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View Structure Prediction Details

Protein: DNAK_ECOLI
Organism: Escherichia coli
Length: 638 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DNAK_ECOLI.

Description E-value Query
Range		 Subject
Range
DNAK_XANP2 - Chaperone protein DnaK OS=Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2) GN=dnaK PE=3 SV=1
 712.0 [0..1] [638..1]
DNAK_BARBK - Chaperone protein DnaK OS=Bartonella bacilliformis (strain ATCC 35685 / KC583) GN=dnaK PE=3 SV=1
 711.0 [0..1] [638..1]
DNAK_BARHE - Chaperone protein DnaK OS=Bartonella henselae GN=dnaK PE=2 SV=1
DNAK_BARHE - Chaperone protein DnaK OS=Bartonella henselae (strain ATCC 49882 / DSM 28221 / Houston 1) GN=dnaK PE...
 711.0 [0..1] [638..1]
DNAK_CHESB - Chaperone protein DnaK OS=Chelativorans sp. (strain BNC1) GN=dnaK PE=3 SV=1
 710.0 [0..1] [637..1]
DNAK_GEOMG - Chaperone protein DnaK OS=Geobacter metallireducens (strain GS-15 / ATCC 53774 / DSM 7210) GN=dnaK P...
 709.0 [0..1] [638..1]
DNAK_BARQU - Chaperone protein DnaK OS=Bartonella quintana GN=dnaK PE=2 SV=1
DNAK_BARQU - Chaperone protein DnaK OS=Bartonella quintana (strain Toulouse) GN=dnaK PE=3 SV=1
 708.0 [0..1] [638..1]
gi|144898439 - gi|144898439|emb|CAM75303.1| Chaperone protein DnaK [Magnetospirillum gryphiswaldense MSR-1]
gi|38422328 - gi|38422328|emb|CAE45330.1| unnamed protein product [Magnetospirillum gryphiswaldense]
 708.0 [0..1] [638..52]
gi|254690260 - gi|254690260|ref|ZP_05153514.1| molecular chaperone DnaK [Brucella abortus bv. 6 str. 870]
gi|254694747 - gi|254694747|ref|ZP_05156575.1| molecular chaperone DnaK [Brucella abortus bv. 3 str. Tulya]
DNAK_BRUAB - Chaperone protein DnaK OS=Brucella abortus biovar 1 (strain 9-941) GN=dnaK PE=3 SV=1
gi|82700876 - gi|82700876|ref|YP_415450.1| molecular chaperone DnaK [Brucella melitensis biovar Abortus 2308]
gi|225641917, gi... - gi|225853552|ref|YP_002733785.1| chaperone protein DnaK [Brucella melitensis ATCC 23457], gi|2256419...
DNAK_BRUO2 - Chaperone protein DnaK OS=Brucella ovis (strain ATCC 25840 / 63/290 / NCTC 10512) GN=dnaK PE=2 SV=2
gi|254709102 - gi|254709102|ref|ZP_05170913.1| molecular chaperone DnaK [Brucella pinnipedialis B2/94]
DNAK_BRUAB - Chaperone protein dnaK OS=Brucella abortus GN=dnaK PE=2 SV=1
gi|254713473 - gi|254713473|ref|ZP_05175284.1| molecular chaperone DnaK [Brucella ceti M644/93/1]
gi|254696376 - gi|254696376|ref|ZP_05158204.1| molecular chaperone DnaK [Brucella abortus bv. 2 str. 86/8/59]
gi|254707356 - gi|254707356|ref|ZP_05169184.1| molecular chaperone DnaK [Brucella pinnipedialis M163/99/10]
gi|254731290 - gi|254731290|ref|ZP_05189868.1| molecular chaperone DnaK [Brucella abortus bv. 4 str. 292]
gi|254716172 - gi|254716172|ref|ZP_05177983.1| molecular chaperone DnaK [Brucella ceti M13/05/1]
gi|254718168 - gi|254718168|ref|ZP_05179979.1| molecular chaperone DnaK [Brucella sp. 83/13]
gi|163674864, gi... - gi|163844141|ref|YP_001628546.1| molecular chaperone DnaK [Brucella suis ATCC 23445], gi|163674864|g...
gi|189025179, gi... - gi|189025179|ref|YP_001935947.1| Heat shock protein Hsp70 [Brucella abortus S19], gi|189020751|gb|AC...
 706.0 [0..1] [638..1]
DNAK_GEOSL - Chaperone protein DnaK OS=Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA) GN=dnaK PE=...
DNAK_GEOSL - Chaperone protein DnaK OS=Geobacter sulfurreducens GN=dnaK PE=2 SV=1
 705.0 [0..1] [638..1]
gi|161620037, gi... - gi|161620037|ref|YP_001593924.1| molecular chaperone DnaK [Brucella canis ATCC 23365], gi|161336848|...
gi|254705129 - gi|254705129|ref|ZP_05166957.1| molecular chaperone DnaK [Brucella suis bv. 3 str. 686]
DNAK_BRUSU - Chaperone protein DnaK OS=Brucella suis biovar 1 (strain 1330) GN=dnaK PE=3 SV=1
DNAK_BRUSU - Chaperone protein dnaK OS=Brucella suis GN=dnaK PE=2 SV=1
 705.0 [0..1] [638..1]

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Predicted Domain #1
Region A:
Residues: [1-384] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGKIIGIDLG TTNSCVAIMD GTTPRVLENA EGDRTTPSII AYTQDGETLV GQPAKRQAVT  60
   61 NPQNTLFAIK RLIGRRFQDE EVQRDVSIMP FKIIAADNGD AWVEVKGQKM APPQISAEVL 120
  121 KKMKKTAEDY LGEPVTEAVI TVPAYFNDAQ RQATKDAGRI AGLEVKRIIN EPTAAALAYG 180
  181 LDKGTGNRTI AVYDLGGGTF DISIIEIDEV DGEKTFEVLA TNGDTHLGGE DFDSRLINYL 240
  241 VEEFKKDQGI DLRNDPLAMQ RLKEAAEKAK IELSSAQQTD VNLPYITADA TGPKHMNIKV 300
  301 TRAKLESLVE DLVNRSIEPL KVALQDAGLS VSDIDDVILV GGQTRMPMVQ KKVAEFFGKE 360
  361 PRKDVNPDEA VAIGAAVQGG VLTG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 126.0
Match: 1dkgD
Description: Heat shock protein 70kDa, ATPase fragment
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
unfolded protein binding 7.97191512372019 bayes_pls_golite062009
structural molecule activity 3.59589495899762 bayes_pls_golite062009
structural constituent of cytoskeleton 2.46121037473545 bayes_pls_golite062009
carbohydrate kinase activity 2.33338276303563 bayes_pls_golite062009
cytoskeletal protein binding 2.20983242331685 bayes_pls_golite062009
binding 2.11855816699924 bayes_pls_golite062009
protein binding 2.00711904074672 bayes_pls_golite062009
hydrolase activity 1.88613511243568 bayes_pls_golite062009
hexokinase activity 1.70516840340504 bayes_pls_golite062009
transcription regulator activity 1.68670098354938 bayes_pls_golite062009
nucleic acid binding 1.43834016708999 bayes_pls_golite062009
peptidase activity 1.4127499531612 bayes_pls_golite062009
DNA binding 1.36804228074586 bayes_pls_golite062009
transporter activity 1.2883466875237 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.16749728168925 bayes_pls_golite062009
kinase activity 1.11102445353265 bayes_pls_golite062009
actin binding 1.03829083423378 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.953663805249074 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.900931843471417 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.898645342556399 bayes_pls_golite062009
pyrophosphatase activity 0.875671218597808 bayes_pls_golite062009
substrate-specific transporter activity 0.796517590178929 bayes_pls_golite062009
transcription factor activity 0.783439770973386 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.78242344952806 bayes_pls_golite062009
protein transporter activity 0.780308299678282 bayes_pls_golite062009
ATPase activity 0.687771333492666 bayes_pls_golite062009
myosin binding 0.607451856096 bayes_pls_golite062009
glucose binding 0.53527958884988 bayes_pls_golite062009
glucokinase activity 0.47468456642723 bayes_pls_golite062009
catalytic activity 0.296484721581333 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.186218331473028 bayes_pls_golite062009
chromatin binding 0.155140608043269 bayes_pls_golite062009
protease binding 0.121259015422625 bayes_pls_golite062009
chaperone binding 0.00111313452804307 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [385-638] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DVKDVLLLDV TPLSLGIETM GGVMTTLIAK NTTIPTKHSQ VFSTAEDNQS AVTIHVLQGE  60
   61 RKRAADNKSL GQFNLDGINP APRGMPQIEV TFDIDADGIL HVSAKDKNSG KEQKITIKAS 120
  121 SGLNEDEIQK MVRDAEANAE ADRKFEELVQ TRNQGDHLLH STRKQVEEAG DKLPADDKTA 180
  181 IESALTALET ALKGEDKAAI EAKMQELAQV SQKLMEIAQQ QHAQQQTAGA DASANNAKDD 240
  241 DVVDAEFEEV KDKK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 58.522879
Match: 1dkyA
Description: DnaK
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle