YRC Public Data Repository - Protein Structure Prediction

Protein:	CYSK_ECOLI
Organism:	Escherichia coli
Length:	323 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CYSK_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|70728897, gi\|... - gi\|70728897\|ref\|YP_258646.1\| cysteine synthase A [Pseudomonas fluorescens Pf-5], gi\|68343196\|gb\|AAY9...	365.0	[0..1]	[323..46]
gi\|157155432, gi... - gi\|75187168\|ref\|ZP_00700435.1\| COG0031: Cysteine synthase [Escherichia coli E24377A], gi\|157155432\|r...	362.0	[0..1]	[323..1]
gi\|24052837, gi\|... - gi\|24113759\|ref\|NP_708269.1\| cysteine synthase A [Shigella flexneri 2a str. 301], gi\|24052837\|gb\|AAN... gi\|110615903, gi... - gi\|110806355\|ref\|YP_689875.1\| cysteine synthase A [Shigella flexneri 5 str. 8401], gi\|110615903\|gb\|A...	360.0	[0..1]	[323..1]
gi\|30063808, gi\|... - gi\|30063808\|ref\|NP_837979.1\| cysteine synthase A [Shigella flexneri 2a str. 2457T], gi\|30042063\|gb\|A... gi\|81246285, gi\|... - gi\|82544874\|ref\|YP_408821.1\| cysteine synthase A [Shigella boydii Sb227], gi\|81246285\|gb\|ABB66993.1\|...	359.0	[0..1]	[323..1]
gi\|29136579, gi\|... - gi\|29140954\|ref\|NP_804296.1\| cysteine synthase A [Salmonella enterica subsp. enterica serovar Typhi ... gi\|16761350 - gi\|16761350\|ref\|NP_456967.1\| cysteine synthase A [Salmonella enterica subsp. enterica serovar Typhi ... gi\|168231970, gi... - gi\|205333619\|gb\|EDZ20383.1\| cysteine synthase A [Salmonella enterica subsp. enterica serovar Kentuck... gi\|167991724, gi... - gi\|205329895\|gb\|EDZ16659.1\| cysteine synthase A [Salmonella enterica subsp. enterica serovar 4,[5],1... gi\|161362191, gi... - gi\|161612827\|ref\|YP_001586792.1\| cysteine synthase A [Salmonella enterica subsp. enterica serovar Pa... gi\|200388665, gi... - gi\|200388665\|ref\|ZP_03215277.1\| cysteine synthase A [Salmonella enterica subsp. enterica serovar Vir... gi\|238912845 - gi\|238912845\|ref\|ZP_04656682.1\| cysteine synthase A [Salmonella enterica subsp. enterica serovar Ten... gi\|197361617, gi... - gi\|197361617\|ref\|YP_002141253.1\| cysteine synthase A [Salmonella enterica subsp. enterica serovar Pa... gi\|197264097, gi... - gi\|197264097\|ref\|ZP_03164171.1\| cysteine synthase A [Salmonella enterica subsp. enterica serovar Sai... gi\|197215186, gi... - gi\|197251483\|ref\|YP_002147383.1\| cysteine synthase A [Salmonella enterica subsp. enterica serovar Ag... gi\|213622985 - gi\|213622985\|ref\|ZP_03375768.1\| cysteine synthase A [Salmonella enterica subsp. enterica serovar Typ... lcl\|NC_016856.1_... - [gene=cysK] [protein=cysteine synthase A] [protein_id=YP_005238513.1] [location=2594783..2595754] gi\|62128631, gi\|... - gi\|62180998\|ref\|YP_217415.1\| cysteine synthase A [Salmonella enterica subsp. enterica serovar Choler... gi\|213424290 - gi\|213424290\|ref\|ZP_03357122.1\| cysteine synthase A [Salmonella enterica subsp. enterica serovar Typ... gi\|56126940, gi\|... - gi\|56412683\|ref\|YP_149758.1\| cysteine synthase A [Salmonella enterica subsp. enterica serovar Paraty... gi\|213051552 - gi\|213051552\|ref\|ZP_03344430.1\| cysteine synthase A [Salmonella enterica subsp. enterica serovar Typ... CYSK_SALTY - Cysteine synthase A OS=Salmonella typhimurium GN=cysK PE=1 SV=2 gi\|204321250, gi... - gi\|204929531\|ref\|ZP_03220605.1\| cysteine synthase A [Salmonella enterica subsp. enterica serovar Jav... gi\|205345028, gi... - gi\|205345028\|gb\|EDZ31792.1\| cysteine synthase A [Salmonella enterica subsp. enterica serovar Weltevr... gi\|168466833, gi... - gi\|195630757\|gb\|EDX49349.1\| cysteine synthase A [Salmonella enterica subsp. enterica serovar Newport... gi\|205337663, gi... - gi\|205337663\|gb\|EDZ24427.1\| cysteine synthase A [Salmonella enterica subsp. enterica serovar Heidelb... gi\|197288338, gi... - gi\|197288338\|gb\|EDY27719.1\| cysteine synthase A [Salmonella enterica subsp. enterica serovar Schwarz... CYSK_SALTI - Cysteine synthase A OS=Salmonella typhi GN=cysK PE=3 SV=2 gi\|194711808, gi... - gi\|194736306\|ref\|YP_002115496.1\| cysteine synthase A [Salmonella enterica subsp. enterica serovar Sc... CYSK_SALTY - Cysteine synthase A OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=cysK PE=1 SV=... gi\|194472179, gi... - gi\|194472179\|ref\|ZP_03078163.1\| cysteine synthase A [Salmonella enterica subsp. enterica serovar Ken... gi\|194448459, gi... - gi\|194448459\|ref\|YP_002046494.1\| cysteine synthase A [Salmonella enterica subsp. enterica serovar He... CYSK_SALTI - Cysteine synthase A OS=Salmonella typhi GN=cysK PE=3 SV=2 gi\|194405363, gi... - gi\|194446700\|ref\|YP_002041690.1\| cysteine synthase A [Salmonella enterica subsp. enterica serovar Ne... CYSK_SALTY - Cysteine synthase A OS=Salmonella typhimurium GN=cysK PE=1 SV=2 gi\|224583037, gi... - gi\|224583037\|ref\|YP_002636835.1\| cysteine synthase A [Salmonella enterica subsp. enterica serovar Pa... gi\|214003199 - gi\|214003199\|ref\|ZP_03413934.1\| cysteine synthase A [Salmonella enterica subsp. enterica serovar Typ... gi\|213646055 - gi\|213646055\|ref\|ZP_03376108.1\| cysteine synthase A [Salmonella enterica subsp. enterica serovar Typ...	358.0	[0..1]	[323..1]
gi\|82777808, gi\|... - gi\|82777808\|ref\|YP_404157.1\| cysteine synthase A [Shigella dysenteriae Sd197], gi\|81241956\|gb\|ABB626...	357.0	[0..1]	[323..1]
gi\|26109196, gi\|... - gi\|26248790\|ref\|NP_754830.1\| cysteine synthase A [Escherichia coli CFT073], gi\|26109196\|gb\|AAN81398....	357.0	[0..1]	[323..1]
gi\|150956141, gi... - gi\|152971292\|ref\|YP_001336401.1\| cysteine synthase A [Klebsiella pneumoniae subsp. pneumoniae MGH 78... gi\|110180268 - gi\|110180268\|gb\|ABG54376.1\| cysteine synthase A [Klebsiella pneumoniae] gi\|238548204, gi... - gi\|238895886\|ref\|YP_002920622.1\| cysteine synthase A/O-acetylserine sulfhydrolase A [Klebsiella pneu...	357.0	[0..1]	[323..1]
gi\|145686 - gi\|145686\|gb\|AAA23654.1\| cysK protein	356.0	[0..1]	[323..1]
gi\|7188603 - gi\|7188603\|gb\|AAF37822.1\|AF192489_1 cysteine sulfhydrylase [Salmonella enterica subsp. enterica sero...	355.0	[0..1]	[323..1]

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Predicted Domain #1

Region A:
Residues: [1-323]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKIFEDNSL TIGHTPLVRL NRIGNGRILA KVESRNPSFS VKCRIGANMI WDAEKRGVLK  60
   61 PGVELVEPTS GNTGIALAYV AAARGYKLTL TMPETMSIER RKLLKALGAN LVLTEGAKGM 120
  121 KGAIQKAEEI VASNPEKYLL LQQFSNPANP EIHEKTTGPE IWEDTDGQVD VFIAGVGTGG 180
  181 TLTGVSRYIK GTKGKTDLIS VAVEPTDSPV IAQALAGEEI KPGPHKIQGI GAGFIPANLD 240
  241 LKLVDKVIGI TNEEAISTAR RLMEEEGILA GISSGAAVAA ALKLQEDESF TNKNIVVILP 300
  301 SSGERYLSTA LFADLFTEKE LQQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	97.522879
Match:	1fcjA
Description:	O-acetylserine sulfhydrylase (Cysteine synthase)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
cysteine synthase activity	5.18562032111987	bayes_pls_golite062009
catalytic activity	2.38994231321972	bayes_pls_golite062009
lyase activity	1.87743897464083	bayes_pls_golite062009
cystathionine beta-synthase activity	1.4517088142802	bayes_pls_golite062009
tryptophan synthase activity	1.04832999357666	bayes_pls_golite062009
carbon-oxygen lyase activity	0.923824749425553	bayes_pls_golite062009
threonine synthase activity	0.727838845253199	bayes_pls_golite062009
ammonia-lyase activity	0.476674617721478	bayes_pls_golite062009
L-threonine ammonia-lyase activity	0.37325071016009	bayes_pls_golite062009
carbon-nitrogen lyase activity	0.249761226675912	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: