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View Structure Prediction Details

Protein: YFH1
Organism: Saccharomyces cerevisiae
Length: 174 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YFH1.

Description E-value Query
Range		 Subject
Range
gi|151941884 - gi|151941884|gb|EDN60240.1| conserved protein [Saccharomyces cerevisiae YJM789]
FRDA_YEAST - Frataxin homolog, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YFH1 PE=...
gi|207347031 - gi|207347031|gb|EDZ73347.1| YDL120Wp-like protein [Saccharomyces cerevisiae AWRI1631]
YFH1 - Mitochondrial matrix iron chaperone; oxidizes and stores iron; interacts with Isu1p to promote Fe-S ...
gi|190405122 - gi|190405122|gb|EDV08389.1| hypothetical protein SCRG_00614 [Saccharomyces cerevisiae RM11-1a]
 3.0E-76 [1..174] [1..174]
fh-PA - The gene frataxin homolog is referred to in FlyBase by the symbol Dmel\fh (CG8971, FBgn0030092). It ...
gi|220949572 - gi|220949572|gb|ACL87329.1| fh-PA [synthetic construct]
 1.0E-36 [53..174] [55..179]
gi|11559522 - gi|11559522|gb|AAG37996.1|AF209098_1 frataxin-like protein [Drosophila subobscura]
 1.0E-36 [53..174] [50..174]
FRDA_MOUSE - Frataxin, mitochondrial OS=Mus musculus GN=Fxn PE=1 SV=1
 1.0E-36 [73..171] [92..192]
CYAY_DICCH - Protein CyaY OS=Dickeya chrysanthemi GN=cyaY PE=3 SV=1
 2.0E-35 [71..168] [4..97]
gi|11513844 - gi|11513844|pdb|1EKG|A Chain A, Mature Human Frataxin
 3.0E-35 [68..170] [7..111]
frh-1 - status:Confirmed UniProt:Q9TY03 protein_id:AAK31530.1
 1.0E-34 [48..171] [7..126]
CYAY_YERIN - Protein CyaY OS=Yersinia intermedia GN=cyaY PE=3 SV=1
 6.0E-34 [69..167] [3..97]
SPCC1183.03c - frataxin homolog
FRDA_SCHPO - Frataxin homolog, mitochondrial OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPCC1183.0...
 1.0E-33 [72..172] [46..148]

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Predicted Domain #1
Region A:
Residues: [1-174] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIKRSLASLV RVSSVMGRRY MIAAAGGERA RFCPAVTNKK NHTVNTFQKR FVESSTDGQV  60
   61 VPQEVLNLPL EKYHEEADDY LDHLLDSLEE LSEAHPDCIP DVELSHGVMT LEIPAFGTYV 120
  121 INKQPPNKQI WLASPLSGPN RFDLLNGEWV SLRNGTKLTD ILTEEVEKAI SKSQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 188.218487
Match: 1ekgA_
Description: C-terminal domain of frataxin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
iron chaperone activity 4.16905358201916 bayes_pls_golite062009
ferric iron binding 3.17697632477325 bayes_pls_golite062009
iron ion binding 2.78584553912929 bayes_pls_golite062009
2 iron, 2 sulfur cluster binding 2.25545886640675 bayes_pls_golite062009
transition metal ion binding 1.85229574432416 bayes_pls_golite062009
metallochaperone activity 1.67572555512957 bayes_pls_golite062009
ferrous iron binding 1.61332056179381 bayes_pls_golite062009
binding 1.55331726001774 bayes_pls_golite062009
cation binding 1.42164579673909 bayes_pls_golite062009
metal ion binding 1.42164579673909 bayes_pls_golite062009
ion binding 1.4150396069236 bayes_pls_golite062009
oxidoreductase activity 1.07282105096776 bayes_pls_golite062009
metal cluster binding 0.602901470550009 bayes_pls_golite062009
iron-sulfur cluster binding 0.602901470550009 bayes_pls_golite062009
protein binding 0.356112453590986 bayes_pls_golite062009
oxidoreductase activity, oxidizing metal ions, oxygen as acceptor 0.310374472796773 bayes_pls_golite062009
ferroxidase activity 0.310374472796773 bayes_pls_golite062009
catalytic activity 0.276917867171685 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle