YRC Public Data Repository - Protein Structure Prediction

Protein:	GCH1_SCHPO
Organism:	Schizosaccharomyces pombe 972h-
Length:	235 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GCH1_SCHPO.

Description	E-value	Query Range	Subject Range
gi\|49645805, gi\|... - gi\|50543548\|ref\|XP_499940.1\| hypothetical protein [Yarrowia lipolytica], gi\|49645805\|emb\|CAG83867.1\|...	340.0	[0..11]	[234..77]
gi\|49658095 - gi\|49658095\|emb\|CAG90935.1\| DEHA2G20306p [Debaryomyces hansenii] gi\|49658095, gi\|... - gi\|50427625\|ref\|XP_462425.1\| hypothetical protein DEHA0G21593g [Debaryomyces hansenii CBS767], gi\|49...	337.0	[0..11]	[234..42]
gi\|68468054, gi\|... - gi\|68468054\|ref\|XP_721866.1\| hypothetical protein CaO19.3957 [Candida albicans SC5314], gi\|68467735\|... orf19.11439, orf... - orf19.3957 CGDID:CAL0003014 Assembly 19, Contig19-10194 (107807, 106977) CDS, reverse complemented, ...	337.0	[0..6]	[230..49]
gi\|119183093, gi... - gi\|90301406\|gb\|EAS31037.1\| GTP cyclohydrolase I [Coccidioides immitis RS], gi\|119183093\|ref\|XP_00124... gi\|240109490 - gi\|240109490\|gb\|EER27659.1\| GTP cyclohydrolase I, putative [Coccidioides posadasii C735 delta SOWgp]	332.0	[0..8]	[234..109]
gi\|255061 - gi\|255061\|gb\|AAB23164.1\| GTP cyclohydrolase I [Homo sapiens]	330.0	[0..14]	[233..18]
GCH1_NOSP7 - GTP cyclohydrolase 1 OS=Nostoc punctiforme (strain ATCC 29133 / PCC 73102) GN=folE PE=3 SV=1	330.0	[0..7]	[233..10]
gi\|49525645 - gi\|49525645\|emb\|CAG59262.1\| unnamed protein product [Candida glabrata] gi\|50287817, gi\|... - gi\|50287817\|ref\|XP_446338.1\| unnamed protein product [Candida glabrata], gi\|49525645\|emb\|CAG59262.1\|...	329.0	[0..11]	[234..17]
gi\|25290301 - pir\|\|AG2466 GTP cyclohydrolase I [imported] - Nostoc sp. (strain PCC 7120) GCH11_NOSS1 - GTP cyclohydrolase 1 1 OS=Nostoc sp. (strain PCC 7120 / UTEX 2576) GN=folE1 PE=3 SV=1	329.0	[0..7]	[233..10]
gi\|75702476, gi\|... - gi\|75908751\|ref\|YP_323047.1\| GTP cyclohydrolase I [Anabaena variabilis ATCC 29413], gi\|75702476\|gb\|A...	329.0	[0..7]	[233..10]

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Predicted Domain #1

Region A:
Residues: [1-235]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEPGKKDYID SPLRMQPASL SGASTPTIDL DGLSWPCQGT QRRIDTAEEE KVKKISNAIS  60
   61 TILECLGEDP ERQGLLGTPE RYAKAMLYFT KGYEQNLTEV INEAVFQEDH EEMVIVRDID 120
  121 VFSLCEHHLV PFIGKIHIGY IPRKRVLGLS KLARIANMFS RRLQVQERLT KQVAQAIQAV 180
  181 LKPQGVAVVM EATHMCMVMR GVEKPGSSTV TSSLTGIFQR SHKTREEFFR LIGKF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	88.045757
Match:	1is7A
Description:	GTP cyclohydrolase I
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
GTP cyclohydrolase I activity	5.27071565931386	bayes_pls_golite062009
cyclohydrolase activity	3.66553359909123	bayes_pls_golite062009
GTP cyclohydrolase activity	3.44912994722205	bayes_pls_golite062009
6-pyruvoyltetrahydropterin synthase activity	2.94513271787536	bayes_pls_golite062009
catalytic activity	2.20788162511962	bayes_pls_golite062009
hydrolase activity	1.99585429337181	bayes_pls_golite062009
dihydroneopterin aldolase activity	1.96466418682643	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	1.73101699306211	bayes_pls_golite062009
binding	1.62520629128577	bayes_pls_golite062009
protein binding	1.34873192832825	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	0.974891318710762	bayes_pls_golite062009
carbon-carbon lyase activity	0.25616855487144	bayes_pls_golite062009
urate oxidase activity	0.0294957696532921	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: