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View Structure Prediction Details

Protein: cfz-2
Organism: Caenorhabditis elegans
Length: 578 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for cfz-2.

Description E-value Query
Range
Subject
Range
gi|76661271 - gi|76661271|ref|XP_602576.2| PREDICTED: similar to frizzled 7 [Bos taurus]
341.0 [0..11] [539..476]

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Predicted Domain #1
Region A:
Residues: [1-177]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLLRISVLFL LLGSCGALFG KRQKCEQITI PLCKGIGYNM TSFPNSYGHE KQEEAGLEVH  60
   61 QFYPLVEVGC FQHLKFFLCT MYTPICQENY DKPILPCMEL CVEARSKCSP IMAKYGFRWP 120
  121 ETLSCEALPK MSDQMSTGNI CAAPPDTPKK QHKGHHHKNQ NQNQNQNHNY SPDGPEV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 37.221849
Match: 1ijyA
Description: Frizzled 8 (FZ8)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
Wnt receptor activity 5.34849208575619 bayes_pls_golite062009
Wnt-protein binding 4.48351937520811 bayes_pls_golite062009
transmembrane receptor activity 4.38708793497137 bayes_pls_golite062009
receptor activity 4.1046853496316 bayes_pls_golite062009
signal transducer activity 3.17034085692897 bayes_pls_golite062009
molecular transducer activity 3.17034085692897 bayes_pls_golite062009
binding 1.75284371400205 bayes_pls_golite062009
protein binding 1.1012033332744 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [178-578]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GISKIDNEVI AGPSECQCTC NQPFQFVASE KSKVGNVTNC AYSCHSPALA ESHSLVSNWM  60
   61 AFWSITCCVL ASFTFLTFLI ETDRFQYPER PIFMLAFCQL MVAVGFMIRY FVGHEEIACD 120
  121 SMRIKGADDN SGSLCFVVFL LTYFFGMAAS VWWVILSLTW VLSAASKWSP EAISSFSFHF 180
  181 HVVGWCLPAI QTVLVIVFNA IDGDPITGIC YVGNTDLQFQ RIFVLFPLLV YFIVGVLFLV 240
  241 IGFCNLWSIR NEVQKQHPSL ESAHKITQLM SKIGIFSLLY TIPSLLIICV LFYEQNHRSL 300
  301 WEQSQLCSCS PKQTIGDSSL IISLIKTCCM CILGWTSGFW VCSTKTLSSW KNAICCLGSS 360
  361 RSLPKYQPAD ILYAKSDMSS SQFYNTSLRH NHLYGGIPDK L

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 45.522879
Match: 1f88A
Description: Rhodopsin
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle