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View Structure Prediction Details

Protein: TUP1
Organism: Saccharomyces cerevisiae
Length: 713 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TUP1.

Description E-value Query
Range
Subject
Range
gi|17225208 - gi|17225208|gb|AAL37300.1|AF323584_1 beta transducin-like protein HET-E2C*40 [Podospora anserina]
0.0 [219..712] [821..1253]
YY46_NOSS1 - Uncharacterized WD repeat-containing protein alr3466 OS=Nostoc sp. (strain PCC 7120 / UTEX 2576) GN=...
gi|25530855 - pir||AC2239 WD-40 repeat protein [imported] - Nostoc sp. (strain PCC 7120)
0.0 [197..712] [946..1486]

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Predicted Domain #1
Region A:
Residues: [1-281]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTASVSNTQN KLNELLDAIR QEFLQVSQEA NTYRLQNQKD YDFKMNQQLA EMQQIRNTVY  60
   61 ELELTHRKMK DAYEEEIKHL KLGLEQRDHQ IASLTVQQQR QQQQQQQVQQ HLQQQQQQLA 120
  121 AASASVPVAQ QPPATTSATA TPAANTTTGS PSAFPVQASR PNLVGSQLPT TTLPVVSSNA 180
  181 QQQLPQQQLQ QQQLQQQQPP PQVSVAPLSN TAINGSPTSK ETTTLPSVKA PESTLKETEP 240
  241 ENNNTSKIND TGSATTATTT TATETEIKPK EEDATPASLH Q

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 14.54
Match: 1ldvA
Description: No description for 1ldvA was found.

Predicted Domain #2
Region A:
Residues: [282-713]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DHYLVPYNQR ANHSKPIPPF LLDLDSQSVP DALKKQTNDY YILYNPALPR EIDVELHKSL  60
   61 DHTSVVCCVK FSNDGEYLAT GCNKTTQVYR VSDGSLVARL SDDSAANNHR NSITENNTTT 120
  121 STDNNTMTTT TTTTITTTAM TSAAELAKDV ENLNTSSSPS SDLYIRSVCF SPDGKFLATG 180
  181 AEDRLIRIWD IENRKIVMIL QGHEQDIYSL DYFPSGDKLV SGSGDRTVRI WDLRTGQCSL 240
  241 TLSIEDGVTT VAVSPGDGKY IAAGSLDRAV RVWDSETGFL VERLDSENES GTGHKDSVYS 300
  301 VVFTRDGQSV VSGSLDRSVK LWNLQNANNK SDSKTPNSGT CEVTYIGHKD FVLSVATTQN 360
  361 DEYILSGSKD RGVLFWDKKS GNPLLMLQGH RNSVISVAVA NGSPLGPEYN VFATGSGDCK 420
  421 ARIWKYKKIA PN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10079.69897
Match: 1erjA_
Description: Tup1, C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [211-281]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TAINGSPTSK ETTTLPSVKA PESTLKETEP ENNNTSKIND TGSATTATTT TATETEIKPK  60
   61 EEDATPASLH Q

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 71.69897
Match: 1p22A
Description: F-box/WD-repeat protein 1 (beta-TRCP1)
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [282-713]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DHYLVPYNQR ANHSKPIPPF LLDLDSQSVP DALKKQTNDY YILYNPALPR EIDVELHKSL  60
   61 DHTSVVCCVK FSNDGEYLAT GCNKTTQVYR VSDGSLVARL SDDSAANNHR NSITENNTTT 120
  121 STDNNTMTTT TTTTITTTAM TSAAELAKDV ENLNTSSSPS SDLYIRSVCF SPDGKFLATG 180
  181 AEDRLIRIWD IENRKIVMIL QGHEQDIYSL DYFPSGDKLV SGSGDRTVRI WDLRTGQCSL 240
  241 TLSIEDGVTT VAVSPGDGKY IAAGSLDRAV RVWDSETGFL VERLDSENES GTGHKDSVYS 300
  301 VVFTRDGQSV VSGSLDRSVK LWNLQNANNK SDSKTPNSGT CEVTYIGHKD FVLSVATTQN 360
  361 DEYILSGSKD RGVLFWDKKS GNPLLMLQGH RNSVISVAVA NGSPLGPEYN VFATGSGDCK 420
  421 ARIWKYKKIA PN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 86.39794
Match: 1erjA
Description: Tup1, C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
6.67009948605948 bayes_pls_golite062009
acetyltransferase activity 3.85374902981345 bayes_pls_golite062009
RNA binding 3.77273677738815 bayes_pls_golite062009
acyltransferase activity 3.35098520158193 bayes_pls_golite062009
actin binding 3.31804728298431 bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups 3.31615347567536 bayes_pls_golite062009
GTPase activity 3.23750443966606 bayes_pls_golite062009
transferase activity, transferring acyl groups 3.14917998298348 bayes_pls_golite062009
cytoskeletal protein binding 3.1056443224755 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 3.00422709839505 bayes_pls_golite062009
tubulin binding 2.76945430061825 bayes_pls_golite062009
microtubule binding 2.72684103222924 bayes_pls_golite062009
structural molecule activity 2.6914565031145 bayes_pls_golite062009
dynein binding 2.54821997913979 bayes_pls_golite062009
binding 2.42570478946173 bayes_pls_golite062009
transcription regulator activity 2.3610959773142 bayes_pls_golite062009
transcription repressor activity 2.29049708962212 bayes_pls_golite062009
snoRNA binding 2.27164613239345 bayes_pls_golite062009
nucleic acid binding 2.00420268007946 bayes_pls_golite062009
dynactin binding 1.92897254169098 bayes_pls_golite062009
DNA binding 1.71685536470455 bayes_pls_golite062009
actin filament binding 1.5197243426595 bayes_pls_golite062009
transcription corepressor activity 1.41752877005447 bayes_pls_golite062009
protein binding 1.21879977456466 bayes_pls_golite062009
transporter activity 1.21549336905926 bayes_pls_golite062009
receptor activity 1.12819778129653 bayes_pls_golite062009
transcription factor activity 1.08768505897883 bayes_pls_golite062009
mRNA binding 1.05053985350578 bayes_pls_golite062009
microtubule plus-end binding 1.01166033978052 bayes_pls_golite062009
molecular transducer activity 0.974380908248463 bayes_pls_golite062009
signal transducer activity 0.974380908248463 bayes_pls_golite062009
type 1 angiotensin receptor binding 0.920323565472959 bayes_pls_golite062009
angiotensin receptor binding 0.920323565472959 bayes_pls_golite062009
substrate-specific transporter activity 0.734793983890004 bayes_pls_golite062009
histone binding 0.685319917508843 bayes_pls_golite062009
transcription factor binding 0.489473003915035 bayes_pls_golite062009
dynein intermediate chain binding 0.443846546939402 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.426429095658617 bayes_pls_golite062009
kinase activity 0.387572734234845 bayes_pls_golite062009
transcription initiation factor activity 0.319410949467982 bayes_pls_golite062009
receptor binding 0.316169754698691 bayes_pls_golite062009
histone methyltransferase activity 0.311523647180993 bayes_pls_golite062009
transcription cofactor activity 0.30761651528651 bayes_pls_golite062009
nucleotidyltransferase activity 0.28606552120995 bayes_pls_golite062009
G-protein-coupled receptor binding 0.251120087240234 bayes_pls_golite062009
protein kinase activity 0.229242350006544 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.226335610368636 bayes_pls_golite062009
structural constituent of cytoskeleton 0.118975415284669 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.00585398682921312 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle