YRC Public Data Repository - Protein Structure Prediction

Protein:	SSE2
Organism:	Saccharomyces cerevisiae
Length:	693 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SSE2.

Description	E-value	Query Range	Subject Range
HSP70_TRIRU - Heat shock 70 kDa protein OS=Trichophyton rubrum GN=HSP70 PE=2 SV=1	0.0	[1..643]	[1..610]
gi\|6969976 - gi\|6969976\|gb\|AAF34134.1\| high molecular weight heat shock protein [Malus x domestica]	0.0	[2..673]	[7..650]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[2..673]	[6..641]
HSP7C_ICTPU - Heat shock cognate 71 kDa protein OS=Ictalurus punctatus GN=hsc70 PE=2 SV=1	0.0	[2..645]	[4..613]
HSP70_MAIZE, HS7... - Heat shock 70 kDa protein OS=Zea mays GN=HSP70 PE=3 SV=1, (P11143) Heat shock 70 kDa protein	0.0	[2..673]	[6..645]
gi\|3114993 - gi\|3114993\|emb\|CAA75383.1\| heat shock protein 70 [Sycon raphanus]	0.0	[4..644]	[3..609]
HS71B_BOVIN - Heat shock 70 kDa protein 1B OS=Bos taurus GN=HSPA1B PE=2 SV=1	0.0	[3..673]	[5..641]
gi\|7861932, gi\|1... - gi\|7861932\|gb\|AAF70445.1\| Hsp70 [Danio rerio], gi\|18858871\|ref\|NP_571472.1\| heat shock cognate 70-kd...	0.0	[2..670]	[6..640]
HSP7E_SPIOL - Chloroplast envelope membrane 70 kDa heat shock-related protein OS=Spinacia oleracea GN=SCE70 PE=1 S...	0.0	[2..671]	[7..645]
gi\|11024362 - gi\|11024362\|gb\|AAG26895.1\|AF295941_1 heat shock protein Hsp70Ab [Drosophila melanogaster]	0.0	[3..673]	[2..642]

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Predicted Domain #1

Region A:
Residues: [1-174]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTPFGLDLG NNNSVLAVAR NRGIDVVVNE VSNRSTPSLV GFGPRNRYLG ESGKTKQTSN  60
   61 VKNTVENLKR IIGLKFKDPE FDIENKFFTS KLVQLKNGKV GVEVEFGGKT HVFSATQLTA 120
  121 MFIDKVKHTV QEETKSSITD VCLAVPVWYS EEQRYNIADA ARIAGLNPVR IVND

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [369-385]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DEAVAKGAAF ICAIHSP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1625.228787
Match:	1hjoA_
Description:	Heat shock protein 70kDa, ATPase fragment
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
unfolded protein binding	4.93074236328581	bayes_pls_golite062009
structural constituent of cytoskeleton	2.46121037473545	bayes_pls_golite062009
structural molecule activity	2.37892721989886	bayes_pls_golite062009
carbohydrate kinase activity	2.33338276303563	bayes_pls_golite062009
cytoskeletal protein binding	2.20983242331685	bayes_pls_golite062009
binding	2.11855816699924	bayes_pls_golite062009
protein binding	2.00711904074672	bayes_pls_golite062009
hexokinase activity	1.70516840340504	bayes_pls_golite062009
transcription regulator activity	1.68670098354938	bayes_pls_golite062009
nucleic acid binding	1.43834016708999	bayes_pls_golite062009
peptidase activity	1.4127499531612	bayes_pls_golite062009
DNA binding	1.36804228074586	bayes_pls_golite062009
transporter activity	1.2883466875237	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	1.16749728168925	bayes_pls_golite062009
kinase activity	1.11102445353265	bayes_pls_golite062009
actin binding	1.03829083423378	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.953663805249074	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.900931843471417	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.898645342556399	bayes_pls_golite062009
pyrophosphatase activity	0.875671218597808	bayes_pls_golite062009
hydrolase activity	0.807017237368431	bayes_pls_golite062009
substrate-specific transporter activity	0.796517590178929	bayes_pls_golite062009
transcription factor activity	0.783439770973386	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.78242344952806	bayes_pls_golite062009
protein transporter activity	0.780308299678282	bayes_pls_golite062009
ATPase activity	0.687771333492666	bayes_pls_golite062009
myosin binding	0.607451856096	bayes_pls_golite062009
glucose binding	0.53527958884988	bayes_pls_golite062009
glucokinase activity	0.47468456642723	bayes_pls_golite062009
catalytic activity	0.296484721581333	bayes_pls_golite062009
chromatin binding	0.155140608043269	bayes_pls_golite062009
protease binding	0.121259015422625	bayes_pls_golite062009
chaperone binding	0.00111313452804307	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [175-235]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VTAAAVSYGV FKNDLPGPEE KPRIIGLVDI GHSTYTCSIM AFRKGEMKVL GTAYDKHFGG  60
   61 R

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [311-368]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EPLLKRVTYP ITNALAQAKL TVNDIDFVEI IGGTTRIPVL KKSISDVFGK PLSSTLNQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1625.228787
Match:	1hjoA_
Description:	Heat shock protein 70kDa, ATPase fragment
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [236-310]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DFDRAITEHF ADQFKDKYKI DIRKNPKAYN RILIAAEKLK KVLSANTTAP FSVESVMDDI  60
   61 DVSSQLSREE LEELV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1625.228787
Match:	1hjoA_
Description:	Heat shock protein 70kDa, ATPase fragment
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [386-566]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TLRVRPFKFE DIDPYSVSYT WDKQVDDEDR LEVFPANSSY PSTKLITLHR TGDFSMKAVY  60
   61 THPSKLPKGT STTIAKWSFT GVKVPKDQDF IPVKVKLRCD PSGLHIIENA YTTEDITVQE 120
  121 PVPLPEDAPE DAEPQFKEVT KTIKKDVLGM TAKTFALNPV ELNDLIEKEN ELRNQDKLVA 180
  181 E

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	77.69897
Match:	1dkyA_
Description:	DnaK
Matching Structure (courtesy of the PDB):

Predicted Domain #5

Region A:
Residues: [567-693]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TEDRKNALEE YIYTLRAKLD DEYSDFASDA EKEKLKNMLA TTENWLYGDG DDSTKAKYIA  60
   61 KYEELASLGN IIRGRYLAKE EEKRQALRAN QETSKMNDIA EKLAEQRRAR AASDDSDDNN 120
  121 DENMDLD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	77.69897
Match:	1dkyA_
Description:	DnaK
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: