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View Structure Prediction Details

Protein: EKI1
Organism: Saccharomyces cerevisiae
Length: 534 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for EKI1.

Description E-value Query
Range
Subject
Range
EKI1 - Ethanolamine kinase, primarily responsible for phosphatidylethanolamine synthesis via the CDP-ethano...
EKI1_YEAST - Ethanolamine kinase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=EKI1 PE=1 SV=1
0.0 [1..534] [1..534]
gi|186659525, gi... - gi|55960796|emb|CAI16602.1| ethanolamine kinase 2 [Homo sapiens], gi|186659525|ref|NP_060678.2| etha...
2.0E-94 [22..480] [2..386]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
6.0E-92 [54..474] [68..449]
gi|220710, gi|51... - gi|8393107|ref|NP_058823.1| choline kinase alpha [Rattus norvegicus], pir||A42672 choline kinase (EC...
6.0E-82 [100..470] [70..430]
EKI1_MOUSE - Ethanolamine kinase 1 (Fragment) OS=Mus musculus GN=Etnk1 PE=2 SV=1
6.0E-80 [94..480] [65..412]

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Predicted Domain #1
Region A:
Residues: [1-98]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYTNYSLTSS DAMPRTYLVG TASPEMSKKK RQSANCDKPT RRVIHIIDTN EHSEVDLKNE  60
   61 LPITCTNEDG EMTSSSWTSQ TANDFLKLAY VNAKLDPS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.613 0.869 cytoplasm b.55.1 PH domain-like

Predicted functions:

Term Confidence Notes
phosphotransferase activity, alcohol group as acceptor 2.56238090010785 bayes_pls_golite062009
binding 2.55015378442547 bayes_pls_golite062009
protein kinase activity 2.44081222683977 bayes_pls_golite062009
kinase activity 2.34459475289562 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.95139794143606 bayes_pls_golite062009
transferase activity 1.80001061545783 bayes_pls_golite062009
protein serine/threonine kinase activity 1.55379052459468 bayes_pls_golite062009
lipid kinase activity 1.3504796246251 bayes_pls_golite062009
catalytic activity 1.21655087018101 bayes_pls_golite062009
choline kinase activity 1.18757364210199 bayes_pls_golite062009
protein binding 1.12583111976692 bayes_pls_golite062009
phosphoinositide 3-kinase activity 1.10484220525143 bayes_pls_golite062009
1-phosphatidylinositol-3-kinase activity 1.04034573968654 bayes_pls_golite062009
inositol or phosphatidylinositol kinase activity 0.97254836668426 bayes_pls_golite062009
ethanolamine kinase activity 0.68804237112665 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [99-178]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPSQYFKQDI INVLQSLEIP GWSVPGSKES SLNKNLLTLT QIKGALTNVI YKIHYPNLPP  60
   61 LLMRIFGDSI DSVIDREYEL 

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [192-205]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KLEGFFENGR FEKY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2.522879
Match: 1j7iA_
Description: Type IIIa 3',5"-aminoglycoside phosphotransferase
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [179-191]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KVIARLSFYD LGP

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [206-447]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IEGSRTSTQA DFIDRDTSIK IAKKLKELHC TVPLTHKEIT DQPSCWTTFD QWIKLIDSHK  60
   61 EWVSNNVNIS ENLRCSSWNF FLKSFKNYKR WLYNDSAFTS KLLREDDKDS MINSGLKMVF 120
  121 CHNDLQHGNL LFKSKGKDDI SVGDLTIIDF EYAGPNPVVF DLSNHLNEWM QDYNDVQSFK 180
  181 SHIDKYPKEE DILVFAQSYI NHMNENHVKI ASQEVRILYN LIIEWRPCTQ LFWCLWALLQ 240
  241 SG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2.522879
Match: 1j7iA_
Description: Type IIIa 3',5"-aminoglycoside phosphotransferase
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [448-534]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RLPQRPLIEG EKLMSEKAGL GDETHLMEHK NKENGKYDCS EDDSFNYLGF CKEKMSVFWG  60
   61 DLITLGVIDK DCPDIGKTDY LDTKLIF

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle