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View Structure Prediction Details

Protein: AAD4
Organism: Saccharomyces cerevisiae
Length: 329 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for AAD4.

Description E-value Query
Range
Subject
Range
ALKR4_ARATH - Probable aldo-keto reductase 4 OS=Arabidopsis thaliana GN=At1g60710 PE=2 SV=1
4.0E-94 [5..327] [38..344]
AAD4_YEAST - Probable aryl-alcohol dehydrogenase AAD4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN...
AAD4 - Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase, ...
2.0E-91 [1..329] [1..329]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
2.0E-87 [5..327] [35..338]
gi|7471099 - pir||E75296 aldo/keto reductase - Deinococcus radiodurans (strain R1)
gi|15807252, gi|... - gi|6460065|gb|AAF11806.1|AE002058_6 aldo/keto reductase [Deinococcus radiodurans R1], gi|15807252|re...
2.0E-86 [2..303] [29..319]

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Predicted Domain #1
Region A:
Residues: [1-329]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGSMNKEQAF ELLDAFYEAG GNCIDTANSY QNEESEIWIG EWMKSRKLRD QIVIATKFTG  60
   61 DYKKYEVGGG KSANYCGNHK HSLHVSVRDS LRKLQTDWID ILYVHWWDYM SSIEEVMDSL 120
  121 HILVQQGKVL YLGVSDTPAW VVSAANYYAT SHGKTPFSIY QGKWNVLNRD FERDIIPMAR 180
  181 HFGMALAPWD VMGGGRFQSK KAMEERKKNG EGLRTVSGTS KQTDKEVKIS EALAKVAEEH 240
  241 GTESVTAIAI AYVRSKAKNV FPLVGGRKIE HLKQNIEALS IKLTPEQIEY LESIIPFDVG 300
  301 FPTNFIGDDP AVTKKASLLT AMSAQISFD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 217.69897
Match: 1gveB_
Description: Aflatoxin aldehyde reductase (akr7a1)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
aldo-keto reductase activity 2.57303336304449 bayes_pls_golite062009
aryl-alcohol dehydrogenase activity 2.5168190536972 bayes_pls_golite062009
catalytic activity 1.68179794468736 bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors 1.48881830724998 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1.47641884930911 bayes_pls_golite062009
binding 1.3044513338497 bayes_pls_golite062009
aldehyde reductase activity 1.16639404121425 bayes_pls_golite062009
protein binding 0.013141318464947 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle