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View Structure Prediction Details

Protein: RDS1
Organism: Saccharomyces cerevisiae
Length: 832 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RDS1.

Description E-value Query
Range
Subject
Range
RDS1 - Zinc cluster transcription factor involved in conferring resistance to cycloheximide
RDS1_YEAST - Regulator of drug sensitivity 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RDS1 PE=...
0.0 [1..832] [1..832]
THI1_SCHPO - Thiamine repressible genes regulatory protein thi1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 2...
thi1 - transcription factor Thi1
0.0 [3..657] [27..644]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [3..657] [27..644]
SPAC3C7.04 - transcription factor
YF54_SCHPO - Uncharacterized transcriptional regulatory protein C3C7.04 OS=Schizosaccharomyces pombe (strain 972 ...
2.0E-93 [3..598] [28..598]
gi|6901427 - gi|6901427|emb|CAB71797.1| pathway-specific nitrogen regulator [Tolypocladium inflatum]
2.0E-81 [3..517] [58..539]
gi|245224 - gi|245224|gb|AAB21394.1| NIT4=protein product involved in nitrate assimilation [Neurospora intermedi...
NIT4_NEUCR - Nitrogen assimilation transcription factor nit-4 - Neurospora crassa
4.0E-80 [6..517] [44..524]

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Predicted Domain #1
Region A:
Residues: [1-100]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDSITVKKPR LRLVCLQCKK IKRKCDKLRP ACSRCQQNSL QCEYEERTDL SANVAANDSD  60
   61 GFNSSHKLNF EQQPVLERTG LRYSLQVPEG VVNATLSIWN 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 49.38764
Match: 1hwtD_
Description: Hap1 (Cyp1); HAP1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.16002381293778 bayes_pls_golite062009
DNA binding 3.92936270801133 bayes_pls_golite062009
nucleic acid binding 3.76909067702445 bayes_pls_golite062009
binding 2.91929847152301 bayes_pls_golite062009
transcription factor activity 2.76608547022152 bayes_pls_golite062009
sequence-specific DNA binding 1.80020012839068 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.69026374220371 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.54700248976411 bayes_pls_golite062009
transcription activator activity 0.778623988601299 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [101-514]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AEDMLVIVGL VTFLDYPFAA HSLAQHDQYI RALCASLYGM ALVDFSNYAN GIPCEDTSRS  60
   61 ILGPLSFIEK AIFRRIEHSK QFRVQSAALG LLYNAFSMEE ENFSTLLPSL IAEVEDVLMQ 120
  121 KKDCEILLRC FYQNIYPFYP FMDISLFESD LTSLLLQDDN NRWKISTEVK NVRKKIETLS 180
  181 LLTIVMAMAL MHSKLDANLL SMVKENASES ARKLSLLCHK LLCLLDVFRY PNENTFTCLL 240
  241 YFYVSEHLDP ESPDCVLSPT NLLTLHHLLN LSMTLGLQYE PSKYKRFKDP EVIRQRRILW 300
  301 LGVQSLLFQI SLAEGDAGKS NSEYMEAYLT DFEEYIEASS EYEKSSASES NVQMNDIVWN 360
  361 KYKFHVILSK LMSDCTSVIQ HPQLFHILGN IKRSEDFMAE NFPTSSIYQP LHEK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [515-832]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EPNAIKVGKS TVLDVMDIQK TEIFLTNIVG SMCFLNIFDV LSLHFEKKCV MHWEEYEKNY  60
   61 HFLTLKSFNA YLKLAGLISD YLENKFQGNI LESRGYIIDK QICFMLVRIW MFQCRILLRF 120
  121 SYKQESQKKL ASSSISTNDN EKEDEMIVIL ERLIKHIRNQ MAHLVDLAKG KLQDSYFGAY 180
  181 QTVPMFRYVV YLIDVGGLVS VTNGFWDKIS SDGEIPPKVQ QAVRLKWGLD CNNSRRIKQK 240
  241 LISSQSLQSF NQVLLCQMED AVLSSSFAIK ANTAMSQNTA EEFFNISEEE ALNQLLENNN 300
  301 FDAFWDLLGE NLSDMPSL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle