YRC Public Data Repository - Protein Structure Prediction

Protein:	SPB1
Organism:	Saccharomyces cerevisiae
Length:	841 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPB1.

Description	E-value	Query Range	Subject Range
gi\|151943780 - gi\|151943780\|gb\|EDN62080.1\| AdoMet-dependent rRNA methyltransferase [Saccharomyces cerevisiae YJM789... SPB1_YEAST - 27S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase OS=Saccharomyces cerevisiae (strain ATCC 20450... SPB1 - AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation;...	0.0	[1..841]	[1..841]
gi\|10954014 - gi\|10954014\|gb\|AAG25705.1\| SPB1-like protein [Saccharomyces servazzii]	0.0	[1..841]	[1..841]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[1..724]	[1..724]
SPB1_SCHPO - AdoMet-dependent rRNA methyltransferase spb1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) ... spb1 - rRNA methyltransferase Spb1	0.0	[1..836]	[1..799]
gi\|18028291 - gi\|18028291\|gb\|AAL56015.1\|AF327355_1 hypothetical protein SB92 [Homo sapiens]	4.0E-98	[1..829]	[1..834]
SPB1_MOUSE - pre-rRNA processing protein FTSJ3 OS=Mus musculus GN=Ftsj3 PE=1 SV=1	6.0E-93	[1..829]	[1..825]
SPB1_NEUCR - AdoMet-dependent rRNA methyltransferase spb1 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / ... SPB1_NEUCR - AdoMet-dependent rRNA methyltransferase spb-1 OS=Neurospora crassa GN=spb-1 PE=3 SV=2	2.0E-88	[5..837]	[4..831]

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Predicted Domain #1

Region A:
Residues: [1-204]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGKTQKKNSK GRLDRYYYLA KEKGYRARSS FKIIQINEKY GHFLEKSKVV IDLCAAPGSW  60
   61 CQVASKLCPV NSLIIGVDIV PMKPMPNVIT FQSDITTEDC RSKLRGYMKT WKADTVLHDG 120
  121 APNVGLGWVQ DAFTQSQLTL QALKLAVENL VVNGTFVTKI FRSKDYNKLI WVFQQLFEKV 180
  181 EATKPPASRN VSAEIFVVCK GFKA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	226.679424
Match:	1eizA_
Description:	RNA methyltransferase FtsJ
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
rRNA (guanine) methyltransferase activity	4.21285117944777	bayes_pls_golite062009
methyltransferase activity	4.15445027778357	bayes_pls_golite062009
rRNA methyltransferase activity	4.09362182773099	bayes_pls_golite062009
N-methyltransferase activity	4.07806017452628	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	4.07153733729662	bayes_pls_golite062009
protein methyltransferase activity	3.92746815303714	bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity	3.39429041855776	bayes_pls_golite062009
RNA methyltransferase activity	3.07428840534971	bayes_pls_golite062009
histone methyltransferase activity	2.99461585647365	bayes_pls_golite062009
DNA-methyltransferase activity	2.43145108778901	bayes_pls_golite062009
protein-arginine N-methyltransferase activity	2.41876112831625	bayes_pls_golite062009
arginine N-methyltransferase activity	2.41876112831625	bayes_pls_golite062009
transferase activity	2.22303238506686	bayes_pls_golite062009
histone-arginine N-methyltransferase activity	2.04296107639729	bayes_pls_golite062009
RNA binding	1.99752836873461	bayes_pls_golite062009
rRNA (adenine) methyltransferase activity	1.83964463328968	bayes_pls_golite062009
tRNA methyltransferase activity	1.76571145896453	bayes_pls_golite062009
rRNA (adenine-N6,N6-)-dimethyltransferase activity	1.75675289134467	bayes_pls_golite062009
protein-arginine omega-N monomethyltransferase activity	1.66871163498737	bayes_pls_golite062009
catalytic activity	1.25333584501255	bayes_pls_golite062009
histone methyltransferase activity (H4-R3 specific)	1.1103522853299	bayes_pls_golite062009
transcription regulator activity	0.914549843668268	bayes_pls_golite062009
rRNA (uridine-2'-O-)-methyltransferase activity	0.90544396691236	bayes_pls_golite062009
protein-arginine omega-N asymmetric methyltransferase activity	0.89325812193225	bayes_pls_golite062009
DNA binding	0.86027591375666	bayes_pls_golite062009
rRNA (uridine) methyltransferase activity	0.742142092552002	bayes_pls_golite062009
site-specific DNA-methyltransferase (adenine-specific) activity	0.703178429468566	bayes_pls_golite062009
tRNA (cytosine-5-)-methyltransferase activity	0.672282175551951	bayes_pls_golite062009
tRNA (cytosine)-methyltransferase activity	0.672282175551951	bayes_pls_golite062009
nucleic acid binding	0.616949327277483	bayes_pls_golite062009
binding	0.383237930789959	bayes_pls_golite062009
O-methyltransferase activity	0.250946859465502	bayes_pls_golite062009
rRNA (guanine-N1-)-methyltransferase activity	0.234572322347698	bayes_pls_golite062009
tRNA (adenine-N1-)-methyltransferase activity	0.1772047818218	bayes_pls_golite062009
tRNA (adenine)-methyltransferase activity	0.1772047818218	bayes_pls_golite062009
mRNA binding	0.0540207721800283	bayes_pls_golite062009
snoRNA binding	0.00848192089639488	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [205-532]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PKRLDPRLLD PKEVFEELPD GQQNMESKIY NPEKKVRKRQ GYEEGDNLLY HETSILDFVR  60
   61 TEDPISMLGE MNKFTIDEND HEWKILKKLK QTTDEFRSCI EDLKVLGKKD FKMILRWRKI 120
  121 AREILGIEVK DDAKTEIEVV PLTEEEQIEK DLQGLQEKQR LNVKRERRRK NEMKQKELQR 180
  181 MQMNMITPTD IGIEAASLGK ESLFNLKTAE KTGILNDLAK GKKRMIFTDD ELAKDNDIYI 240
  241 DENIMIKDKD SAADADDLES ELNAMYSDYK TRRSERDAKF RAKQARGGDN EEEWTGFNEG 300
  301 SLEKKEEEGK DYIEDNDDEG VEGDSDDD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	16.0
Match:	1i84S_
Description:	Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [533-629]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EAITNLISKL KGQEGDHKLS SKARMIFNDP IFNNVEPDLP VNTVNDGIMS SESVGDISKL  60
   61 NKKRKHEEMH QKQDEADSSD ESSSDDSDFE IVANDNA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	5.0
Match:	2tmaA_
Description:	Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [630-713]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SEEFDSDYDS EEEKNQTKKE KHSRDIDIAT VEAMTLAHQL ALGQKNKHDL VDEGFNRYTF  60
   61 RDTENLPDWF LEDEKEHSKI NKPI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	5.0
Match:	2tmaA_
Description:	Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #5

Region A:
Residues: [714-841]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TKEAAMAIKE KIKAMNARPI KKVAEAKARK RMRAVARLEK IKKKAGLIND DSDKTEKDKA  60
   61 EEISRLMRKV TKKPKTKPKV TLVVASGRNK GLAGRPKGVK GKYKMVDGVM KNEQRALRRI 120
  121 AKKHHKKK

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: