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View Structure Prediction Details

Protein: MKC7
Organism: Saccharomyces cerevisiae
Length: 596 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MKC7.

Description E-value Query
Range
Subject
Range
MKC7 - GPI-anchored aspartyl protease (yapsin) involved in protein processing; shares functions with Yap3p ...
MKC7_YEAST - Aspartic proteinase MKC7 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MKC7 PE=1 SV=2
0.0 [1..596] [1..596]
gi|28603728, gi|... - gi|6224889|gb|AAF05999.1|AF192333_1 pregnancy-associated glycoprotein-16 [Bos taurus], gi|28603728|r...
0.0 [110..470] [44..379]
PEPA_CANLF - Pepsin A OS=Canis lupus familiaris GN=PGA PE=2 SV=1
1.0E-98 [1..470] [1..385]
gi|6180007 - gi|6180007|gb|AAF05750.1|AF191336_1 pregnancy-associated glycoprotein-11 [Capra hircus]
1.0E-98 [114..470] [48..379]
gi|12053845, gi|... - gi|18858489|ref|NP_571785.1| cathepsin D [Danio rerio], gi|12053845|emb|CAC20111.1| cathepsin D enzy...
9.0E-97 [99..471] [35..397]

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Predicted Domain #1
Region A:
Residues: [1-144]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKLSVLTFVV DALLVCSSIV DAGVTDFPSL PSNEVYVKMN FQKKYGSSFE NALDDTKGRT  60
   61 RLMTRDDDYE LVELTNQNSF YSVELDIGTP PQKVTVLVDT GSSDLWVTGS DNPYCSTKKK 120
  121 DTTGSSFKQV NKDALASVVE SVFT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 75.512579
Match: 1lcgA_
Description: No description for 1lcgA_ was found.

Predicted Domain #2
Region A:
Residues: [145-276]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EISYDTTIVT SEATATFDST ASTSQLIDCA TYGTFNTSKS STFNSNNTEF SIAYGDTTFA  60
   61 SGTWGHDQLS LNDLNITGLS FAVANETNST VGVLGIGLPG LESTYSGVSL SSVQKSYTYN 120
  121 NFPMVLKNSG VI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 800.927757
Match: 1ypsA_
Description: No description for 1ypsA_ was found.

Predicted functions:

Term Confidence Notes
aspartic-type endopeptidase activity 7.28637514153772 bayes_pls_golite062009
aspartic-type peptidase activity 7.28637514153772 bayes_pls_golite062009
peptidase activity 5.78181196721293 bayes_pls_golite062009
endopeptidase activity 5.4888481808613 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 5.39972232367526 bayes_pls_golite062009
hydrolase activity 3.97352810629953 bayes_pls_golite062009
catalytic activity 1.54514410489082 bayes_pls_golite062009
binding 0.902062095182608 bayes_pls_golite062009
receptor binding 0.772960860414817 bayes_pls_golite062009
drug binding 0.177583989372323 bayes_pls_golite062009
protein binding 0.094081389440774 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [277-313]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KSTAYSLFAN DSDSKHGTIL FGAVDHGKYA GDLYTIP

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [453-495]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NTYVVYDLDN MEISMAQANF SDDGEYIEII ESAVPSALKA PGY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 800.927757
Match: 1ypsA_
Description: No description for 1ypsA_ was found.

Predicted Domain #4
Region A:
Residues: [314-452]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IINTLQHRGY KDPIQFQVTL QGLGTSKGDK EDNLTTLTTT KIPVLLDSGT TISYMPTELV  60
   61 KMLADQVGAT YSSAYGYYIM DCIKEMEEES SIIFDFGGFY LSNWLSDFQL VTDSRSNICI 120
  121 LGIAPQSDPT IILGDNFLA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 800.927757
Match: 1ypsA_
Description: No description for 1ypsA_ was found.

Predicted Domain #5
Region A:
Residues: [496-596]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSTWSTYESI VSGGNMFSTA ANSSISYFAS TSHSATSSSS SKGQKTQTST TALSISKSTS  60
   61 STSSTGMLSP TSSSSTRKEN GGHNLNPPFF ARFITAIFHH I

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle