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View Structure Prediction Details

Protein: UGA3
Organism: Saccharomyces cerevisiae
Length: 528 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for UGA3.

Description E-value Query
Range
Subject
Range
UGA3_YEAST - Transcriptional activator protein UGA3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=U...
UGA3 - Transcriptional activator necessary for gamma-aminobutyrate (GABA)-dependent induction of GABA genes...
0.0 [1..528] [1..528]
YCUA_SCHPO - Uncharacterized transcriptional regulatory protein C965.10 OS=Schizosaccharomyces pombe (strain 972 ...
SPCC965.10 - transcription factor
0.0 [9..526] [13..522]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
1.0E-51 [2..268] [76..315]
gi|7688277 - gi|7688277|emb|CAB89829.1| PRO1 protein [Sordaria brevicollis]
6.0E-35 [2..182] [37..214]
gi|8218220 - gi|8218220|emb|CAB52588.2| PRO1 protein [Sordaria macrospora]
7.0E-34 [2..182] [37..213]
PRO1_NEUCR - Transcriptional regulatory protein pro-1 OS=Neurospora crassa GN=pro-1 PE=2 SV=1
PRO1_NEUCR - Transcriptional regulatory protein pro1 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 7...
3.0E-30 [2..182] [38..214]
ALCR_EMENI - Regulatory protein alcR OS=Emericella nidulans GN=alcR PE=1 SV=2
ALCR_EMENI - Regulatory protein alcR OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 ...
2.0E-28 [9..179] [4..209]

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Predicted Domain #1
Region A:
Residues: [1-58]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNYGVEKLKL KYSKHGCITC KIRKKRCSED KPVCRDCRRL SFPCIYISES VDKQSLKK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 32.201249
Match: 1pyiA_
Description: PPR1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.56444258780502 bayes_pls_golite062009
DNA binding 4.26146437716972 bayes_pls_golite062009
nucleic acid binding 4.17369933547911 bayes_pls_golite062009
transcription factor activity 3.049435548132 bayes_pls_golite062009
sequence-specific DNA binding 2.98081393153291 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.93914501897006 bayes_pls_golite062009
binding 2.91929847152301 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 2.44382866473054 bayes_pls_golite062009
transcription activator activity 2.24483536326713 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [59-452]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IKADIQHQLI SKKRKHAPDS AQKAAVATRT RRVGSDEQDN QVYLSKPLED CISQKLDSMG  60
   61 LQLYNYYRSH LANIISIAPM NQNYYLNIFL PMAHENDGIL FAILAWSANH LSISSSNELR 120
  121 KDEIFVNLAN KYTYMSLSHL KTNEGSSACA KLGFLYSLAQ ILILCGSEIC QGDVKFWKIL 180
  181 LNIGKNLIEN HVGKDVSRIL TTTTEEPSLE ERIIFPNFNS VVKYWLIVNF IYHDILNFNT 240
  241 TSFPIEQYEK FFQRDQNSLP SSANFIESID SPIEEIDPLI GINKPILLLL GQVTNLTRFL 300
  301 QTMEQEEMLE HGDKILSLQV EIYKLQPSLM ALEHLDDEKK FYYLELFEIM KISTLMFFQL 360
  361 TLLKIDKDSL ELQILRNKLD SKLDKVIGTF LEGS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [453-528]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LCFPLFIYGV CIQVEDMEKK IDLEAKFDDI LKRYKCYNFQ NARLLIRKIW QNEADGISEH  60
   61 DLVHMIDELD YNINFA

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.888 0.193 regulation of transcription from RNA polymerase II promoter a.74.1 Cyclin-like
View Download 0.730 0.029 nitrogen utilization a.64.1 Saposin
View Download 0.666 0.026 nitrogen utilization a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.622 N/A N/A a.5.6 Hypothetical protein MTH1615
View Download 0.614 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.607 N/A N/A a.64.1 Saposin
View Download 0.558 N/A N/A a.81.1 N-terminal domain of DnaB helicase
View Download 0.504 N/A N/A a.60.13 Putative methyltransferase TM0872, insert domain
View Download 0.478 N/A N/A a.56.1 CO dehydrogenase ISP C-domain like
View Download 0.468 N/A N/A a.56.1 CO dehydrogenase ISP C-domain like
View Download 0.468 N/A N/A a.163.1 Crustacean CHH/MIH/GIH neurohormone
View Download 0.463 N/A N/A a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.459 N/A N/A a.4.13 Sigma3 and sigma4 domains of RNA polymerase sigma factors
View Download 0.455 N/A N/A a.60.13 Putative methyltransferase TM0872, insert domain
View Download 0.451 N/A N/A a.144.1 PABC (PABP) domain
View Download 0.442 N/A N/A a.23.4 Mitochondrial import receptor subunit Tom20
View Download 0.439 N/A N/A a.57.1 Protein HNS-dependent expression A; HdeA
View Download 0.435 N/A N/A a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.426 N/A N/A a.37.1 A DNA-binding domain in eukaryotic transcription factors
View Download 0.419 N/A N/A a.4.1 Homeodomain-like
View Download 0.418 N/A N/A a.48.3 Conserved domain common to transcription factors TFIIS, elongin A, CRSP70
View Download 0.413 N/A N/A a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.412 N/A N/A a.35.1 lambda repressor-like DNA-binding domains
View Download 0.407 N/A N/A d.15.1 Ubiquitin-like
View Download 0.405 N/A N/A a.57.1 Protein HNS-dependent expression A; HdeA
View Download 0.403 N/A N/A a.3.1 Cytochrome c
View Download 0.394 N/A N/A a.126.1 Serum albumin-like
View Download 0.391 N/A N/A a.39.1 EF-hand
View Download 0.391 N/A N/A a.5.6 Hypothetical protein MTH1615
View Download 0.390 N/A N/A a.39.1 EF-hand
View Download 0.389 N/A N/A a.4.1 Homeodomain-like
View Download 0.388 N/A N/A a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.387 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.369 N/A N/A a.56.1 CO dehydrogenase ISP C-domain like
View Download 0.367 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.366 N/A N/A a.126.1 Serum albumin-like
View Download 0.365 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.359 N/A N/A g.39.1 Glucocorticoid receptor-like (DNA-binding domain)
View Download 0.358 N/A N/A a.60.9 lambda integrase-like, N-terminal domain
View Download 0.355 N/A N/A a.144.1 PABC (PABP) domain
View Download 0.349 N/A N/A a.144.1 PABC (PABP) domain
View Download 0.346 N/A N/A a.4.1 Homeodomain-like
View Download 0.344 N/A N/A a.144.1 PABC (PABP) domain
View Download 0.341 N/A N/A a.60.5 Barrier-to-autointegration factor, BAF
View Download 0.338 N/A N/A a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.333 N/A N/A a.8.3 Families 57/38 glycoside transferase middle domain
View Download 0.333 N/A N/A a.4.1 Homeodomain-like
View Download 0.332 N/A N/A d.15.1 Ubiquitin-like
View Download 0.331 N/A N/A a.2.8 Eukaryotic DNA topoisomerase I, dispensable insert domain
View Download 0.331 N/A N/A a.28.2 Colicin E immunity proteins
View Download 0.329 N/A N/A a.35.1 lambda repressor-like DNA-binding domains
View Download 0.326 N/A N/A a.81.1 N-terminal domain of DnaB helicase
View Download 0.325 N/A N/A a.3.1 Cytochrome c
View Download 0.324 N/A N/A a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.321 N/A N/A d.74.2 C-terminal domain of arginine repressor
View Download 0.319 N/A N/A a.51.1 Cytochrome c oxidase subunit h
View Download 0.319 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.310 N/A N/A a.4.1 Homeodomain-like
View Download 0.309 N/A N/A a.60.5 Barrier-to-autointegration factor, BAF
View Download 0.306 N/A N/A a.56.1 CO dehydrogenase ISP C-domain like
View Download 0.305 N/A N/A a.56.1 CO dehydrogenase ISP C-domain like
View Download 0.305 N/A N/A a.112.1 Description not found.
View Download 0.298 N/A N/A a.105.1 FIS-like
View Download 0.296 N/A N/A d.74.2 C-terminal domain of arginine repressor
View Download 0.293 N/A N/A a.4.1 Homeodomain-like
View Download 0.291 N/A N/A a.77.1 DEATH domain
View Download 0.290 N/A N/A a.76.1 Iron-dependent represor protein, dimerization domain
View Download 0.287 N/A N/A a.5.6 Hypothetical protein MTH1615
View Download 0.287 N/A N/A a.5.6 Hypothetical protein MTH1615
View Download 0.287 N/A N/A a.35.1 lambda repressor-like DNA-binding domains
View Download 0.285 N/A N/A a.144.1 PABC (PABP) domain
View Download 0.285 N/A N/A a.5.3 N-terminal domain of phosphatidylinositol transfer protein sec14p
View Download 0.283 N/A N/A a.23.4 Mitochondrial import receptor subunit Tom20
View Download 0.283 N/A N/A a.5.3 N-terminal domain of phosphatidylinositol transfer protein sec14p
View Download 0.281 N/A N/A d.39.1 Dynein light chain 8 (DLC8)
View Download 0.279 N/A N/A a.5.3 N-terminal domain of phosphatidylinositol transfer protein sec14p
View Download 0.278 N/A N/A a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.277 N/A N/A a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.276 N/A N/A a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.275 N/A N/A a.60.13 Putative methyltransferase TM0872, insert domain
View Download 0.267 N/A N/A a.60.9 lambda integrase-like, N-terminal domain
View Download 0.267 N/A N/A a.126.1 Serum albumin-like
View Download 0.262 N/A N/A a.81.1 N-terminal domain of DnaB helicase
View Download 0.262 N/A N/A a.81.1 N-terminal domain of DnaB helicase
View Download 0.259 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.255 N/A N/A a.39.1 EF-hand
View Download 0.255 N/A N/A a.39.1 EF-hand
View Download 0.254 N/A N/A a.4.13 Sigma3 and sigma4 domains of RNA polymerase sigma factors
View Download 0.253 N/A N/A a.77.1 DEATH domain
View Download 0.252 N/A N/A a.35.1 lambda repressor-like DNA-binding domains
View Download 0.247 N/A N/A d.43.1 Elongation factor Ts (EF-Ts), dimerisation domain
View Download 0.241 N/A N/A a.5.7 4-hydroxy-2-oxovalerate aldolase DmpG, communication domain
View Download 0.238 N/A N/A f.34.1 Mechanosensitive channel protein MscS (YggB), transmembrane region
View Download 0.234 N/A N/A a.40.1 Calponin-homology domain, CH-domain
View Download 0.232 N/A N/A a.5.3 N-terminal domain of phosphatidylinositol transfer protein sec14p
View Download 0.231 N/A N/A a.24.17 Group V grass pollen allergen
View Download 0.230 N/A N/A d.230.3 Amyloid beta a4 protein copper binding domain (domain 2)
View Download 0.225 N/A N/A a.6.1 Putative DNA-binding domain
View Download 0.225 N/A N/A a.60.9 lambda integrase-like, N-terminal domain
View Download 0.224 N/A N/A a.77.1 DEATH domain
View Download 0.222 N/A N/A d.15.7 Immunoglobulin-binding domains
View Download 0.222 N/A N/A a.39.1 EF-hand
View Download 0.217 N/A N/A a.77.1 DEATH domain
View Download 0.213 N/A N/A a.2.7 tRNA-binding arm
View Download 0.211 N/A N/A a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.210 N/A N/A a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.206 N/A N/A a.77.1 DEATH domain
View Download 0.203 N/A N/A a.5.1 DNA helicase RuvA subunit, C-terminal domain
View Download 0.202 N/A N/A a.43.1 Met repressor-like
View Download 0.200 N/A N/A a.4.3 ARID-like

Predicted Domain #4
Region A:
Residues: [395-528]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DEKKFYYLEL FEIMKISTLM FFQLTLLKID KDSLELQILR NKLDSKLDKV IGTFLEGSLC  60
   61 FPLFIYGVCI QVEDMEKKID LEAKFDDILK RYKCYNFQNA RLLIRKIWQN EADGISEHDL 120
  121 VHMIDELDYN INFA

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle