YRC Public Data Repository - Protein Structure Prediction

Protein:	GRX6
Organism:	Saccharomyces cerevisiae
Length:	231 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GRX6.

Description	E-value	Query Range	Subject Range
GLRX6_YEAST - Monothiol glutaredoxin-6 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GRX6 PE=1 SV=1 GRX6 - Cis-golgi localized monothiol glutaredoxin that binds an iron-sulfur cluster; more similar in activi...	6.0E-46	[1..231]	[1..231]
gi\|153213977, gi... - gi\|153213977\|ref\|ZP_01949170.1\| peroxiredoxin family protein/glutaredoxin [Vibrio cholerae 1587], gi... gi\|121630083, gi... - gi\|121727592\|ref\|ZP_01680700.1\| peroxiredoxin family protein/glutaredoxin [Vibrio cholerae V52], gi\|... gi\|254846881, gi... - gi\|254851176\|ref\|ZP_05240526.1\| peroxiredoxin family protein/glutaredoxin [Vibrio cholerae MO10], gi... gi\|229345953, gi... - gi\|229516890\|ref\|ZP_04406336.1\| peroxiredoxin family protein/glutaredoxin [Vibrio cholerae RC9], gi\|... gi\|153224207, gi... - gi\|153224207\|ref\|ZP_01954293.1\| peroxiredoxin family protein/glutaredoxin [Vibrio cholerae MAK 757],... gi\|229369472, gi... - gi\|229606817\|ref\|YP_002877465.1\| peroxiredoxin family protein/glutaredoxin [Vibrio cholerae MJ-1236]... gi\|126510002, gi... - gi\|153819461\|ref\|ZP_01972128.1\| peroxiredoxin family protein/glutaredoxin [Vibrio cholerae NCTC 8457... gi\|194537404, gi... - gi\|254225383\|ref\|ZP_04918994.1\| peroxiredoxin family protein/glutaredoxin [Vibrio cholerae V51], gi\|... gi\|229509765, gi... - gi\|229509765\|ref\|ZP_04399246.1\| peroxiredoxin family protein/glutaredoxin [Vibrio cholerae B33], gi\|... gi\|254285832, gi... - gi\|254285832\|ref\|ZP_04960794.1\| peroxiredoxin family protein/glutaredoxin [Vibrio cholerae AM-19226]... gi\|194536460, gi... - gi\|254222313\|ref\|ZP_04916185.1\| peroxiredoxin family protein/glutaredoxin [Vibrio cholerae RC385], g... gi\|153825079, gi... - gi\|153825079\|ref\|ZP_01977746.1\| peroxiredoxin family protein/glutaredoxin [Vibrio cholerae MZO-2], g... gi\|227119075, gi... - gi\|227119075\|ref\|YP_002820971.1\| peroxiredoxin family protein/glutaredoxin [Vibrio cholerae O395], g... gi\|227082753, gi... - gi\|227082753\|ref\|YP_002811304.1\| peroxiredoxin family protein/glutaredoxin [Vibrio cholerae M66-2], ... gi\|9657228, gi\|1... - gi\|9657228\|gb\|AAF95778.1\| peroxiredoxin family protein/glutaredoxin [Vibrio cholerae O1 biovar El To... gi\|229507311, gi... - gi\|229507311\|ref\|ZP_04396816.1\| peroxiredoxin family protein/glutaredoxin [Vibrio cholerae BX 330286... gi\|11355792 - pir\|\|D82051 peroxiredoxin family protein/glutaredoxin VC2637 [imported] - Vibrio cholerae (strain N1... gi\|121587911, gi... - gi\|121587911\|ref\|ZP_01677666.1\| peroxiredoxin family protein/glutaredoxin [Vibrio cholerae 2740-80],...	6.0E-45	[18..199]	[73..241]
PRX5_HAEIN, Y572... - (P44758) Protein HI0572, Hybrid peroxiredoxin hyPrx5 OS=Haemophilus influenzae GN=HI_0572 PE=1 SV=1 gi\|260581018\|ref... - peroxiredoxin hybrid Prx5 [Haemophilus influenzae RdAW] PRX5_HAEIN - Hybrid peroxiredoxin hyPrx5 OS=Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) GN...	2.0E-44	[18..203]	[68..240]
gi\|186893469, gi... - gi\|186893469\|ref\|YP_001870581.1\| glutaredoxin family protein [Yersinia pseudotuberculosis PB1/+], gi... gi\|170026287, gi... - gi\|170026287\|ref\|YP_001722792.1\| glutaredoxin family protein [Yersinia pseudotuberculosis YPIII], gi... gi\|229695978, gi... - gi\|229839612\|ref\|ZP_04459771.1\| putative peroxiredoxin/glutaredoxin family protein [Yersinia pestis ... gi\|229691036, gi... - gi\|229841697\|ref\|ZP_04461853.1\| putative peroxiredoxin/glutaredoxin family protein [Yersinia pestis ... gi\|229896701, gi... - gi\|229896701\|ref\|ZP_04511866.1\| putative peroxiredoxin/glutaredoxin family protein [Yersinia pestis ... Q66G63\|Q66G63_YERPS - Putative peroxiredoxin/glutaredoxin family protein - Yersinia pseudotuberculosis gi\|165919612, gi... - gi\|165928382\|ref\|ZP_02224214.1\| hybrid peroxiredoxin hyPrx5 [Yersinia pestis biovar Orientalis str. ... gi\|166213757, gi... - gi\|166213757\|ref\|ZP_02239792.1\| hybrid peroxiredoxin hyPrx5 [Yersinia pestis biovar Antiqua str. B42... gi\|165991426, gi... - gi\|166009504\|ref\|ZP_02230402.1\| hybrid peroxiredoxin hyPrx5 [Yersinia pestis biovar Antiqua str. E19... gi\|167420978, gi... - gi\|167420978\|ref\|ZP_02312731.1\| hybrid peroxiredoxin hyPrx5 [Yersinia pestis biovar Orientalis str. ... gi\|167401355, gi... - gi\|167401355\|ref\|ZP_02306855.1\| hybrid peroxiredoxin hyPrx5 [Yersinia pestis biovar Antiqua str. UG0... gi\|167467890 - gi\|167467890\|ref\|ZP_02332594.1\| hybrid peroxiredoxin hyPrx5 [Yersinia pestis FV-1] gi\|167425931, gi... - gi\|167425931\|ref\|ZP_02317684.1\| hybrid peroxiredoxin hyPrx5 [Yersinia pestis biovar Mediaevalis str.... gi\|218930916, gi... - gi\|218930916\|ref\|YP_002348791.1\| putative peroxiredoxin/glutaredoxin family protein [Yersinia pestis... gi\|165915226, gi... - gi\|89102385\|ref\|ZP_01175023.1\| COG0678: Peroxiredoxin [Yersinia pestis biovar Orientalis str. IP275]... gi\|108806104, gi... - gi\|108806104\|ref\|YP_650020.1\| putative peroxiredoxin/glutaredoxin family protein [Yersinia pestis An... gi\|108810217, gi... - gi\|229904749\|ref\|ZP_04519860.1\| putative peroxiredoxin/glutaredoxin family protein [Yersinia pestis ... gi\|270488732\|ref... - glutaredoxin [Yersinia pestis KIM D27] gi\|149290529, gi... - gi\|150261121\|ref\|ZP_01917849.1\| putative peroxiredoxin/glutaredoxin family protein [Yersinia pestis ... gi\|145212471, gi... - gi\|145600775\|ref\|YP_001164851.1\| peroxiredoxin/glutaredoxin family protein [Yersinia pestis Pestoide... gi\|21957000, gi\|... - gi\|22124236\|ref\|NP_667659.1\| peroxiredoxin family protein [Yersinia pestis KIM], gi\|21957000\|gb\|AAM8... gi\|25347426 - pir\|\|AB0477 probable peroxiredoxin/glutaredoxin family protein YPO3916 [imported] - Yersinia pestis ... gi\|51587759, gi\|... - gi\|51594477\|ref\|YP_068668.1\| putative peroxiredoxin/glutaredoxin family protein [Yersinia pseudotube... gi\|45437753, gi\|... - gi\|45442886\|ref\|NP_994425.1\| putative peroxiredoxin/glutaredoxin family protein [Yersinia pestis bio... gi\|77633924, gi\|... - gi\|77633924\|ref\|ZP_00796037.1\| COG0678: Peroxiredoxin [Yersinia pestis Angola], gi\|162419256\|ref\|YP_... gi\|152960856, gi... - gi\|77630801\|ref\|ZP_00793387.1\| COG0678: Peroxiredoxin [Yersinia pseudotuberculosis IP 31758], gi\|153... gi\|294505566\|ref... - putative peroxiredoxin/glutaredoxin family protein [Yersinia pestis Z176003]	6.0E-44	[18..202]	[69..240]
gi\|11353834 - pir\|\|G81140 peroxiredoxin 2 family protein/glutaredoxin NMB0946 [imported] - Neisseria meningitidis ... gi\|121052038, gi... - gi\|7379834\|emb\|CAB84403.1\| putative redoxin [Neisseria meningitidis Z2491], gi\|218768030\|ref\|YP_0023... gi\|15676839, gi\|... - gi\|7226184\|gb\|AAF41352.1\| peroxiredoxin 2 family protein/glutaredoxin [Neisseria meningitidis MC58],... gi\|254671332 - gi\|254671332\|emb\|CBA08742.1\| putative peroxiredoxin/glutaredoxin family protein [Neisseria meningiti...	4.0E-42	[18..202]	[70..241]
gi\|17229033, gi\|... - gi\|17229033\|ref\|NP_485581.1\| peroxiredoxin 2 family protein/glutaredoxin [Nostoc sp. PCC 7120], gi\|1... gi\|25347433 - pir\|\|AG1998 peroxiredoxin 2 family protein/glutaredoxin [imported] - Nostoc sp. (strain PCC 7120)	4.0E-40	[18..202]	[69..240]
GRS16_ARATH - Bifunctional monothiol glutaredoxin-S16, chloroplastic OS=Arabidopsis thaliana GN=GRXS16 PE=1 SV=2	2.0E-35	[3..212]	[54..292]
gi\|15603212, gi\|... - gi\|15603212\|ref\|NP_246286.1\| hypothetical protein PM1347 [Pasteurella multocida subsp. multocida str...	2.0E-35	[17..203]	[67..240]
gi\|5921513 - gi\|5921513\|emb\|CAB56513.1\| putative thioredoxin-like protein [Mortierella alpina]	2.0E-34	[27..224]	[54..251]

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Predicted Domain #1

Region A:
Residues: [1-105]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIPSNKRNAR ILSITTLLLL LVFFVAQNAN FLTVEIKEET SKAFSTNMDN MAGGSSREYA  60
   61 AMPTSTTNKG SSEVDEEINE IKQKVGLQQP IASVDDSLSA IKNDK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	11.39794
Match:	1h4oA_
Description:	Peroxiredoxin 5
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
antioxidant activity	3.26520127994042	bayes_pls_golite062009
peroxidase activity	3.04028765378214	bayes_pls_golite062009
oxidoreductase activity, acting on peroxide as acceptor	3.04028765378214	bayes_pls_golite062009
peroxiredoxin activity	2.12777217096121	bayes_pls_golite062009
glutathione peroxidase activity	2.012364779649	bayes_pls_golite062009
thioredoxin peroxidase activity	1.96134566495756	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors	1.8187537496904	bayes_pls_golite062009
protein disulfide oxidoreductase activity	1.47769936616412	bayes_pls_golite062009
disulfide oxidoreductase activity	1.32811008894503	bayes_pls_golite062009
protein disulfide isomerase activity	1.04609283259723	bayes_pls_golite062009
intramolecular oxidoreductase activity, transposing S-S bonds	1.04609283259723	bayes_pls_golite062009
intramolecular oxidoreductase activity, interconverting keto- and enol-groups	0.959318279607901	bayes_pls_golite062009
binding	0.828696005067827	bayes_pls_golite062009
signal transducer activity	0.640027357599919	bayes_pls_golite062009
molecular transducer activity	0.640027357599919	bayes_pls_golite062009
hydrolase activity	0.535462970986225	bayes_pls_golite062009
selenium binding	0.422666385408905	bayes_pls_golite062009
protein binding	0.134341907247724	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH	0.11944067282418	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [106-231]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSRITKAFNV QKEYSLILDL SPIIIFSKST CSYSKGMKEL LENEYQFIPN YYIIELDKHG  60
   61 HGEELQEYIK LVTGRGTVPN LLVNGVSRGG NEEIKKLHTQ GKLLESLQVW SDGKFSVEQR 120
  121 EKPSNN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	84.40824
Match:	1kte__
Description:	Glutaredoxin (Grx, thioltransferase)
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: