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View Structure Prediction Details

Protein: PRX1
Organism: Saccharomyces cerevisiae
Length: 261 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PRX1.

Description E-value Query
Range		 Subject
Range
PRX1_YEAST - Mitochondrial peroxiredoxin PRX1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PRX1 PE...
PRX1 - Mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin peroxidase activity, has a role in reductio...
gi|207347891 - gi|207347891|gb|EDZ73922.1| YBL064Cp-like protein [Saccharomyces cerevisiae AWRI1631]
gi|190408887 - gi|190408887|gb|EDV12152.1| peroxiredoxin [Saccharomyces cerevisiae RM11-1a]
gi|151946332 - gi|151946332|gb|EDN64554.1| peroxiredoxin [Saccharomyces cerevisiae YJM789]
 2.0E-72 [1..261] [1..261]
gi|19698783 - gi|19698783|gb|AAL91102.1| thiredoxin peroxidase [Acanthocheilonema viteae]
 2.0E-62 [45..249] [4..200]
BAS1B_ARATH - 2-Cys peroxiredoxin BAS1-like, chloroplastic OS=Arabidopsis thaliana GN=At5g06290 PE=2 SV=2
 2.0E-62 [2..243] [33..269]
gi|51980440 - gb|AAH82149.1| Unknown (protein for MGC:98395) [Xenopus laevis]
PRDX2_MOUSE - Peroxiredoxin-2 OS=Mus musculus GN=Prdx2 PE=1 SV=3
 4.0E-62 [49..244] [6..196]
gi|632720 - gi|632720|gb|AAB32034.1| TSA=thiol-specific antioxidant [rats, brain, Peptide, 198 aa]
PRDX2_RAT - Peroxiredoxin-2 OS=Rattus norvegicus GN=Prdx2 PE=1 SV=3
 5.0E-62 [51..244] [8..196]
gi|7339568 - gi|7339568|emb|CAB82860.1| 2-Cys-peroxiredoxin [Riccia fluitans]
 7.0E-62 [11..243] [44..273]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 7.0E-62 [49..244] [6..196]
gi|3193232 - gi|3193232|gb|AAC77922.1| peroxidoxin-2 [Onchocerca ochengi]
 7.0E-62 [45..248] [4..199]
gi|2352262 - gi|2352262|gb|AAB68798.1| peroxidoxin-1 [Dirofilaria immitis]
 1.0E-61 [45..248] [4..199]

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Predicted Domain #1
Region A:
Residues: [1-211] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFSRICSAQL KRTAWTLPKQ AHLQSQTIKT FATAPILCKQ FKQSDQPRLR INSDAPNFDA  60
   61 DTTVGKINFY DYLGDSWGVL FSHPADFTPV CTTEVSAFAK LKPEFDKRNV KLIGLSVEDV 120
  121 ESHEKWIQDI KEIAKVKNVG FPIIGDTFRN VAFLYDMVDA EGFKNINDGS LKTVRSVFVI 180
  181 DPKKKIRLIF TYPSTVGRNT SEVLRVIDAL Q

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 534.221849
Match: 1prxA_
Description: HorF6 peroxidase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
antioxidant activity 3.8464796631544 bayes_pls_golite062009
peroxidase activity 3.43831566988273 bayes_pls_golite062009
oxidoreductase activity, acting on peroxide as acceptor 3.43831566988273 bayes_pls_golite062009
selenium binding 2.92496040718744 bayes_pls_golite062009
glutathione peroxidase activity 2.56524997297011 bayes_pls_golite062009
transcription regulator activity 2.30799114442278 bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors 2.23310780102446 bayes_pls_golite062009
peroxiredoxin activity 2.12777217096121 bayes_pls_golite062009
thioredoxin peroxidase activity 1.96134566495756 bayes_pls_golite062009
protein disulfide oxidoreductase activity 1.47769936616412 bayes_pls_golite062009
alkyl hydroperoxide reductase activity 1.46071159007924 bayes_pls_golite062009
disulfide oxidoreductase activity 1.32811008894503 bayes_pls_golite062009
binding 1.25802922431343 bayes_pls_golite062009
protein binding 1.18479617596618 bayes_pls_golite062009
molecular transducer activity 1.11518182894524 bayes_pls_golite062009
signal transducer activity 1.11518182894524 bayes_pls_golite062009
catalytic activity 0.672192331361968 bayes_pls_golite062009
peptide binding 0.374493676068876 bayes_pls_golite062009
0.359224524631956 bayes_pls_golite062009
NADH dehydrogenase activity 0.23291471505999 bayes_pls_golite062009
copper ion binding 0.178842772364502 bayes_pls_golite062009
NADH dehydrogenase (ubiquinone) activity 0.16328723676608 bayes_pls_golite062009
NADH dehydrogenase (quinone) activity 0.0434052164026002 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [212-261] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LTDKEGVVTP INWQPADDVI IPPSVSNDEA KAKFGQFNEI KPYLRFTKSK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 534.221849
Match: 1prxA_
Description: HorF6 peroxidase
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle