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View Structure Prediction Details

Protein: HMRA1
Organism: Saccharomyces cerevisiae
Length: 126 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HMRA1.

Description E-value Query
Range
Subject
Range
HMRA1 - Silenced copy of a1 at HMR; homeobox corepressor that interacts with Alpha2p to repress haploid-spec...
HMRA1_YEAST - Silenced mating-type protein A1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HMRA1 PE...
2.0E-34 [1..126] [1..126]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
6.0E-33 [17..126] [83..193]
HXB7_BOVIN - Homeobox protein Hox-B7 OS=Bos taurus GN=HOXB7 PE=2 SV=1
6.0E-33 [17..126] [83..193]
HXB7_MOUSE - (P09024) Homeobox protein Hox-B7 (Hox-2.3) (MUB1) (MH-22B)
7.0E-33 [17..126] [83..193]
HOXB7 - homeobox B7
1.0E-32 [17..126] [83..193]
gi|4322040 - gi|4322040|gb|AAD15930.1| homeobox protein [Petromyzon marinus]
5.0E-31 [18..126] [107..218]
gi|15425738, gi|... - gi|15425738|dbj|BAB64346.1| homeotic protein [Daphnia magna], gi|109944931|dbj|BAE96993.1| Antennape...
1.0E-30 [12..126] [494..602]

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Predicted Domain #1
Region A:
Residues: [1-126]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDDICSMAEN INRTLFNILG TEIDEINLNT NNLYNFIMES NLTKVEQHTL HKNISNNRLE  60
   61 IYHHIKKEKS PKGKSSISPQ ARAFLEQVFR RKQSLNSKEK EEVAKKCGIT PLQVRVWFIN 120
  121 KRMRSK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 253.09691
Match: 1f43A_
Description: Mating type protein A1 Homeodomain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.51452285155271 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
sequence-specific DNA binding 2.41271657675151 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.26183812259792 bayes_pls_golite062009
transcription repressor activity 1.91962622287073 bayes_pls_golite062009
transcription activator activity 1.77700860354597 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.14886080629275 bayes_pls_golite062009
chromatin binding 1.04132983826241 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
protein binding 0.830419844171551 bayes_pls_golite062009
transcription corepressor activity 0.25931464844298 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle