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View Structure Prediction Details

Protein: PDC2
Organism: Saccharomyces cerevisiae
Length: 925 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PDC2.

Description E-value Query
Range		 Subject
Range
PDC2_YEAST - Protein PDC2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PDC2 PE=1 SV=2
PDC2 - Transcription factor required for the synthesis of the glycolytic enzyme pyruvate decarboxylase, req...
 0.0 [1..925] [1..925]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [2..736] [3..765]
PDC2_CANAX - Protein PDC2 OS=Candida albicans GN=PDC2 PE=3 SV=1
 0.0 [3..584] [4..642]
cbh2 - centromere binding protein Cbh2
CBH2_SCHPO - CENP-B homolog protein 2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=cbh2 PE=3 SV=1
 0.0 [2..483] [9..454]
TIGD6 - tigger transposable element derived 6
 2.0E-98 [3..536] [13..473]
gi|2501794 - gi|2501794|gb|AAB80698.1| Cbhp [Schizosaccharomyces pombe]
 3.0E-97 [3..506] [9..474]

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Predicted Domain #1
Region A:
Residues: [1-68] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLSIQQRYNI CLMAERHPKW TQLELAKWAY ETFQLPKIPS QGTISRLLAR KSTYMNCKEH  60
   61 EKDANRLR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 72.69897
Match: 1iufA_
Description: Ars-binding protein 1, ABP1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.41876985649951 bayes_pls_golite062009
nucleic acid binding 4.09724849396574 bayes_pls_golite062009
transcription factor activity 3.86239731611043 bayes_pls_golite062009
binding 3.55096238224843 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.16896789933192 bayes_pls_golite062009
sequence-specific DNA binding 2.32406445003946 bayes_pls_golite062009
transcription repressor activity 1.91962622287073 bayes_pls_golite062009
transcription activator activity 1.77700860354597 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.73068440195944 bayes_pls_golite062009
chromatin binding 1.50301355818265 bayes_pls_golite062009
protein binding 1.44503155604344 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
transcription corepressor activity 0.12996981272574 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [69-148] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KPNNLLVRKI LQEWISQSLW NGIPITSPII QDTAQAVWHR IPAEHREGNG SFSYKWISNF  60
   61 LSKMDVNISV LDEELPKTPK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 72.69897
Match: 1iufA_
Description: Ars-binding protein 1, ABP1
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [149-432] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VWTFEERDVL KAYFSKIPPK DLFTLDEAFL SYNLPLDYAQ YEASSIQRRI EVATVMLCSN  60
   61 LDGSEKLKPV VVGKYDSYKS FRNYFPNEPN DPVSQSMLGT KMAKKFDISY HSNRKAWLTS 120
  121 NLFHNWLVRW DKRLVAVNRK IWIVLDDSCC HRIINLRLQN IKLVYTSSNS KFLPFNWGVW 180
  181 DEFKTRYRIQ QYQALIDLQN RISKNIQNKN KSERNECIPN GKKCLISFEQ SQLTMSNAFK 240
  241 FIKKAWDDIP VDAIKANWKS SGLLPPEMIH LNENVSMAFK KNEV

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 127.119186
Match: PF03184
Description: DDE superfamily endonuclease

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [433-804] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LESVLNRLCD EYYCVKKWEY EMLLDLNIEN KNTNFLSTEE LVESAIVEPC EPDFDTAPKG  60
   61 NEVHDDNFDV SVFANEDDNN QNHLSMSQAS HNPDYNSNHS NNAIENTNNR GSNNNNNNNG 120
  121 SSNNINDNDS SVKYLQQNTV DNSTKTGNPG QPNISSMESQ RNSSTTDLVV DGNYDVNFNG 180
  181 LLNDPYNTMK QPGPLDYNVS TLIDKPNLFL SPDLDLSTVG VDMQLPSSEY FSEVFSSAIR 240
  241 NNEKAASDQN KSTDELPSST AMANSNSITT ALLESRNQAQ PFDVPHMNGL LSDTSKSGHS 300
  301 VNSSNAISQN SLNNFQHNSA SVAEASSPSI TPSPVAINST GAPARSIISA PIDSNSSASS 360
  361 PSALEHLEGA VS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [805-925] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GMSPSSTTIL SNLQTNINIA KSLSTIMKHA ESNEISLTKE TINELNFNYL TLLKRIKKTR  60
   61 KQLNSESIKI NSKNAQDHLE TLLSGAAAAA ATSANNLDLP TGGSNLPDSN NLHLPGNTGF 120
  121 F

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score		 GO
Score		 GO
Term		 SCOP
Match		 SCOP Description
View Download 0.888 0.006 glucose catabolic process to ethanol a.7.2 Enzyme IIa from lactose specific PTS, IIa-lac

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle