2.

Description E-value Query
Range
Subject
Range
UPC2 - Sterol regulatory element binding protein, induces transcription of sterol biosynthetic genes and of...
UPC2_YEAST - Sterol uptake control protein 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=UPC2 PE=...
gi|151942193 - gi|151942193|gb|EDN60549.1| transcription factor [Saccharomyces cerevisiae YJM789]
0.0 [1..913] [1..913]
gi|85103181 - gi|85103181|ref|XP_961462.1| hypothetical protein NCU03686 [Neurospora crassa OR74A]
gi|16944558, gi|... - gi|32404750|ref|XP_322988.1| hypothetical protein [Neurospora crassa N150], gi|28923008|gb|EAA32226....
6.0E-63 [605..760] [102..244]
gi|8218220 - gi|8218220|emb|CAB52588.2| PRO1 protein [Sordaria macrospora]
1.0E-53 [8..268] [7..275]
gi|7688277 - gi|7688277|emb|CAB89829.1| PRO1 protein [Sordaria brevicollis]
2.0E-50 [8..268] [7..276]
gi|2262187 - gi|2262187|gb|AAB63563.1| FacB [Aspergillus niger]
4.0E-50 [38..331] [11..334]

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Predicted Domain #1
Region A:
Residues: [1-166]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEVGIQNHK KAVTKPRRRE KVIELIEVDG KKVSTTSTGK RKFHNKSKNG CDNCKRRRVK  60
   61 CDEGKPACRK CTNMKLECQY TPIHLRKGRG ATVVKYVTRK ADGSVESDSS VDLPPTIKKE 120
  121 QTPFNDIQSA VKASGSSNDS FPSSASTTKS ESEEKSSAPI EDKNNM

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 46.502279
Match: 1pyiA_
Description: PPR1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 0.226078362275538 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [167-645]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TPLSMGLQGT INKKDMMNNF FSQNGTIGFG SPERLNSGID GLLLPPLPSG NMGAFQLQQQ  60
   61 QQVQQQSQPQ TQAQQASGTP NERYGSFDLA GSPALQSTGM SLSNSLSGML LCNRIPSGQN 120
  121 YTQQQLQYQL HQQLQLQQHQ QVQLQQYQQL RQEQHQQVQQ QQQEQLQQYQ QHFLQQQQQV 180
  181 LLQQEQQPND EEGGVQEENS KKVKEGPLQS QTSETTLNSD AATLQADALS QLSKMGLSLK 240
  241 SLSTFPTAGI GGVSYDFQEL LGIKFPINNG NSRATKASNA EEALANMQEH HERAAASVKE 300
  301 NDGQLSDTKS PAPSNNAQGG SASIMEPQAA DAVSTMAPIS MIERNMNRNS NISPSTPSAV 360
  361 LNDRQEMQDS ISSLGNLTKA ALENNEPTIS LQTSQTENED DASRQDMTSK INNEADRSSV 420
  421 SAGTSNIAKL LDLSTKGNLN LIDMKLFHHY CTKVWPTITA AKVSGPEIWR DYIPELAFD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [646-794]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YPFLMHALLA FSATHLSRTE TGLEQYVSSH RLDALRLLRE AVLEISENNT DALVASALIL  60
   61 IMDSLANASG NGTVGNQSLN SMSPSAWIFH VKGAATILTA VWPLSERSKF HNIISVDLSD 120
  121 LGDVINPDVG TITELVCFDE SIADLYPVG

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [795-913]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LDSPYLITLA YLDKLHREKN QGDFILRVFT FPALLDKTFL ALLMTGDLGA MRIMRSYYKL  60
   61 LRGFATEVKD KVWFLEGVTQ VLPQDVDEYS GGGGMHMMLD FLGGGLPSMT TTNFSDFSL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.932 0.078 sterol biosynthetic process a.118.8 TPR-like

Predicted Domain #5
Region A:
Residues: [757-913]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NIISVDLSDL GDVINPDVGT ITELVCFDES IADLYPVGLD SPYLITLAYL DKLHREKNQG  60
   61 DFILRVFTFP ALLDKTFLAL LMTGDLGAMR IMRSYYKLLR GFATEVKDKV WFLEGVTQVL 120
  121 PQDVDEYSGG GGMHMMLDFL GGGLPSMTTT NFSDFSL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.932 a.118.8 TPR-like


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