YRC Public Data Repository - Protein Structure Prediction

Protein:	PPH21
Organism:	Saccharomyces cerevisiae
Length:	369 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PPH21.

Description	E-value	Query Range	Subject Range
PP2A1_YEAST - Serine/threonine-protein phosphatase PP2A-1 catalytic subunit OS=Saccharomyces cerevisiae (strain AT... gi\|190405138 - gi\|190405138\|gb\|EDV08405.1\| serine/threonine-protein phosphatase PP2A-1 catalytic subunit [Saccharom... gi\|151941867 - gi\|151941867\|gb\|EDN60223.1\| protein phosphatase type 2A [Saccharomyces cerevisiae YJM789] PPH21 - Catalytic subunit of protein phosphatase 2A (PP2A), functionally redundant with Pph22p; methylated a...	0.0	[1..369]	[1..369]
PP2AA_CHICK - Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform OS=Gallus gallus GN=PPP2CA P...	0.0	[68..369]	[8..309]
gi\|67970493, gi\|... - gi\|67970495\|dbj\|BAE01590.1\| unnamed protein product [Macaca fascicularis], gi\|67970493\|dbj\|BAE01589.... PPP2CA - protein phosphatase 2, catalytic subunit, alpha isozyme PP2AA_PIG - Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform OS=Sus scrofa GN=PPP2CA PE=2... PP2AA_RABIT - Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform OS=Oryctolagus cuniculus GN=... tr\|M3X381\|M3X381... - Serine/threonine-protein phosphatase OS=Felis catus GN=PPP2CA PE=3 SV=1 gi\|109078612 - gi\|109078612\|ref\|XP_001108011.1\| PREDICTED: similar to protein phosphatase 2, catalytic subunit, alp... gi\|89267 - pir\|\|A27430 phosphoprotein phosphatase (EC 3.1.3.16) 2-alpha catalytic chain - pig gi\|168277916 - gi\|168277916\|dbj\|BAG10936.1\| serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform... PP2AA_BOVIN - Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform OS=Bos taurus GN=PPP2CA PE=1...	0.0	[63..369]	[3..309]
PP2AB_RABIT - Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform OS=Oryctolagus cuniculus GN=P...	0.0	[63..369]	[3..309]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[63..369]	[3..309]
gi\|119390121 - gi\|119390121\|pdb\|2IE3\|C Chain C, Structure Of The Protein Phosphatase 2a Core Enzyme Bound To Tumor-... PP2AA_RAT - Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform OS=Rattus norvegicus GN=Ppp2... PP2AA_MOUSE - Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform OS=Mus musculus GN=Ppp2ca PE... gi\|56819 - gi\|56819\|emb\|CAA34166.1\| unnamed protein product [Rattus rattus]	0.0	[63..369]	[3..309]
gi\|50978726, gi\|... - gi\|50978726\|ref\|NP_001003063.1\| type 2A protein phosphatase catalytic subunit [Canis lupus familiari...	0.0	[63..369]	[3..309]

Back

Predicted Domain #1

Region A:
Residues: [1-369]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDTDLDVPMQ DAVTEQLTPT VSEDMDLNNN SSDNNAEEFS VDDLKPGSSG IADHKSSKPL  60
   61 ELNNTNINQL DQWIEHLSKC EPLSEDDVAR LCKMAVDVLQ FEENVKPINV PVTICGDVHG 120
  121 QFHDLLELFK IGGPCPDTNY LFMGDYVDRG YYSVETVSYL VAMKVRYPHR ITILRGNHES 180
  181 RQITQVYGFY DECLRKYGSA NVWKMFTDLF DYFPITALVD NKIFCLHGGL SPMIETIDQV 240
  241 RELNRIQEVP HEGPMCDLLW SDPDDRGGWG ISPRGAGFTF GQDVSEQFNH TNDLSLIARA 300
  301 HQLVMEGYAW SHQQNVVTIF SAPNYCYRCG NQAAIMEVDE NHNRQFLQYD PSVRPGEPSV 360
  361 SRKTPDYFL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	920.0
Match:	1it6A_
Description:	Protein phosphatase-1 (PP-1)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
phosphoprotein phosphatase activity	11.6417995308386	bayes_pls_golite062009
protein serine/threonine phosphatase activity	10.6440947462013	bayes_pls_golite062009
phosphatase activity	10.5525832502704	bayes_pls_golite062009
phosphoric ester hydrolase activity	10.3702645338723	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	9.02791306892273	bayes_pls_golite062009
calcium-dependent protein serine/threonine phosphatase activity	6.04386346716682	bayes_pls_golite062009
myosin phosphatase activity	5.31703100176823	bayes_pls_golite062009
hydrolase activity	3.13006743434485	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	1.68552051869632	bayes_pls_golite062009
kinase activity	1.67788383575784	bayes_pls_golite062009
structural molecule activity	1.5850868178597	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.57807175808088	bayes_pls_golite062009
protein kinase activity	1.4514460578232	bayes_pls_golite062009
binding	1.44538582463569	bayes_pls_golite062009
catalytic activity	1.39852585255405	bayes_pls_golite062009
transferase activity	1.3407391509244	bayes_pls_golite062009
protein binding	1.33435965029646	bayes_pls_golite062009
transporter activity	1.24767072239634	bayes_pls_golite062009
molecular transducer activity	1.08090214431427	bayes_pls_golite062009
signal transducer activity	1.08090214431427	bayes_pls_golite062009
calmodulin binding	0.77173071932406	bayes_pls_golite062009
protein serine/threonine kinase activity	0.66803085638835	bayes_pls_golite062009
substrate-specific transporter activity	0.528189469950839	bayes_pls_golite062009
structural constituent of muscle	0.126411744957937	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: