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View Structure Prediction Details

Protein: TPS2
Organism: Saccharomyces cerevisiae
Length: 896 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TPS2.

Description E-value Query
Range
Subject
Range
gi|406769 - gi|406769|emb|CAA50025.1| trehalose-6-phosphate phosphatase [Saccharomyces cerevisiae]
0.0 [1..896] [1..896]
gi|8886767 - gi|8886767|gb|AAF80562.1|AF208030_1 trehalose-6-phosphate phosphatase [Zygosaccharomyces rouxii]
0.0 [8..891] [3..898]
gi|11557981 - gi|11557981|emb|CAC17748.1| trehalose-6-phosphate phosphatase [Candida albicans]
gi|46443174, gi|... - gi|68469504|ref|XP_721265.1| hypothetical protein CaO19.10556 [Candida albicans SC5314], gi|68468955...
gi|238879186 - gi|238879186|gb|EEQ42824.1| trehalose-phosphatase [Candida albicans WO-1]
0.0 [4..890] [10..873]
TPS9_ARATH - Probable alpha,alpha-trehalose-phosphate synthase [UDP-forming] 9 OS=Arabidopsis thaliana GN=TPS9 PE...
0.0 [3..884] [48..867]
gi|19568935 - gi|19568935|gb|AAL91978.1|AF483209_1 putative trehalose synthase [Solanum tuberosum]
0.0 [2..863] [49..856]
gi|113533672, gi... - gi|34910846|ref|NP_916770.1| putative trehalose-6-phosphate synthase [Oryza sativa (japonica cultiva...
0.0 [2..860] [65..869]

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Predicted Domain #1
Region A:
Residues: [1-120]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTTAQDNSP KKRQRIINCV TQLPYKIQLG ESNDDWKISA TTGNSALFSS LEYLQFDSTE  60
   61 YEQHVVGWTG EITRTERNLF TREAKEKPQD LDDDPLYLTK EQINGLTTTL QDHMKSDKEA 120
  121 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity 11.2045941324603 bayes_pls_golite062009
glucosyltransferase activity 8.25064561355471 bayes_pls_golite062009
UDP-glucosyltransferase activity 8.0463972704113 bayes_pls_golite062009
trehalose-phosphatase activity 7.58500038184065 bayes_pls_golite062009
transferase activity, transferring hexosyl groups 3.70184884300914 bayes_pls_golite062009
catalytic activity 2.65148466065976 bayes_pls_golite062009
transferase activity, transferring glycosyl groups 2.62403914335522 bayes_pls_golite062009
transferase activity 2.18054407163329 bayes_pls_golite062009
UDP-glycosyltransferase activity 2.13085705769565 bayes_pls_golite062009
binding 0.86799881302731 bayes_pls_golite062009
carbohydrate phosphatase activity 0.78952375993773 bayes_pls_golite062009
UDP-N-acetylglucosamine 2-epimerase activity 0.690032302126686 bayes_pls_golite062009
glycogen phosphorylase activity 0.607220464589157 bayes_pls_golite062009
phosphorylase activity 0.296436712681472 bayes_pls_golite062009
mannosyltransferase activity 0.253888301381021 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [121-317]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KTDTTQTAPV TNNVHPVWLL RKNQSRWRNY AEKVIWPTFH YILNPSNEGE QEKNWWYDYV  60
   61 KFNEAYAQKI GEVYRKGDII WIHDYYLLLL PQLLRMKFND ESIIIGYFHH APWPSNEYFR 120
  121 CLPRRKQILD GLVGANRICF QNESFSRHFV SSCKRLLDAT AKKSKNSSNS DQYQVSVYGG 180
  181 DVLVDSLPIG VNTTQIL

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [524-545]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EVPTIQDWTN KFLSSLKEQA SS

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 13.39
Match: 1f6dA
Description: UDP-N-acetylglucosamine 2-epimerase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
trehalose-phosphatase activity 3.78859922218487 bayes_pls_golite062009
catalytic activity 1.55296860681783 bayes_pls_golite062009
binding 0.54369553186176 bayes_pls_golite062009
hydrolase activity 0.385402333062566 bayes_pls_golite062009
nucleic acid binding 0.263520144636139 bayes_pls_golite062009
phosphatase activity 0.159899259988948 bayes_pls_golite062009
phosphoric ester hydrolase activity 0.103902756538853 bayes_pls_golite062009
DNA binding 0.0142681844140111 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [318-523]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KDAFTKDIDS KVLSIKQAYQ NKKIIIGRDR LDSVRGVVQK LRAFETFLAM YPEWRDQVVL  60
   61 IQVSSPTANR NSPQTIRLEQ QVNELVNSIN SEYGNLNFSP VQHYYMRIPK DVYLSLLRVA 120
  121 DLCLITSVRD GMNTTALEYV TVKSHMSNFL CYGNPLILSE FSGSSNVLKD AIVVNPWDSV 180
  181 AVAKSINMAL KLDKEEKSNL ESKLWK

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 13.39
Match: 1f6dA
Description: UDP-N-acetylglucosamine 2-epimerase
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [546-896]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NDDMERKMTP ALNRPVLLEN YKQAKRRLFL FDYDGTLTPI VKDPAAAIPS ARLYTILQKL  60
   61 CADPHNQIWI ISGRDQKFLN KWLGGKLPQL GLSAEHGCFM KDVSCQDWVN LTEKVDMSWQ 120
  121 VRVNEVMEEF TTRTPGSFIE RKKVALTWHY RRTVPELGEF HAKELKEKLL SFTDDFDLEV 180
  181 MDGKANIEVR PRFVNKGEIV KRLVWHQHGK PQDMLKGISE KLPKDEMPDF VLCLGDDFTD 240
  241 EDMFRQLNTI ETCWKEKYPD QKNQWGNYGF YPVTVGSASK KTVAKAHLTD PQQVLETLGL 300
  301 LVGDVSLFQS AGTVDLDSRG HVKNSESSLK SKLASKAYVM KRSASYTGAK V

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle