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View Structure Prediction Details

Protein: AI3
Organism: Saccharomyces cerevisiae
Length: 403 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for AI3.

Description E-value Query
Range
Subject
Range
gi|57161732|emb|... - putative DNA endonuclease [Kluyveromyces thermotolerans], putative DNA endonuclease [Kluyveromyces t...
gi|57790526, gi|... - gi|57790526|ref|YP_184722.1| putative DNA endonuclease [Kluyveromyces thermotolerans], gi|57161732|e...
251.0 [0..1] [403..1]

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Predicted Domain #1
Region A:
Residues: [1-114]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVQRWLYSTN AKDIAVLYFM LAIFSGMAGT AMSLIIRLEL AAPGSQYLHG NSQLFNVLVM  60
   61 PALIGGFGNQ KRYESNNNNN QVMENKEYNL KLNYDKLGPY LAGLIEGDGT ITVQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 44.522879
Match: 1occA
Description: Mitochondrial cytochrome c oxidase, subunit I
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [115-403]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NSSSMKKSKY RPLIVVVFKL EDLELANYLC NLTKCGKVYK KINRNYVLWT IHDLKGVYTL  60
   61 LNIINGYMRT PKYEAFVRGA EFMNNYINST TITHNKLKNM DNIKIKPLDT SDIGSNAWLA 120
  121 GMTDADGNFS INLMNGKNRS SRAMPYYCLE LRQNYQKNSN NNNINFSYFY IMSAIATYFN 180
  181 VNLYSRERNL NLLVSTNNTY KTYYSYKVMV ANTYKNIKVM EYFNKYSLLS SKHLDFLDWS 240
  241 KLVILINNEG QSMKTNGSWE LGMNLRKDYN KTRTTFTWSH LKNTYLENK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 16.154902
Match: 1p8kZ
Description: The structure and DNA recognition of a bifunctional homing endonuclease and group I intron splicing factor
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
nuclease activity 1.30590086180382 bayes_pls_golite062009
catalytic activity 1.00294942392567 bayes_pls_golite062009
binding 0.947409481120466 bayes_pls_golite062009
hydrolase activity 0.908706495902542 bayes_pls_golite062009
endonuclease activity 0.892525491806151 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 0.861094108940112 bayes_pls_golite062009
nucleic acid binding 0.59572260756409 bayes_pls_golite062009
DNA binding 0.156232940245275 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle