YRC Public Data Repository - Protein Structure Prediction

Protein:	NUS1
Organism:	Saccharomyces cerevisiae
Length:	375 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NUS1.

Description	E-value	Query Range	Subject Range
UPPS_YEAST - Dehydrodolichyl diphosphate syntase complex subunit NUS1 OS=Saccharomyces cerevisiae (strain ATCC 20... NUS1 - Putative prenyltransferase, required for cell viability; proposed to be involved in protein traffick...	0.0	[1..375]	[1..375]
ISPT1_NOSS1 - Isoprenyl transferase 1 OS=Nostoc sp. (strain PCC 7120 / UTEX 2576) GN=uppS1 PE=3 SV=1 gi\|25314096 - pir\|\|AD2180 undecaprenyl pyrophosphate synthetase [imported] - Nostoc sp. (strain PCC 7120)	7.0E-84	[147..375]	[15..248]
UPPS_PYRHO - Undecaprenyl pyrophosphate synthase OS=Pyrococcus horikoshii GN=uppS PE=3 SV=1 UPPS_PYRHO - Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific) OS=Pyrococc...	4.0E-81	[123..375]	[4..264]
UPPS_PYRAB - Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific) OS=Pyrococc... UPPS_PYRAB - Undecaprenyl pyrophosphate synthase OS=Pyrococcus abyssi GN=uppS PE=3 SV=1	4.0E-81	[124..375]	[5..264]
UPPS_METJA - Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific) OS=Methanoc... UPPS_METJA - Undecaprenyl pyrophosphate synthase OS=Methanocaldococcus jannaschii GN=uppS PE=3 SV=1	4.0E-80	[119..375]	[2..280]
UPPS_METTH - Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific) OS=Methanot... gi\|7447505 - gi\|7447505\|pir\|\|H69128 conserved hypothetical protein MTH232 - Methanobacterium thermoautotrophicum ...	7.0E-80	[132..374]	[10..254]
gi\|170714048, gi... - gi\|170714048\|gb\|EDT26230.1\| undecaprenyl diphosphate synthase [Clostridium perfringens CPE str. F496... gi\|110676017, gi... - gi\|110801370\|ref\|YP_696383.1\| undecaprenyl diphosphate synthase [Clostridium perfringens ATCC 13124]... gi\|182380984, gi... - gi\|182380984\|gb\|EDT78463.1\| undecaprenyl diphosphate synthase [Clostridium perfringens NCTC 8239], g... ISPT_CLOPE - Isoprenyl transferase OS=Clostridium perfringens (strain 13 / Type A) GN=uppS PE=3 SV=1 gi\|169299227, gi... - gi\|169342721\|ref\|ZP_02863762.1\| undecaprenyl diphosphate synthase [Clostridium perfringens C str. JG... gi\|177907477, gi... - gi\|182627140\|ref\|ZP_02954855.1\| undecaprenyl diphosphate synthase [Clostridium perfringens D str. JG... gi\|110803535, gi... - gi\|110803535\|ref\|YP_698983.1\| undecaprenyl diphosphate synthase [Clostridium perfringens SM101], gi\|... gi\|168208113, gi... - gi\|170660606\|gb\|EDT13289.1\| undecaprenyl diphosphate synthase [Clostridium perfringens E str. JGS198... UPPS_CLOPE - Undecaprenyl pyrophosphate synthase OS=Clostridium perfringens GN=uppS PE=3 SV=1 gi\|170710581, gi... - gi\|170710581\|gb\|EDT22763.1\| undecaprenyl diphosphate synthase [Clostridium perfringens B str. ATCC 3...	8.0E-80	[146..374]	[17..250]
ISPT_SYNY3 - Isoprenyl transferase OS=Synechocystis sp. (strain PCC 6803 / Kazusa) GN=uppS PE=3 SV=1 UPPS_SYNY3 - Undecaprenyl pyrophosphate synthase OS=Synechocystis sp. (strain ATCC 27184 / PCC 6803 / N-1) GN=upp... gi\|7447507 - pir\|\|S75982 hypothetical protein sll0506 - Synechocystis sp. (strain PCC 6803)	2.0E-79	[147..375]	[15..248]
UPPS_PYRFU - Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific) OS=Pyrococc... UPPS_PYRFU - Undecaprenyl pyrophosphate synthase OS=Pyrococcus furiosus GN=uppS PE=3 SV=1	5.0E-79	[123..375]	[4..264]

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Predicted Domain #1

Region A:
Residues: [1-78]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPTMIKKDDK AMEPPNEKPH RKIERDDVPE SSNHIPPPES GVLKGGKVNS KTRALKAVTS  60
   61 IIADADENPQ KKVNNETN

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [79-375]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GVQKQKTEDL SKRIGKFEYL FYKFLLVLLY ICFGLFRYGQ YQYNKMKLRI FSIIYNHAYT  60
   61 PQLIRQDVIP LKKIPKRLAA ILEVKPVGDV GGGVTGLLND ASEIVCWTVS AGIKHLMLYD 120
  121 YDGILQRNVP ELRMEIHSNL AKYFGPAHVP NYAVKIPHSN KIFYNLDGIE TETDVGNEIE 180
  181 ANQEKDKIAI EISLLSNRDG RETIVDLTKT MAELCAVNEL SVSDITMDLV DSELKQLVGP 240
  241 EPDLLLYFGP SLDLQGFPPW HIRLTEFYWE KDNNEVIYSV FIRGLRQYAG CKVNVGK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	77.154902
Match:	1f75A_
Description:	Undecaprenyl diphosphate synthase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
dehydrodolichyl diphosphate synthase activity	2.65131914933987	bayes_pls_golite062009
transferase activity	1.42376896518855	bayes_pls_golite062009
di-trans,poly-cis-decaprenylcistransferase activity	1.40194046037281	bayes_pls_golite062009
prenyltransferase activity	1.2102902082955	bayes_pls_golite062009
binding	1.17686415104256	bayes_pls_golite062009
catalytic activity	0.878978773660153	bayes_pls_golite062009
protein binding	0.331797220769091	bayes_pls_golite062009
transferase activity, transferring alkyl or aryl (other than methyl) groups	0.256467886977999	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: