YRC Public Data Repository - Protein Structure Prediction

Protein:	ACH1
Organism:	Saccharomyces cerevisiae
Length:	526 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ACH1.

Description	E-value	Query Range	Subject Range
ACH1 - Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate;... ACH1_YEAST - Acetyl-CoA hydrolase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ACH1 PE=1 SV=2 gi\|190408841 - gi\|190408841\|gb\|EDV12106.1\| acetyl CoA hydrolase [Saccharomyces cerevisiae RM11-1a] gi\|151946380 - gi\|151946380\|gb\|EDN64602.1\| acetyl CoA hydrolase [Saccharomyces cerevisiae YJM789]	0.0	[1..526]	[1..526]
SPAC1952.09c - acetyl-CoA hydrolase ACH1_SCHPO - Acetyl-CoA hydrolase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=ach1 PE=2 SV=1	0.0	[5..522]	[3..521]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[8..519]	[4..498]
gi\|189019792, gi... - gi\|189024220\|ref\|YP_001934988.1\| Acetyl-CoA hydrolase/transferase [Brucella abortus S19], gi\|1890197... gi\|163674048, gi... - gi\|163843325\|ref\|YP_001627729.1\| Acetyl-CoA hydrolase [Brucella suis ATCC 23445], gi\|163674048\|gb\|AB... gi\|161619008, gi... - gi\|161619008\|ref\|YP_001592895.1\| Acetyl-CoA hydrolase [Brucella canis ATCC 23365], gi\|161335819\|gb\|A... gi\|148372004, gi... - gi\|148560747\|ref\|YP_001258992.1\| acetyl-CoA hydrolase/transferase family protein [Brucella ovis ATCC... gi\|225617538, gi... - gi\|225627533\|ref\|ZP_03785570.1\| Acetyl-CoA hydrolase [Brucella ceti str. Cudo], gi\|225617538\|gb\|EEH1... gi\|237790318, gi... - gi\|237815481\|ref\|ZP_04594479.1\| succinate CoA transferase [Brucella abortus str. 2308 A], gi\|2377903... gi\|225640926, gi... - gi\|225852561\|ref\|YP_002732794.1\| succinate CoA transferase [Brucella melitensis ATCC 23457], gi\|2256... gi\|254693770 - gi\|254693770\|ref\|ZP_05155598.1\| succinate CoA transferase [Brucella abortus bv. 3 str. Tulya] gi\|254689286 - gi\|254689286\|ref\|ZP_05152540.1\| succinate CoA transferase [Brucella abortus bv. 6 str. 870] gi\|254701805 - gi\|254701805\|ref\|ZP_05163633.1\| succinate CoA transferase [Brucella suis bv. 5 str. 513] gi\|254697422 - gi\|254697422\|ref\|ZP_05159250.1\| succinate CoA transferase [Brucella abortus bv. 2 str. 86/8/59] gi\|254710140 - gi\|254710140\|ref\|ZP_05171951.1\| succinate CoA transferase [Brucella pinnipedialis B2/94] gi\|82699906 - gi\|82699906\|ref\|YP_414480.1\| Acetyl-CoA hydrolase/transferase [Brucella melitensis biovar Abortus 23... gi\|254706754 - gi\|254706754\|ref\|ZP_05168582.1\| succinate CoA transferase [Brucella pinnipedialis M163/99/10] gi\|62196110, gi\|... - gi\|62289978\|ref\|YP_221771.1\| acetyl-CoA hydrolase/transferase family protein [Brucella abortus bv. 1... gi\|82616007 - gi\|82616007\|emb\|CAJ11033.1\| Acetyl-CoA hydrolase/transferase [Brucella melitensis biovar Abortus 230... gi\|254730320 - gi\|254730320\|ref\|ZP_05188898.1\| succinate CoA transferase [Brucella abortus bv. 4 str. 292] gi\|25324446 - pir\|\|AB3368 acetate CoA-transferase (EC 2.8.3.8) [imported] - Brucella melitensis (strain 16M) gi\|23347881, gi\|... - gi\|23501936\|ref\|NP_698063.1\| acetyl-CoA hydrolase/transferase family protein [Brucella suis 1330], g... gi\|17982882, gi\|... - gi\|17987211\|ref\|NP_539845.1\| acetate CoA-transferase alpha subunit [Brucella melitensis 16M], gi\|179...	0.0	[6..518]	[1..495]
ACH1_NEUCR - Acetyl-CoA hydrolase OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / ... ACH1_NEUCR - Acetyl-CoA hydrolase OS=Neurospora crassa GN=acu-8 PE=3 SV=2	0.0	[10..517]	[11..520]
gi\|17738737, gi\|... - gi\|17934311\|ref\|NP_531101.1\| coenzyme A transferase [Agrobacterium tumefaciens str. C58], gi\|1773873... gi\|25324444 - pir\|\|AC2625 coenzyme A transferase [imported] - Agrobacterium tumefaciens (strain C58, Dupont)	0.0	[6..517]	[1..494]
gi\|219569731, gi... - gi\|219856007\|ref\|YP_002473129.1\| hypothetical protein CKR_2664 [Clostridium kluyveri NBRC 12016], gi... CAT1_CLOK5 - Succinyl-CoA:coenzyme A transferase OS=Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 1068... CAT1_CLOKL - Succinyl-CoA:coenzyme A transferase - Clostridium kluyveri	0.0	[4..518]	[39..538]
gi\|84318138, gi\|... - gi\|84318138\|ref\|ZP_00966567.1\| COG0427: Acetyl-CoA hydrolase [Pseudomonas aeruginosa C3719], gi\|2542... gi\|84324910, gi\|... - gi\|84324910\|ref\|ZP_00972962.1\| COG0427: Acetyl-CoA hydrolase [Pseudomonas aeruginosa 2192], gi\|25424... gi\|115588816, gi... - gi\|32043009\|ref\|ZP_00140271.1\| COG0427: Acetyl-CoA hydrolase [Pseudomonas aeruginosa UCBPP-PA14], gi... gi\|9951775, gi\|1... - gi\|9951775\|gb\|AAG08830.1\|AE004957_5 probable coenzyme A transferase [Pseudomonas aeruginosa PAO1], g... gi\|11351199 - pir\|\|B82966 probable coenzyme A transferase PA5445 [imported] - Pseudomonas aeruginosa (strain PAO1) gi\|218774777, gi... - gi\|218894548\|ref\|YP_002443418.1\| putative coenzyme A transferase [Pseudomonas aeruginosa LESB58], gi... gi\|107104549 - gi\|107104549\|ref\|ZP_01368467.1\| hypothetical protein PaerPA_01005627 [Pseudomonas aeruginosa PACS2]	0.0	[6..517]	[1..494]

Back

Predicted Domain #1

Region A:
Residues: [1-234]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTISNLLKQR VRYAPYLKKV KEAHELIPLF KNGQYLGWSG FTGVGTPKAV PEALIDHVEK  60
   61 NNLQGKLRFN LFVGASAGPE ENRWAEHDMI IKRAPHQVGK PIAKAINQGR IEFFDKHLSM 120
  121 FPQDLTYGFY TRERKDNKIL DYTIIEATAI KEDGSIVPGP SVGGSPEFIT VSDKVIIEVN 180
  181 TATPSFEGIH DIDMPVNPPF RKPYPYLKVD DKCGVDSIPV DPEKVVAIVE STMR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	34.045757
Match:	1k6dA_
Description:	Acetate:CoA transferase alpha
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	1.31732715713197	bayes_pls_golite062009
transferase activity, transferring sulfur-containing groups	0.768278195752223	bayes_pls_golite062009
acetyl-CoA hydrolase activity	0.73627161929319	bayes_pls_golite062009
CoA hydrolase activity	0.54582496937776	bayes_pls_golite062009
ribose-5-phosphate isomerase activity	0.433191582711132	bayes_pls_golite062009
nucleic acid binding	0.209863122534786	bayes_pls_golite062009
intramolecular oxidoreductase activity, interconverting aldoses and ketoses	0.197609066179683	bayes_pls_golite062009
CoA-transferase activity	0.0320953696548698	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [235-526]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DQVPPNTPSD DMSRAIAGHL VEFFRNEVKH GRLPENLLPL QSGIGNIANA VIEGLAGAQF  60
   61 KHLTVWTEVL QDSFLDLFEN GSLDYATATS VRLTEKGFDR AFANWENFKH RLCLRSQVVS 120
  121 NNPEMIRRLG VIAMNTPVEV DIYAHANSTN VNGSRMLNGL GGSADFLRNA KLSIMHAPSA 180
  181 RPTKVDPTGI STIVPMASHV DQTEHDLDIL VTDQGLADLR GLSPKERARE IINKCAHPDY 240
  241 QALLTDYLDR AEHYAKKHNC LHEPHMLKNA FKFHTNLAEK GTMKVDSWEP VD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	5.0
Match:	1poiB_
Description:	Glutaconate:CoA transferase beta
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: