YRC Public Data Repository - Protein Structure Prediction

Protein:	NNT1_SCHPO
Organism:	Schizosaccharomyces pombe 972h-
Length:	255 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NNT1_SCHPO.

Description	E-value	Query Range	Subject Range
NNT1 - Putative nicotinamide N-methyltransferase, has a role in rDNA silencing and in lifespan determinatio... NNT1_YEAST - Protein N-methyltransferase NNT1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NNT1 PE...	148.0	[0..1]	[250..1]
gi\|46098803, gi\|... - gi\|71017903\|ref\|XP_759182.1\| hypothetical protein UM03035.1 [Ustilago maydis 521], ref\|XP_400650.1\| ...	147.0	[0..2]	[253..1172]
gi\|238879837 - gi\|238879837\|gb\|EEQ43475.1\| hypothetical protein CAWG_01712 [Candida albicans WO-1] NNT1_CANAL - Protein N-methyltransferase NNT1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=NNT1 PE=3 SV... NNT1_CANAL - Putative nicotinamide N-methyltransferase OS=Candida albicans GN=NNT1 PE=3 SV=1	146.0	[0..2]	[249..3]
NNT1_CANGA - Protein N-methyltransferase NNT1 OS=Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0... NNT1_CANGA - Putative nicotinamide N-methyltransferase OS=Candida glabrata GN=NNT1 PE=3 SV=1	144.0	[0..1]	[250..1]
NNT1_ASPFU - Protein N-methyltransferase nnt1 OS=Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 ... NNT1_ASPFU - Putative nicotinamide N-methyltransferase OS=Aspergillus fumigatus GN=nnt1 PE=3 SV=1 gi\|159127233 - gi\|159127233\|gb\|EDP52348.1\| nicotinamide N-methyltransferase Nnt1, putative [Aspergillus fumigatus A...	143.0	[0..3]	[251..4]
gi\|83770659 - gi\|83770659\|dbj\|BAE60792.1\| unnamed protein product [Aspergillus oryzae] gi\|169763462 - gi\|169763462\|ref\|XP_001727631.1\| hypothetical protein [Aspergillus oryzae RIB40]	140.0	[0..1]	[251..1]
NNT1_NEUCR - Protein N-methyltransferase nnt1 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 /... NNT1_NEUCR - Putative nicotinamide N-methyltransferase OS=Neurospora crassa GN=nnt-1 PE=3 SV=1	137.0	[0..2]	[252..15]
gi\|111060862 - gi\|111060862\|gb\|EAT81982.1\| hypothetical protein SNOG_10588 [Phaeosphaeria nodorum SN15]	135.0	[0..2]	[253..3]
NNT1_KLULA - Putative nicotinamide N-methyltransferase OS=Kluyveromyces lactis GN=NNT1 PE=3 SV=1 NNT1_KLULA - Protein N-methyltransferase NNT1 OS=Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / ...	134.0	[0..1]	[249..1]
gi\|38102124, gi\|... - gi\|39974391\|ref\|XP_368586.1\| hypothetical protein MGG_00658 [Magnaporthe grisea 70-15], gb\|EAA49000....	134.0	[0..2]	[252..16]

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Predicted Domain #1

Region A:
Residues: [1-255]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MADNDFEGFG IFEEPEGFRP STPPPKEVLH TRVIVPNGPE EIKLRLVGSH SLWAHYLWNS  60
   61 GIELANYIDK NPDTVRAKKV LELGAGAGLP SIVSAFDGAK FVVSTDYPDP ALIDNLEHNV 120
  121 KQYAEIASKI SAVGYLWGSN IKEVMSNAGF KDNEVFDILL LSDLVFNHTE HSKLIKSCKM 180
  181 AIEGNPNAVV YVFFTHHRPH LAKKDMIFFD IAQSEGFQIE KILEEKRTPM FEEDPGAPEI 240
  241 RATVHGYKMT IPIPV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	25.0
Match:	1uwvA
Description:	Crystal Structure of RumA, the iron-sulfur cluster containing E. coli 23S Ribosomal RNA 5-Methyluridine Methyltransferase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transferase activity	1.77671966857605	bayes_pls_golite062009
DNA-methyltransferase activity	1.4114792557994	bayes_pls_golite062009
catalytic activity	1.25333584501255	bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity	1.07629237539972	bayes_pls_golite062009
methyltransferase activity	1.06467956103007	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	1.04881630872808	bayes_pls_golite062009
transcription regulator activity	0.978540537169703	bayes_pls_golite062009
DNA binding	0.905031018963259	bayes_pls_golite062009
nucleic acid binding	0.848300230574943	bayes_pls_golite062009
histone methyltransferase activity	0.718593815666209	bayes_pls_golite062009
site-specific DNA-methyltransferase (adenine-specific) activity	0.488694756043017	bayes_pls_golite062009
RNA methyltransferase activity	0.473668177706488	bayes_pls_golite062009
N-methyltransferase activity	0.344664739778274	bayes_pls_golite062009
binding	0.336188540273603	bayes_pls_golite062009
protein-arginine omega-N symmetric methyltransferase activity	0.155715313885332	bayes_pls_golite062009
histone methyltransferase activity (H4-R3 specific)	0.0598613771472298	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: