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View Structure Prediction Details

Protein: UBX3
Organism: Saccharomyces cerevisiae
Length: 455 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for UBX3.

Description E-value Query
Range
Subject
Range
UBX3 - UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p, green fluorescent...
gi|207346999 - gi|207346999|gb|EDZ73321.1| YDL091Cp-like protein [Saccharomyces cerevisiae AWRI1631]
UBX3_YEAST - UBX domain-containing protein 3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=UBX3 PE=...
gi|151941910 - gi|151941910|gb|EDN60266.1| ubiquitin regulatory X [Saccharomyces cerevisiae YJM789]
0.0 [1..455] [1..455]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
7.0E-69 [124..451] [130..464]
PUX10_ARATH - Plant UBX domain-containing protein 10 OS=Arabidopsis thaliana GN=PUX10 PE=2 SV=1
9.0E-67 [124..451] [144..478]
gi|215678662, gi... - gi|37536146|ref|NP_922375.1| unknown protein [Oryza sativa (japonica cultivar-group)], gi|31433109|g...
9.0E-61 [128..451] [133..463]
UCP10_SCHPO - UBX domain-containing protein 10 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=ucp10 PE=...
ucp10 - UBA /UAS domain protein Ucp10
2.0E-58 [141..455] [101..427]
gi|168278371, gi... - gi|168278371|dbj|BAG11065.1| FAS-associated factor 1 [synthetic construct], gi|123999215|gb|ABM87187...
FAF1 - Fas (TNFRSF6) associated factor 1
1.0E-57 [135..452] [325..648]
Faf-PA, FBpp0309814 - The gene Fas-associated factor is referred to in FlyBase by the symbol Dmel\Faf (CG10372, FBgn002560...
gi|220955346, gi... - gi|220955346|gb|ACL90216.1| Faf-PA [synthetic construct], gi|220945460|gb|ACL85273.1| Faf-PA [synthe...
8.0E-57 [129..453] [129..462]

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Predicted Domain #1
Region A:
Residues: [1-124]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDIFRHTFGN NDDSFIRIPG AFREEPPADL NGRTEDQNSN TNEPTQSRDG RLKSILHFLF  60
   61 QAPLIVLYYL LNFIVRSSRL LKPLLRLHGF YQRKHNRLLD HSSQLHRLLE NLENEAQAVT 120
  121 CSEG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.815 a.7.8 GAT domain
View Download 0.730 a.23.1 HSC20 (HSCB), C-terminal oligomerisation domain
View Download 0.714 a.85.1 Hemocyanin, N-terminal domain
View Download 0.556 a.118.11 Cytochrome c oxidase subunit E
View Download 0.451 d.195.1 YopH tyrosine phosphatase N-terminal domain

Predicted Domain #2
Region A:
Residues: [125-288]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NGNNDDGSNT DSTSNNESSG VQFSFGSLYN PENGTFSKSI MQNSYTELLD ACSEQVKFGV  60
   61 IYLHDPLLDN HMDYVNKILC SEAFVNMIRK YQVLLWYGDV TTSEGLQVSN ALKIRQYPLL 120
  121 GIISLKAEKK IELIARVEGS ISNYKAQDLE AIFSKNYSRL IQLR

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.664 0.646 cytoplasm c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.627 0.109 cytoplasm c.1.10 Aldolase
View Download 0.767 0.066 cytoplasm c.1.2 Ribulose-phoshate binding barrel
View Download 0.553 0.016 cytoplasm c.23.4 Succinyl-CoA synthetase domains
View Download 0.652 0.000 cytoplasm c.23.6 Cobalamin (vitamin B12)-binding domain
View Download 0.525 N/A N/A c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.517 N/A N/A c.3.1 FAD/NAD(P)-binding domain
View Download 0.508 N/A N/A c.95.1 Thiolase-like
View Download 0.501 N/A N/A c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.471 N/A N/A c.25.1 Ferredoxin reductase-like, C-terminal NADP-linked domain
View Download 0.469 N/A N/A c.23.1 CheY-like
View Download 0.467 N/A N/A c.51.3 B12-dependend dehydatases associated subunit
View Download 0.451 N/A N/A c.46.1 Rhodanese/Cell cycle control phosphatase
View Download 0.438 N/A N/A c.1.17 Quinolinic acid phosphoribosyltransferase (Nicotinate-nucleotide pyrophosphorylase, NadC), C-terminal domain
View Download 0.436 N/A N/A c.84.1 Phosphoglucomutase, first 3 domains
View Download 0.416 N/A N/A d.110.2 GAF domain-like
View Download 0.410 N/A N/A c.1.12 Phosphoenolpyruvate/pyruvate domain
View Download 0.407 N/A N/A c.59.1 MurD-like peptide ligases, peptide-binding domain
View Download 0.403 N/A N/A c.53.1 Resolvase-like
View Download 0.401 N/A N/A d.87.1 FAD/NAD-linked reductases, dimerisation (C-terminal) domain
View Download 0.401 N/A N/A c.52.1 Restriction endonuclease-like
View Download 0.393 N/A N/A c.61.1 PRTase-like
View Download 0.387 N/A N/A c.72.1 Ribokinase-like
View Download 0.385 N/A N/A d.211.1 Ankyrin repeat
View Download 0.382 N/A N/A c.26.2 Adenine nucleotide alpha hydrolases-like
View Download 0.358 N/A N/A c.10.1 RNI-like
View Download 0.348 N/A N/A c.61.1 PRTase-like
View Download 0.347 N/A N/A c.36.1 Thiamin diphosphate-binding fold (THDP-binding)
View Download 0.333 N/A N/A c.84.1 Phosphoglucomutase, first 3 domains
View Download 0.328 N/A N/A b.60.1 Lipocalins
View Download 0.318 N/A N/A c.1.8 (Trans)glycosidases
View Download 0.317 N/A N/A c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.310 N/A N/A a.1.1 Globin-like
View Download 0.303 N/A N/A c.58.1 Aminoacid dehydrogenase-like, N-terminal domain
View Download 0.302 N/A N/A c.93.1 Periplasmic binding protein-like I
View Download 0.291 N/A N/A c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.283 N/A N/A c.1.10 Aldolase
View Download 0.281 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.280 N/A N/A c.1.11 Enolase C-terminal domain-like
View Download 0.267 N/A N/A c.23.12 Formate/glycerate dehydrogenase catalytic domain-like
View Download 0.267 N/A N/A c.26.3 UDP-glucose/GDP-mannose dehydrogenase C-terminal domain
View Download 0.265 N/A N/A b.34.9 Tudor/PWWP/MBT
View Download 0.264 N/A N/A c.23.12 Formate/glycerate dehydrogenase catalytic domain-like
View Download 0.263 N/A N/A c.51.2 TolB, N-terminal domain
View Download 0.262 N/A N/A c.47.1 Thioredoxin-like
View Download 0.251 N/A N/A c.66.1 S-adenosyl-L-methionine-dependent methyltransferases
View Download 0.247 N/A N/A c.1.8 (Trans)glycosidases
View Download 0.240 N/A N/A a.1.1 Globin-like
View Download 0.238 N/A N/A c.52.1 Restriction endonuclease-like
View Download 0.234 N/A N/A c.53.1 Resolvase-like
View Download 0.233 N/A N/A c.3.1 FAD/NAD(P)-binding domain
View Download 0.230 N/A N/A c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.229 N/A N/A c.52.1 Restriction endonuclease-like
View Download 0.228 N/A N/A c.49.1 Pyruvate kinase, C-terminal domain
View Download 0.224 N/A N/A d.153.1 N-terminal nucleophile aminohydrolases (Ntn hydrolases)
View Download 0.223 N/A N/A a.74.1 Cyclin-like
View Download 0.222 N/A N/A c.23.5 Flavoproteins
View Download 0.220 N/A N/A c.1.14 RuBisCo, C-terminal domain
View Download 0.219 N/A N/A a.79.1 Antitermination factor NusB
View Download 0.217 N/A N/A d.75.2 DNA repair protein MutS, domain I
View Download 0.216 N/A N/A c.6.3 PHP domain
View Download 0.213 N/A N/A c.1.26 Betaine-homocysteine S-methyltransferase
View Download 0.213 N/A N/A c.111.1 Activating enzymes of the ubiquitin-like proteins
View Download 0.210 N/A N/A c.23.13 Type II 3-dehydroquinate dehydratase
View Download 0.209 N/A N/A c.62.1 vWA-like
View Download 0.205 N/A N/A c.23.13 Type II 3-dehydroquinate dehydratase

Predicted functions:

Term Confidence Notes
antioxidant activity 1.01389552298489 bayes_pls_golite062009
peroxidase activity 0.753319016725885 bayes_pls_golite062009
oxidoreductase activity, acting on peroxide as acceptor 0.753319016725885 bayes_pls_golite062009
protein disulfide isomerase activity 0.162300810242639 bayes_pls_golite062009
intramolecular oxidoreductase activity, transposing S-S bonds 0.162300810242639 bayes_pls_golite062009
catalytic activity 0.129588295266429 bayes_pls_golite062009
binding 0.064243103392096 bayes_pls_golite062009
peroxiredoxin activity 0.0343881005856616 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [289-356]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QQRQNIEMQR LIRQQQDSRY QDSLRRDQQR ESERLEQTQR EQMEREHQRI ENQWLLWRKS  60
   61 QLKPEPSS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.705 a.16.1 S15/NS1 RNA-binding domain
View Download 0.630 a.7.3 Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain
View Download 0.554 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.669 a.2.7 tRNA-binding arm
View Download 0.559 i.1.1 Ribosome and ribosomal fragments
View Download 0.548 a.2.8 Eukaryotic DNA topoisomerase I, dispensable insert domain
View Download 0.543 a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.527 a.16.1 S15/NS1 RNA-binding domain
View Download 0.519 a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.512 a.16.1 S15/NS1 RNA-binding domain
View Download 0.503 a.2.10 Epsilon subunit of F1F0-ATP synthase C-terminal domain
View Download 0.486 a.4.5 "Winged helix" DNA-binding domain
View Download 0.473 a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.447 a.23.5 Hemolysin expression modulating protein HHA
View Download 0.447 a.2.10 Epsilon subunit of F1F0-ATP synthase C-terminal domain
View Download 0.447 a.16.1 S15/NS1 RNA-binding domain
View Download 0.446 a.157.1 Skp1 dimerisation domain-like
View Download 0.443 f.17.1 F1F0 ATP synthase subunit C
View Download 0.432 a.4.5 "Winged helix" DNA-binding domain
View Download 0.417 a.60.2 RuvA domain 2-like
View Download 0.417 a.2.8 Eukaryotic DNA topoisomerase I, dispensable insert domain
View Download 0.417 a.37.1 A DNA-binding domain in eukaryotic transcription factors
View Download 0.413 a.30.1 ROP protein
View Download 0.401 a.4.1 Homeodomain-like
View Download 0.389 d.54.1 Enolase N-terminal domain-like
View Download 0.388 f.13.1 Family A G protein-coupled receptor-like
View Download 0.387 a.2.7 tRNA-binding arm
View Download 0.380 a.2.7 tRNA-binding arm
View Download 0.375 a.4.5 "Winged helix" DNA-binding domain
View Download 0.366 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.349 a.4.12 TrpR-like
View Download 0.348 a.2.8 Eukaryotic DNA topoisomerase I, dispensable insert domain
View Download 0.342 a.60.12 DNA polymerase beta-like, second domain
View Download 0.339 f.17.1 F1F0 ATP synthase subunit C
View Download 0.333 f.17.1 F1F0 ATP synthase subunit C
View Download 0.327 a.101.1 Uteroglobin-like
View Download 0.326 a.2.8 Eukaryotic DNA topoisomerase I, dispensable insert domain
View Download 0.325 f.17.1 F1F0 ATP synthase subunit C
View Download 0.325 a.30.1 ROP protein
View Download 0.321 a.7.6 Ribosomal protein S20
View Download 0.317 a.16.1 S15/NS1 RNA-binding domain
View Download 0.315 a.71.2 Helical domain of Sec23/24
View Download 0.313 a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.313 a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.311 a.90.1 Transcription factor STAT-4 N-domain
View Download 0.309 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.306 a.17.1 p8-MTCP1
View Download 0.294 a.2.8 Eukaryotic DNA topoisomerase I, dispensable insert domain
View Download 0.293 f.13.1 Family A G protein-coupled receptor-like
View Download 0.293 a.2.2 Ribosomal protein L29 (L29p)
View Download 0.289 a.30.2 Homodimeric domain of signal transducing histidine kinase
View Download 0.275 a.77.1 DEATH domain
View Download 0.275 f.13.1 Family A G protein-coupled receptor-like
View Download 0.272 f.13.1 Family A G protein-coupled receptor-like
View Download 0.272 a.24.4 Hemerythrin
View Download 0.272 a.2.8 Eukaryotic DNA topoisomerase I, dispensable insert domain
View Download 0.272 a.24.17 Group V grass pollen allergen
View Download 0.269 f.13.1 Family A G protein-coupled receptor-like
View Download 0.269 a.46.1 Methionine synthase domain
View Download 0.267 a.2.8 Eukaryotic DNA topoisomerase I, dispensable insert domain
View Download 0.264 a.2.7 tRNA-binding arm
View Download 0.264 c.47.1 Thioredoxin-like
View Download 0.261 a.2.7 tRNA-binding arm
View Download 0.261 a.30.1 ROP protein
View Download 0.260 a.77.1 DEATH domain
View Download 0.260 a.108.1 Ribosomal protein L7/12, oligomerisation (N-terminal) domain
View Download 0.256 a.30.2 Homodimeric domain of signal transducing histidine kinase
View Download 0.255 a.108.1 Ribosomal protein L7/12, oligomerisation (N-terminal) domain
View Download 0.254 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.253 a.2.9 C-terminal UvrC-binding domain of UvrB
View Download 0.253 a.16.1 S15/NS1 RNA-binding domain
View Download 0.253 f.34.1 Mechanosensitive channel protein MscS (YggB), transmembrane region
View Download 0.252 a.16.1 S15/NS1 RNA-binding domain
View Download 0.249 a.4.1 Homeodomain-like
View Download 0.249 d.68.7 R3H domain
View Download 0.249 f.13.1 Family A G protein-coupled receptor-like
View Download 0.247 a.51.1 Cytochrome c oxidase subunit h
View Download 0.244 a.2.10 Epsilon subunit of F1F0-ATP synthase C-terminal domain
View Download 0.242 f.17.1 F1F0 ATP synthase subunit C
View Download 0.238 a.16.1 S15/NS1 RNA-binding domain
View Download 0.237 a.30.1 ROP protein
View Download 0.235 a.2.9 C-terminal UvrC-binding domain of UvrB
View Download 0.235 a.2.2 Ribosomal protein L29 (L29p)
View Download 0.233 a.76.1 Iron-dependent represor protein, dimerization domain
View Download 0.232 a.2.10 Epsilon subunit of F1F0-ATP synthase C-terminal domain
View Download 0.231 a.2.3 Chaperone J-domain
View Download 0.229 a.4.8 Ribosomal protein S18
View Download 0.228 a.2.7 tRNA-binding arm
View Download 0.227 a.2.7 tRNA-binding arm
View Download 0.223 a.7.6 Ribosomal protein S20
View Download 0.220 a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.219 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.219 a.65.1 Annexin
View Download 0.219 a.64.1 Saposin
View Download 0.216 d.49.1 Signal recognition particle alu RNA binding heterodimer, SRP9/14
View Download 0.212 a.2.6 Effector domain of the protein kinase pkn/prk1
View Download 0.208 a.35.1 lambda repressor-like DNA-binding domains
View Download 0.205 f.13.1 Family A G protein-coupled receptor-like
View Download 0.204 a.7.2 Enzyme IIa from lactose specific PTS, IIa-lac
View Download 0.202 a.8.1 Bacterial immunoglobulin/albumin-binding domains

Predicted Domain #4
Region A:
Residues: [357-455]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DKDASKVAIR LENGQRLVRK FDASLPTEEI YAFVELQLHD MLNSENDTLP VYQPANYQHQ  60
   61 YSFKLITPVP RRELDLSTKI SDVSGIYPSG NIVMERLDE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.09691
Match: 1h8cA_
Description: Fas-assosiated factor 1, Faf1
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle