YRC Public Data Repository - Protein Structure Prediction

Protein:	PTC4
Organism:	Saccharomyces cerevisiae
Length:	393 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PTC4.

Description	E-value	Query Range	Subject Range
PTC4 - Cytoplasmic type 2C protein phosphatase; identified as a high-copy number suppressor of the syntheti... gi\|190408719 - gi\|190408719\|gb\|EDV11984.1\| type 2C protein phosphatase [Saccharomyces cerevisiae RM11-1a] gi\|207347662 - gi\|207347662\|gb\|EDZ73760.1\| YBR125Cp-like protein [Saccharomyces cerevisiae AWRI1631] PP2C4_YEAST - Protein phosphatase 2C homolog 4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PTC4 PE... gi\|151946516 - gi\|151946516\|gb\|EDN64738.1\| protein phosphatase type 2C [Saccharomyces cerevisiae YJM789]	5.0E-90	[1..393]	[1..393]
PP2C2_SCHPO - Protein phosphatase 2C homolog 2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=ptc2 PE=3... ptc2 - protein phosphatase 2C Ptc2	3.0E-75	[1..391]	[1..313]
P2C21_ARATH - Probable protein phosphatase 2C 21 OS=Arabidopsis thaliana GN=PPC4-2 PE=1 SV=1	2.0E-73	[1..377]	[1..338]
CCDS9744.1_1 - null PPM1A - protein phosphatase, Mg2+/Mn2+ dependent, 1A gi\|114653343, gi... - gi\|114653347\|ref\|XP_509986.2\| PREDICTED: hypothetical protein LOC452950 isoform 9 [Pan troglodytes],... gi\|109083826, gi... - gi\|109083828\|ref\|XP_001096358.1\| PREDICTED: similar to protein phosphatase 1A isoform 1 isoform 5 [M... gi\|123996549, gi... - gi\|168279063\|dbj\|BAG11411.1\| protein phosphatase 1A [synthetic construct], gi\|123996549\|gb\|ABM85876....	8.0E-73	[1..381]	[1..304]
PPM1A_RABIT - Protein phosphatase 1A OS=Oryctolagus cuniculus GN=PPM1A PE=2 SV=1	9.0E-73	[1..381]	[1..304]
PPM1A_BOVIN - Protein phosphatase 1A OS=Bos taurus GN=PPM1A PE=2 SV=1	1.0E-72	[1..381]	[1..304]
PPM1A_RAT - Protein phosphatase 1A OS=Rattus norvegicus GN=Ppm1a PE=1 SV=1	2.0E-72	[1..381]	[1..304]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	4.0E-72	[1..389]	[1..315]

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Predicted Domain #1

Region A:
Residues: [1-393]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGQLLSHPLT EKTIEYNEYK NNQASTGIVP RFYNCVGSMQ GYRLTQEDAH LIRNENSVVY  60
   61 VRFFNPFIDK YETLSLNVFA VFDGHGGDDC SKFLSGGRHH RDGNGSSNGN GEPNAGLIKW 120
  121 IAYSFENHHY TSTTNNDSSK FKRSFNTLEG LVSQIFKDAF ILQDEELYRH FANSSCGSTA 180
  181 VVACIINEES LYVANCGDSR CILSSKSNGI KTMSFDHKPQ HIGELIRIND NGGTVSLGRV 240
  241 GGVLALSRAF SDFQFKRGVT YPHRRTKLTN ITQNLTYGTP PQEAQVTVEP DVLMHKIDYS 300
  301 KDEFLVLACD GIWDIYNNKQ LIHFIKYHLV SGTKLDTIIT KLLDHGIAQA NSNTGVGFDN 360
  361 MTAIIVVLNR KGETLQDWFN KMKTRLERER GLV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	336.70927
Match:	1a6q__
Description:	Protein serine/threonine phosphatase 2C, C-terminal domain; Protein serine/threonine phosphatase 2C, catalytic domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
phosphoprotein phosphatase activity	7.29765002420868	bayes_pls_golite062009
phosphatase activity	6.84540130415879	bayes_pls_golite062009
phosphoric ester hydrolase activity	6.63839066304808	bayes_pls_golite062009
protein serine/threonine phosphatase activity	6.20846750257603	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	5.76293366458633	bayes_pls_golite062009
hydrolase activity	2.93014592649821	bayes_pls_golite062009
binding	1.74689317666387	bayes_pls_golite062009
signal transducer activity	1.61688496161233	bayes_pls_golite062009
molecular transducer activity	1.61688496161233	bayes_pls_golite062009
catalytic activity	1.53401212718168	bayes_pls_golite062009
protein binding	1.47578617076714	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: