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View Structure Prediction Details

Protein: PGI1
Organism: Saccharomyces cerevisiae
Length: 554 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PGI1.

Description E-value Query
Range
Subject
Range
gi|68446 - pir||NUPG glucose-6-phosphate isomerase (EC 5.3.1.9) - pig
G6PI_PIG - Glucose-6-phosphate isomerase OS=Sus scrofa GN=GPI PE=1 SV=3
0.0 [9..552] [1..551]
G6PI_RABIT - Glucose-6-phosphate isomerase OS=Oryctolagus cuniculus GN=GPI PE=1 SV=3
0.0 [9..552] [1..551]
gi|123999183, gi... - gi|123999183|gb|ABM87172.1| glucose phosphate isomerase [synthetic construct], gi|123988669|gb|ABM83...
GPI - glucose-6-phosphate isomerase
0.0 [9..552] [1..551]
G6PI_MOUSE - Glucose-6-phosphate isomerase (EC 5.3.1.9) (GPI) (Phosphoglucose isomerase) (PGI) (Phosphohexose iso...
0.0 [9..552] [1..551]
G6PI_CRIGR - Glucose-6-phosphate isomerase OS=Cricetulus griseus GN=GPI PE=2 SV=1
0.0 [9..552] [1..551]

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Predicted Domain #1
Region A:
Residues: [1-108]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNNSFTNFK LATELPAWSK LQKIYESQGK TLSVKQEFQK DAKRFEKLNK TFTNYDGSKI  60
   61 LFDYSKNLVN DEIIAALIEL AKEANVTGLR DAMFKGEHIN STEDRAVY

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [309-516]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AEAVDNHFTQ TPLEDNIPLL GGLLSVWYNN FFGAQTHLVA PFDQYLHRFP AYLQQLSMES  60
   61 NGKSVTRGNV FTDYSTGSIL FGEPATNAQH SFFQLVHQGT KLIPSDFILA AQSHNPIENK 120
  121 LHQKMLASNF FAQAEALMVG KDEEQVKAEG ATGGLVPHKV FSGNRPTTSI LAQKITPATL 180
  181 GALIAYYEHV TFTEGAIWNI NSFDQWGV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11000.0
Match: 1gzdA_
Description: Phosphoglucose isomerase, PGI
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
glucose-6-phosphate isomerase activity 3.62042557708076 bayes_pls_golite062009
intramolecular oxidoreductase activity 2.12646274924126 bayes_pls_golite062009
intramolecular oxidoreductase activity, interconverting aldoses and ketoses 1.62962150339138 bayes_pls_golite062009
catalytic activity 1.5278037255884 bayes_pls_golite062009
sugar binding 1.40175307923331 bayes_pls_golite062009
glutamine-fructose-6-phosphate transaminase (isomerizing) activity 1.11549102314657 bayes_pls_golite062009
binding 1.0425673151455 bayes_pls_golite062009
D-sedoheptulose 7-phosphate isomerase activity 0.969046173332955 bayes_pls_golite062009
isomerase activity 0.875614547872629 bayes_pls_golite062009
carbohydrate binding 0.5730945843207 bayes_pls_golite062009
protein binding 0.152745336606766 bayes_pls_golite062009
transferase activity 0.0523744832826621 bayes_pls_golite062009
transferase activity, transferring nitrogenous groups 0.0239994594084577 bayes_pls_golite062009
transaminase activity 0.00531525548288503 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [109-308]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HVALRNRANK PMYVDGVNVA PEVDSVLKHM KEFSEQVRSG EWKGYTGKKI TDVVNIGIGG  60
   61 SDLGPVMVTE ALKHYAGVLD VHFVSNIDGT HIAETLKVVD PETTLFLIAS KTFTTAETIT 120
  121 NANTAKNWFL SKTGNDPSHI AKHFAALSTN ETEVAKFGID TKNMFGFESW VGGRYSVWSA 180
  181 IGLSVALYIG YDNFEAFLKG 

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [517-554]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ELGKVLAKVI GKELDNSSTI STHDASTNGL INQFKEWM

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11000.0
Match: 1gzdA_
Description: Phosphoglucose isomerase, PGI
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle