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View Structure Prediction Details

Protein: LHP1
Organism: Saccharomyces cerevisiae
Length: 275 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LHP1.

Description E-value Query
Range		 Subject
Range
PABP1_MOUSE - Polyadenylate-binding protein 1 OS=Mus musculus GN=Pabpc1 PE=1 SV=2
 9.0E-55 [17..247] [94..312]
PABP1_BOVIN - Polyadenylate-binding protein 1 OS=Bos taurus GN=PABPC1 PE=2 SV=1
gi|109087089 - gi|109087089|ref|XP_001098239.1| PREDICTED: poly(A) binding protein, cytoplasmic 1 isoform 2 [Macaca...
gi|123993665, gi... - gi|168278070|dbj|BAG11013.1| polyadenylate-binding protein 1 [synthetic construct], gi|123999981|gb|...
gi|194036975 - gi|194036975|ref|XP_001927782.1| PREDICTED: similar to Polyadenylate-binding protein 1 (Poly(A)-bind...
PABPC1 - poly(A) binding protein, cytoplasmic 1
gi|73974130, gi|... - gi|73974178|ref|XP_857695.1| PREDICTED: similar to Polyadenylate-binding protein 1 (Poly(A)-binding ...
 1.0E-54 [17..247] [94..312]
PABP1_RAT - Polyadenylate-binding protein 1 OS=Rattus norvegicus GN=Pabpc1 PE=1 SV=1
 2.0E-54 [17..247] [94..312]
gi|13540314 - gi|13540314|gb|AAK29408.1|AF338225_1 embryonic poly(A) binding protein [Xenopus laevis]
 8.0E-53 [17..247] [94..312]
gi|19526272 - gi|19526272|gb|AAL89666.1|AF411956_7 polyA-binding protein [Takifugu rubripes]
 2.0E-51 [17..269] [94..329]

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Predicted Domain #1
Region A:
Residues: [1-107] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEKPQQEEQ EKPQSRRNSF AVIEFTPEVL DRCLKQVEFY FSEFNFPYDR FLRTTAEKND  60
   61 GWVPISTIAT FNRMKKYRPV DKVIEALRSS EILEVSADGE NVKRRVP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 27.522879
Match: 1cvjA_
Description: Poly(A)-binding protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 4.46119712758726 bayes_pls_golite062009
nucleic acid binding 3.81920018903278 bayes_pls_golite062009
mRNA binding 3.05425904007847 bayes_pls_golite062009
binding 3.05116833253954 bayes_pls_golite062009
2.36751082234253 bayes_pls_golite062009
transcription regulator activity 1.07788694919471 bayes_pls_golite062009
DNA binding 0.978604858165557 bayes_pls_golite062009
single-stranded RNA binding 0.852368751354665 bayes_pls_golite062009
ligase activity 0.633198446266208 bayes_pls_golite062009
poly-pyrimidine tract binding 0.56829350502235 bayes_pls_golite062009
protein binding 0.42571879933058 bayes_pls_golite062009
transcription factor activity 0.234742017105535 bayes_pls_golite062009
snoRNA binding 0.13655584674226 bayes_pls_golite062009
structural molecule activity 0.0823205596024605 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [108-275] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LDLTAARNAR IEQNQRTLAV MNFPHEDVEA SQIPELQENL EAFFKKLGEI NQVRLRRDHR  60
   61 NKKFNGTVLV EFKTIPECEA FLKSYSNDDE SNEILSYEGK KLSVLTKKQF DLQREASKSK 120
  121 NFSGRSRSFN GHKKKNLPKF PKNKKKNGKE ESKEDSSAIA DDDEEHKE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 27.522879
Match: 1cvjA_
Description: Poly(A)-binding protein
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle