YRC Public Data Repository - Protein Structure Prediction

Protein:	CODA_ECOLI
Organism:	Escherichia coli
Length:	427 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CODA_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|75238478, gi\|... - gi\|75238478\|ref\|ZP_00722472.1\| COG0402: Cytosine deaminase and related metal-dependent hydrolases [E... gi\|110342208, gi... - gi\|110640616\|ref\|YP_668344.1\| cytosine deaminase [Escherichia coli 536], gi\|110342208\|gb\|ABG68445.1\|...	273.0	[0..1]	[427..1]
gi\|218350533, gi... - gi\|218693801\|ref\|YP_002401468.1\| cytosine deaminase [Escherichia coli 55989], gi\|218350533\|emb\|CAU96... gi\|75231104, gi\|... - gi\|75231104\|ref\|ZP_00717526.1\| COG0402: Cytosine deaminase and related metal-dependent hydrolases [E... gi\|157078191, gi... - gi\|75189411\|ref\|ZP_00702678.1\| COG0402: Cytosine deaminase and related metal-dependent hydrolases [E...	273.0	[0..1]	[427..1]
gi\|217320683, gi... - gi\|217324462\|ref\|ZP_03440546.1\| cytosine deaminase [Escherichia coli O157:H7 str. TW14588], gi\|21732... gi\|208815432, gi... - gi\|208815432\|ref\|ZP_03256611.1\| cytosine deaminase [Escherichia coli O157:H7 str. EC4045], gi\|208732... gi\|208728115, gi... - gi\|208808314\|ref\|ZP_03250651.1\| cytosine deaminase [Escherichia coli O157:H7 str. EC4206], gi\|208728... gi\|209399439, gi... - gi\|209399439\|ref\|YP_002268976.1\| cytosine deaminase [Escherichia coli O157:H7 str. EC4115], gi\|20916... gi\|208823242, gi... - gi\|208823242\|ref\|ZP_03263560.1\| cytosine deaminase [Escherichia coli O157:H7 str. EC4042], gi\|208737... gi\|189371686, gi... - gi\|189371686\|gb\|EDU90102.1\| cytosine deaminase [Escherichia coli O157:H7 str. EC869], gi\|168788641\|r... gi\|188999896, gi... - gi\|188999896\|gb\|EDU68882.1\| cytosine deaminase [Escherichia coli O157:H7 str. EC4076], gi\|168782720\|... gi\|195937838 - gi\|195937838\|ref\|ZP_03083220.1\| cytosine deaminase [Escherichia coli O157:H7 str. EC4024] gi\|168799713, gi... - gi\|189377869\|gb\|EDU96285.1\| cytosine deaminase [Escherichia coli O157:H7 str. EC508], gi\|168799713\|r... gi\|168762009, gi... - gi\|189367677\|gb\|EDU86093.1\| cytosine deaminase [Escherichia coli O157:H7 str. EC4501], gi\|168762009\|... gi\|168755922, gi... - gi\|189356932\|gb\|EDU75351.1\| cytosine deaminase [Escherichia coli O157:H7 str. EC4401], gi\|168755922\|... gi\|15829644, gi\|... - gi\|15829644\|ref\|NP_308417.1\| cytosine deaminase [Escherichia coli O157:H7 str. Sakai], gi\|13359847\|d... gi\|187769074, gi... - gi\|187769074\|gb\|EDU32918.1\| cytosine deaminase [Escherichia coli O157:H7 str. EC4196], gi\|168775331\|... gi\|168769724, gi... - gi\|189361348\|gb\|EDU79767.1\| cytosine deaminase [Escherichia coli O157:H7 str. EC4486], gi\|168769724\|... gi\|25389804, gi\|... - pir\|\|B85528 cytosine deaminase [imported] - Escherichia coli (strain O157:H7, substrain EDL933), pi... gi\|15800066, gi\|... - gi\|15800066\|ref\|NP_286078.1\| cytosine deaminase [Escherichia coli O157:H7 EDL933], gi\|12513168\|gb\|AA... gi\|188016511, gi... - gi\|188016511\|gb\|EDU54633.1\| cytosine deaminase [Escherichia coli O157:H7 str. EC4113], gi\|168749219\|... gi\|15829644, gi\|... - gi\|15829644\|ref\|NP_308417.1\| cytosine deaminase [Escherichia coli O157:H7], gi\|13359847\|dbj\|BAB33813... gi\|254791516, gi... - gi\|254791516\|ref\|YP_003076353.1\| cytosine deaminase [Escherichia coli O157:H7 str. TW14359], gi\|2545...	273.0	[0..1]	[427..1]
gi\|75257636, gi\|... - gi\|75257636\|ref\|ZP_00729127.1\| COG0402: Cytosine deaminase and related metal-dependent hydrolases [E... gi\|75194561, gi\|... - gi\|75194561\|ref\|ZP_00704631.1\| COG0402: Cytosine deaminase and related metal-dependent hydrolases [E... gi\|218359672, gi... - gi\|218552904\|ref\|YP_002385817.1\| cytosine deaminase [Escherichia coli IAI1], gi\|218359672\|emb\|CAQ972... gi\|209910812, gi... - gi\|209917553\|ref\|YP_002291637.1\| cytosine deaminase [Escherichia coli SE11], gi\|209910812\|dbj\|BAG758... gi\|215263516, gi... - gi\|215485444\|ref\|YP_002327875.1\| cytosine deaminase [Escherichia coli O127:H6 str. E2348/69], gi\|215...	273.0	[0..1]	[427..1]
gi\|1246363 - gi\|1246363\|gb\|AAA93512.1\| cytosine deaminase:uracil phosphoribosyltransferase fusion protein [Clonin... gi\|1246357 - gi\|1246357\|gb\|AAA93508.1\| cytosine deaminase:uracil phosphoribosyltransferase fusion protein [Clonin... gi\|1246360 - gi\|1246360\|gb\|AAA93510.1\| cytosine deaminase:uracil phosphoribosyltransferase fusion protein [Clonin... gi\|1246354 - gi\|1246354\|gb\|AAA93506.1\| cytosine deaminase:uracil phosphoribosyltransferase fusion protein [Clonin...	273.0	[0..2]	[427..3]
gi\|55669647, gi\|... - gi\|55669650\|pdb\|1RAK\|A Chain A, Bacterial Cytosine Deaminase D314s Mutant Bound To 5-Fluoro- 4-(S)-H...	272.0	[0..1]	[427..4]

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Predicted Domain #1

Region A:
Residues: [1-427]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNNALQTII NARLPGEEGL WQIHLQDGKI SAIDAQSGVM PITENSLDAE QGLVIPPFVE  60
   61 PHIHLDTTQT AGQPNWNQSG TLFEGIERWA ERKALLTHDD VKQRAWQTLK WQIANGIQHV 120
  121 RTHVDVSDAT LTALKAMLEV KQEVAPWIDL QIVAFPQEGI LSYPNGEALL EEALRLGADV 180
  181 VGAIPHFEFT REYGVESLHK TFALAQKYDR LIDVHCDEID DEQSRFVETV AALAHHEGMG 240
  241 ARVTASHTTA MHSYNGAYTS RLFRLLKMSG INFVANPLVN IHLQGRFDTY PKRRGITRVK 300
  301 EMLESGINVC FGHDDVFDPW YPLGTANMLQ VLHMGLHVCQ LMGYGQINDG LNLITHHSAR 360
  361 TLNLQDYGIA AGNSANLIIL PAENGFDALR RQVPVRYSVR GGKVIASTQP AQTTVYLEQP 420
  421 EAIDYKR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	73.0
Match:	1r9zA
Description:	Bacterial cytosine deaminase D314S mutant.
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
deaminase activity	1.79186203771221	bayes_pls_golite062009
catalytic activity	1.70199291046899	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	1.60895003474033	bayes_pls_golite062009
hydrolase activity	1.30610496460396	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	0.787370269329878	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	0.573107361273483	bayes_pls_golite062009
dihydroorotase activity	0.203044795244555	bayes_pls_golite062009
guanine deaminase activity	0.134430884998957	bayes_pls_golite062009
dihydropyrimidinase activity	0.101722148781441	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: