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View Structure Prediction Details

Protein: TMA64
Organism: Saccharomyces cerevisiae
Length: 565 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TMA64.

Description E-value Query
Range
Subject
Range
TMA64_YEAST - Translation machinery-associated protein 64 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c)...
gi|190404922 - gi|190404922|gb|EDV08189.1| conserved hypothetical protein [Saccharomyces cerevisiae RM11-1a]
TMA64 - Protein of unknown function that associates with ribosomes; has a putative RNA binding domain
0.0 [1..557] [1..557]
gi|7678701 - gi|7678701|gb|AAF34185.2| hepatocellular carcinoma-associated antigen 56; HCA56 [Homo sapiens]
0.0 [1..565] [1..583]
EIF2D_MOUSE - Eukaryotic translation initiation factor 2D OS=Mus musculus GN=Eif2d PE=1 SV=3
0.0 [1..565] [1..570]
gi|220954770, gi... - gi|220954770|gb|ACL89928.1| ligatin-PA [synthetic construct], gi|220944938|gb|ACL85012.1| ligatin-PA...
ligatin-PA - The gene ligatin is referred to in FlyBase by the symbol Dmel\ligatin (CG31426, FBgn0041588). It is ...
0.0 [1..559] [1..554]
CE29676 - status:Partially_confirmed UniProt:Q18186 protein_id:AAK31455.3
0.0 [1..564] [1..516]

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Predicted Domain #1
Region A:
Residues: [1-59]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFKKEPHIKA LSNLKNSERK KLLQTFQKQT NNEEYSFRTS TIKQTNFNGQ KSVGTVYTD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.69897
Match: 1k8wA_
Description: Pseudouridine synthase II TruB, C-terminal domain; Pseudouridine synthase II TruB
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [60-193]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ENNTPILFKE KHKEQLFPTV YSCWEYPALL PIVLTHGFVI EEHLFNGANL MISGSIPPFD  60
   61 PRCKIGTLCG IASKQAPETV LAIGIVELDL PSFDKVIGET GVAVKIIHHF NDGLSKVFKM 120
  121 KLEPPFVLST QSKD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 12.30103
Match: 1it7A_
Description: Archaeosine tRNA-guanine transglycosylase, C3 domain; Archaeosine tRNA-guanine transglycosylase, N-terminal domain; Archaeosine tRNA-guanine transglycosylase, C2 domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [194-436]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NNISSKQIES SEQIKAVEKE QEDVKEASVD VEEIAEVLDH FTVSDVDYFI TRALYYTLTQ  60
   61 DKGLELPISA SNFISNHIMR NLPPIDHNEV NVKKTSWKKS AKFLKHFEKE GFLKLKGKGD 120
  121 DLTIVGKNTD KDELKNFVPY KLGCSKSATE SRESTTSKEK TSGMMYSLTL YKPFNLAKDL 180
  181 LKEVNLASHT YYTSQDIRSA VSQYISVKNL ADTKDKGKVI MDDLLFDMVN KKKKVLNASR 240
  241 IIA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [437-565]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RGEILHPLLT NNFTEFYQIF KSDDTLLFKA PMKGSLPHIK IITEMKIGRK VITRVSNFEV  60
   61 FQVDPESLAA DLRKICSGST TISESQTFKC AEVQVQGPHG QSIIDHLNKL GIPSKWIDFE 120
  121 NKLKKKKRK

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 10.0
Match: 1d1rA
Description: YciH
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 0.578545460864021 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle