YRC Public Data Repository - Protein Structure Prediction

Protein:	RPN5
Organism:	Saccharomyces cerevisiae
Length:	445 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RPN5.

Description	E-value	Query Range	Subject Range
gi\|73965259 - gi\|73965259\|ref\|XP_537584.2\| PREDICTED: similar to 26S proteasome non-ATPase regulatory subunit 12 (...	368.0	[0..7]	[443..14]
PSD12_PONAB - 26S proteasome non-ATPase regulatory subunit 12 OS=Pongo abelii GN=PSMD12 PE=2 SV=3 PSD12_PONPY - 26S proteasome non-ATPase regulatory subunit 12 - Pongo pygmaeus (Orangutan)	367.0	[0..7]	[443..14]
gi\|123985956, gi... - gi\|168275714\|dbj\|BAG10577.1\| 26S proteasome non-ATPase regulatory subunit 12 [synthetic construct], ... gi\|114670121 - gi\|114670121\|ref\|XP_511639.2\| PREDICTED: proteasome 26S non-ATPase subunit 12 [Pan troglodytes] gi\|109117036 - gi\|109117036\|ref\|XP_001116817.1\| PREDICTED: proteasome 26S non-ATPase subunit 12 isoform 2 [Macaca m... PSMD12 - proteasome (prosome, macropain) 26S subunit, non-ATPase, 12	367.0	[0..7]	[443..14]
PSD12_BOVIN - 26S proteasome non-ATPase regulatory subunit 12 OS=Bos taurus GN=PSMD12 PE=2 SV=3	365.0	[0..7]	[443..14]
gi\|12857304 - gi\|12857304\|dbj\|BAB30969.1\| unnamed protein product [Mus musculus]	365.0	[0..7]	[443..14]
gi\|54400716, gi\|... - gi\|54400716\|ref\|NP_001005875.1\| proteasome 26S non-ATPase subunit 12 [Rattus norvegicus], gi\|5373354...	365.0	[0..7]	[443..14]
gi\|53136554, gi\|... - gi\|71897101\|ref\|NP_001025877.1\| proteasome 26S non-ATPase subunit 12 [Gallus gallus], gi\|53136554\|em...	363.0	[0..7]	[443..14]

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Predicted Domain #1

Region A:
Residues: [1-101]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRDAPIKAD KDYSQILKEE FPKIDSLAQN DCNSALDQLL VLEKKTRQAS DLASSKEVLA  60
   61 KIVDLLASRN KWDDLNEQLT LLSKKHGQLK LSIQYMIQKV M

[Run NCBI BLAST on this sequence.]

Detection Method:	ab initio
Confidence:	13.64
Match:
Description:	No description for 1hz4A was found.

Predicted Domain #2

Region A:
Residues: [102-222]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EYLKSSKSLD LNTRISVIET IRVVTENKIF VEVERARVTK DLVEIKKEEG KIDEAADILC  60
   61 ELQVETYGSM EMSEKIQFIL EQMELSILKG DYSQATVLSR KILKKTFKNP KYESLKLEYY 120
  121 N

[Run NCBI BLAST on this sequence.]

Detection Method:	ab initio
Confidence:	13.64
Match:
Description:	No description for 1hz4A was found.

Predicted Domain #3

Region A:
Residues: [223-370]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LLVKISLHKR EYLEVAQYLQ EIYQTDAIKS DEAKWKPVLS HIVYFLVLSP YGNLQNDLIH  60
   61 KIQNDNNLKK LESQESLVKL FTTNELMRWP IVQKTYEPVL NEDDLAFGGE ANKHHWEDLQ 120
  121 KRVIEHNLRV ISEYYSRITL LRLNELLD

[Run NCBI BLAST on this sequence.]

Detection Method:	ab initio
Confidence:	13.64
Match:
Description:	No description for 1hz4A was found.

Predicted Domain #4

Region A:
Residues: [371-445]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LTESQTETYI SDLVNQGIIY AKVNRPAKIV NFEKPKNSSQ LLNEWSHNVD ELLEHIETIG  60
   61 HLITKEEIMH GLQAK

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.914	N/A	N/A	d.58.4	Dimeric alpha+beta barrel
View	Download	0.856	N/A	N/A	d.58.4	Dimeric alpha+beta barrel
View	Download	0.847	N/A	N/A	d.52.1	Alpha-lytic protease prodomain
View	Download	0.839	N/A	N/A	d.58.18	Regulatory domain in the aminoacid metabolism
View	Download	0.828	N/A	N/A	d.58.11	EF-G/eEF-2 domains III and V
View	Download	0.778	N/A	N/A	d.58.17	Metal-binding domain
View	Download	0.735	N/A	N/A	d.52.1	Alpha-lytic protease prodomain
View	Download	0.730	N/A	N/A	d.58.10	Acylphosphatase-like
View	Download	0.708	N/A	N/A	d.52.4	YhbC-like, N-terminal domain

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits