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View Structure Prediction Details

Protein: NCL1
Organism: Saccharomyces cerevisiae
Length: 684 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NCL1.

Description E-value Query
Range		 Subject
Range
NCL1_YEAST - Multisite-specific tRNA:(cytosine-C(5))-methyltransferase OS=Saccharomyces cerevisiae (strain ATCC 2...
NCL1 - S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase, methylates cytosine to m5C at several...
 0.0 [1..684] [1..684]
SPAC23C4.17 - tRNA (cytosine-5-)-methyltransferase
YF6H_SCHPO - Putative tRNA (cytosine-5-)-methyltransferase C23C4.17 OS=Schizosaccharomyces pombe (strain 972 / AT...
 0.0 [12..636] [3..674]
CG6133-PA - This gene is referred to in FlyBase by the symbol Dmel\CG6133 (CG6133, FBgn0026079). It is a protein...
 0.0 [3..646] [5..674]
gi|15489014 - gi|15489014|gb|AAH13625.1| Nsun2 protein [Mus musculus]
 0.0 [225..682] [2..517]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 4.0E-91 [3..490] [187..620]
gi|19170955, gi|... - gi|19173366|ref|NP_597169.1| PUTATIVE METHYLTRANSFERASE [Encephalitozoon cuniculi GB-M1], gi|1917095...
gi|19173366 - gi|19173366|ref|NP_597169.1| PUTATIVE METHYLTRANSFERASE [Encephalitozoon cuniculi GB-M1]
 7.0E-85 [35..575] [4..465]
gi|189422 - gi|189422|gb|AAA36398.1| proliferating cell nuclear protein P120
 1.0E-81 [3..442] [255..635]

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Predicted Domain #1
Region A:
Residues: [1-74] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MARRKNFKKG NKKTFGARDD SRAQKNWSEL VKENEKWEKY YKTLALFPED QWEEFKKTCQ  60
   61 APLPLTFRIT GSRK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score		 SCOP
Match		 SCOP Description
View Download 0.274 a.6.1 Putative DNA-binding domain
View Download 0.327 a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.334 a.64.1 Saposin
View Download 0.314 d.43.1 Elongation factor Ts (EF-Ts), dimerisation domain
View Download 0.304 a.112.1 Description not found.
View Download 0.260 a.64.2 Bacteriocin AS-48
View Download 0.220 a.179.1 Replisome organizer (g39p helicase loader/inhibitor protein)

Predicted functions:

Term Confidence Notes
methyltransferase activity 4.15445027778357 bayes_pls_golite062009
N-methyltransferase activity 4.07806017452628 bayes_pls_golite062009
transferase activity, transferring one-carbon groups 4.07153733729662 bayes_pls_golite062009
protein methyltransferase activity 3.92746815303714 bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity 3.39429041855776 bayes_pls_golite062009
RNA methyltransferase activity 3.07428840534971 bayes_pls_golite062009
histone methyltransferase activity 2.99461585647365 bayes_pls_golite062009
transferase activity 2.926540904444 bayes_pls_golite062009
tRNA methyltransferase activity 2.5931020126592 bayes_pls_golite062009
DNA-methyltransferase activity 2.43145108778901 bayes_pls_golite062009
arginine N-methyltransferase activity 2.41876112831625 bayes_pls_golite062009
protein-arginine N-methyltransferase activity 2.41876112831625 bayes_pls_golite062009
rRNA methyltransferase activity 2.29640050660273 bayes_pls_golite062009
histone-arginine N-methyltransferase activity 2.04296107639729 bayes_pls_golite062009
tRNA (cytosine-5-)-methyltransferase activity 1.88889414729709 bayes_pls_golite062009
tRNA (cytosine)-methyltransferase activity 1.88889414729709 bayes_pls_golite062009
protein-arginine omega-N monomethyltransferase activity 1.66871163498737 bayes_pls_golite062009
tRNA (adenine-N1-)-methyltransferase activity 1.29759910099835 bayes_pls_golite062009
tRNA (adenine)-methyltransferase activity 1.29759910099835 bayes_pls_golite062009
catalytic activity 1.25333584501255 bayes_pls_golite062009
histone methyltransferase activity (H4-R3 specific) 1.1103522853299 bayes_pls_golite062009
transcription regulator activity 0.914549843668268 bayes_pls_golite062009
protein-arginine omega-N asymmetric methyltransferase activity 0.89325812193225 bayes_pls_golite062009
DNA binding 0.86027591375666 bayes_pls_golite062009
rRNA (guanine) methyltransferase activity 0.720972789045101 bayes_pls_golite062009
site-specific DNA-methyltransferase (adenine-specific) activity 0.703178429468566 bayes_pls_golite062009
nucleic acid binding 0.616949327277483 bayes_pls_golite062009
rRNA (adenine) methyltransferase activity 0.533090627724779 bayes_pls_golite062009
rRNA (adenine-N6,N6-)-dimethyltransferase activity 0.455449410561251 bayes_pls_golite062009
RNA binding 0.417524996559564 bayes_pls_golite062009
binding 0.383237930789959 bayes_pls_golite062009
protein-arginine omega-N symmetric methyltransferase activity 0.364369105571521 bayes_pls_golite062009
tRNA (guanine) methyltransferase activity 0.203168546434167 bayes_pls_golite062009
rRNA (uridine) methyltransferase activity 0.0858581024725429 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [75-146] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HAGEVLNLFK ERHLPNLTNV EFEGEKIKAP VELPWYPDHL AWQLDVPKTV IRKNEQFAKT  60
   61 QRFLVVENAV GN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.69897
Match: 1fbnA_
Description: Fibrillarin homologue
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [147-364] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ISRQEAVSMI PPIVLEVKPH HTVLDMCAAP GSKTAQLIEA LHKDTDEPSG FVVANDADAR  60
   61 RSHMLVHQLK RLNSANLMVV NHDAQFFPRI RLHGNSNNKN DVLKFDRILC DVPCSGDGTM 120
  121 RKNVNVWKDW NTQAGLGLHA VQLNILNRGL HLLKNNGRLV YSTCSLNPIE NEAVVAEALR 180
  181 KWGDKIRLVN CDDKLPGLIR SKGVSKWPVY DRNLTEKT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 164.10721
Match: 1j4fA_
Description: No description for 1j4fA_ was found.

Predicted Domain #4
Region A:
Residues: [365-494] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KGDEGTLDSF FSPSEEEASK FNLQNCMRVY PHQQNTGGFF ITVFEKVEDS TEAATEKLSS  60
   61 ETPALESEGP QTKKIKVEEV QKKERLPRDA NEEPFVFVDP QHEALKVCWD FYGIDNIFDR 120
  121 NTCLVRNATG

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score		 GO
Score		 GO
Term		 SCOP
Match		 SCOP Description
View Download 0.220 0.552 nucleus a.118.8 TPR-like
View Download 0.575 0.000 nucleus c.13.2 Anti-sigma factor antagonist SpoIIaa

Predicted Domain #5
Region A:
Residues: [495-684] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EPTRVVYTVC PALKDVIQAN DDRLKIIYSG VKLFVSQRSD IECSWRIQSE SLPIMKHHMK  60
   61 SNRIVEANLE MLKHLLIESF PNFDDIRSKN IDNDFVEKMT KLSSGCAFID VSRNDPAKEN 120
  121 LFLPVWKGNK CINLMVCKED THELLYRIFG IDANAKATPS AEEKEKEKET TESPAETTTG 180
  181 TSTEAPSAAN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle