YRC Public Data Repository - Protein Structure Prediction

Protein:	KDSB_ECOLI
Organism:	Escherichia coli
Length:	248 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for KDSB_ECOLI.

Description	E-value	Query Range	Subject Range
KDSB_SHIDS - 3-deoxy-manno-octulosonate cytidylyltransferase OS=Shigella dysenteriae serotype 1 (strain Sd197) GN...	223.0	[0..1]	[248..1]
gi\|189376445, gi... - gi\|189376445\|gb\|EDU94861.1\| 3-deoxy-D-manno-octulosonate cytidylyltransferase [Escherichia coli O157... gi\|195940075 - gi\|195940075\|ref\|ZP_03085457.1\| 3-deoxy-manno-octulosonate cytidylyltransferase [Escherichia coli O1... gi\|208728652, gi... - gi\|208808851\|ref\|ZP_03251188.1\| 3-deoxy-D-manno-octulosonate cytidylyltransferase [Escherichia coli ... gi\|208815377, gi... - gi\|208815377\|ref\|ZP_03256556.1\| 3-deoxy-D-manno-octulosonate cytidylyltransferase [Escherichia coli ... gi\|189361176, gi... - gi\|189361176\|gb\|EDU79595.1\| 3-deoxy-D-manno-octulosonate cytidylyltransferase [Escherichia coli O157... gi\|168776229, gi... - gi\|187768346\|gb\|EDU32190.1\| 3-deoxy-D-manno-octulosonate cytidylyltransferase [Escherichia coli O157... gi\|188998658, gi... - gi\|188998658\|gb\|EDU67644.1\| 3-deoxy-D-manno-octulosonate cytidylyltransferase [Escherichia coli O157... gi\|168787347, gi... - gi\|189372629\|gb\|EDU91045.1\| 3-deoxy-D-manno-octulosonate cytidylyltransferase [Escherichia coli O157... gi\|254792117, gi... - gi\|254792117\|ref\|YP_003076954.1\| 3-deoxy-manno-octulosonate cytidylyltransferase [Escherichia coli O... gi\|188014719, gi... - gi\|188014719\|gb\|EDU52841.1\| 3-deoxy-D-manno-octulosonate cytidylyltransferase [Escherichia coli O157... gi\|168757010, gi... - gi\|189355899\|gb\|EDU74318.1\| 3-deoxy-D-manno-octulosonate cytidylyltransferase [Escherichia coli O157... gi\|168762945, gi... - gi\|189366823\|gb\|EDU85239.1\| 3-deoxy-D-manno-octulosonate cytidylyltransferase [Escherichia coli O157... gi\|15830255, gi\|... - gi\|15830255\|ref\|NP_309028.1\| 3-deoxy-manno-octulosonate cytidylyltransferase [Escherichia coli O157:... KDSB_ECO57 - 3-deoxy-manno-octulosonate cytidylyltransferase OS=Escherichia coli O157:H7 GN=kdsB PE=3 SV=3 gi\|209774808, gi... - pir\|\|G85617 hypothetical protein kdsB [imported] - Escherichia coli (strain O157:H7, substrain EDL9... gi\|12514087, gi\|... - gi\|15800779\|ref\|NP_286793.1\| 3-deoxy-manno-octulosonate cytidylyltransferase [Escherichia coli O157:... gi\|208822571, gi... - gi\|208822571\|ref\|ZP_03262890.1\| 3-deoxy-D-manno-octulosonate cytidylyltransferase [Escherichia coli ... KDSB_ECO5E - 3-deoxy-manno-octulosonate cytidylyltransferase OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) G... gi\|217325627, gi... - gi\|217325627\|ref\|ZP_03441711.1\| 3-deoxy-D-manno-octulosonate cytidylyltransferase [Escherichia coli ...	223.0	[0..1]	[248..1]
gi\|75234399, gi\|... - gi\|75234399\|ref\|ZP_00718760.1\| COG1212: CMP-2-keto-3-deoxyoctulosonic acid synthetase [Escherichia c... KDSB_ECO24 - 3-deoxy-manno-octulosonate cytidylyltransferase OS=Escherichia coli O139:H28 (strain E24377A / ETEC)... KDSB_ECO55 - 3-deoxy-manno-octulosonate cytidylyltransferase OS=Escherichia coli (strain 55989 / EAEC) GN=kdsB PE... KDSB_ECOSE - 3-deoxy-manno-octulosonate cytidylyltransferase OS=Escherichia coli (strain SE11) GN=kdsB PE=3 SV=1 KDSB_ECO8A - 3-deoxy-manno-octulosonate cytidylyltransferase OS=Escherichia coli O8 (strain IAI1) GN=kdsB PE=3 SV...	222.0	[0..1]	[248..1]
gi\|115512260, gi... - gi\|117623136\|ref\|YP_852049.1\| 3-deoxy-manno-octulosonate cytidylyltransferase [Escherichia coli APEC...	222.0	[0..1]	[248..1]
gi\|194420217, gi... - gi\|83571213\|ref\|ZP_00922654.1\| COG1212: CMP-2-keto-3-deoxyoctulosonic acid synthetase [Shigella dyse...	222.0	[0..1]	[248..1]
gi\|75240993, gi\|... - gi\|75240993\|ref\|ZP_00724882.1\| COG1212: CMP-2-keto-3-deoxyoctulosonic acid synthetase [Escherichia c... gi\|218557823, gi... - gi\|218557823\|ref\|YP_002390736.1\| 3-deoxy-manno-octulosonate cytidylyltransferase [Escherichia coli S... gi\|218688761, gi... - gi\|218688761\|ref\|YP_002396973.1\| 3-deoxy-manno-octulosonate cytidylyltransferase [Escherichia coli E... gi\|91210019, gi\|... - gi\|91210019\|ref\|YP_540005.1\| 3-deoxy-manno-octulosonate cytidylyltransferase [Escherichia coli UTI89... gi\|226898304, gi... - gi\|237707094\|ref\|ZP_04537575.1\| 3-deoxy-manno-octulosonate cytidylyltransferase [Escherichia sp. 3_2... gi\|110342707, gi... - gi\|110641115\|ref\|YP_668845.1\| 3-deoxy-manno-octulosonate cytidylyltransferase [Escherichia coli 536]...	221.0	[0..1]	[248..1]
gi\|192927743, gi... - gi\|75257366\|ref\|ZP_00728882.1\| COG1212: CMP-2-keto-3-deoxyoctulosonic acid synthetase [Escherichia c... gi\|194428392, gi... - gi\|75210392\|ref\|ZP_00710548.1\| COG1212: CMP-2-keto-3-deoxyoctulosonic acid synthetase [Escherichia c...	221.0	[0..1]	[248..1]
KDSB_VIBFM - 3-deoxy-manno-octulosonate cytidylyltransferase OS=Vibrio fischeri (strain MJ11) GN=kdsB PE=3 SV=1 KDSB_VIBF1 - 3-deoxy-manno-octulosonate cytidylyltransferase OS=Vibrio fischeri (strain ATCC 700601 / ES114) GN=k...	221.0	[0..1]	[247..1]
gi\|227884117, gi... - gi\|227884117\|ref\|ZP_04001922.1\| 3-deoxy-manno-octulosonate cytidylyltransferase [Escherichia coli 83... KDSB_ECOL6 - 3-deoxy-manno-octulosonate cytidylyltransferase OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 7009... KDSB_ECOL6 - 3-deoxy-manno-octulosonate cytidylyltransferase OS=Escherichia coli O6 GN=kdsB PE=3 SV=3	221.0	[0..1]	[248..1]
gi\|190902983, gi... - gi\|75229876\|ref\|ZP_00716399.1\| COG1212: CMP-2-keto-3-deoxyoctulosonic acid synthetase [Escherichia c...	220.0	[0..1]	[248..1]

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Predicted Domain #1

Region A:
Residues: [1-248]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFVVIIPAR YASTRLPGKP LVDINGKPMI VHVLERARES GAERIIVATD HEDVARAVEA  60
   61 AGGEVCMTRA DHQSGTERLA EVVEKCAFSD DTVIVNVQGD EPMIPATIIR QVADNLAQRQ 120
  121 VGMATLAVPI HNAEEAFNPN AVKVVLDAEG YALYFSRATI PWDRDRFAEG LETVGDNFLR 180
  181 HLGIYGYRAG FIRRYVNWQP SPLEHIEMLE QLRVLWYGEK IHVAVAQEVP GTGVDTPEDL 240
  241 ERVRAEMR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	58.30103
Match:	1vh1A
Description:	Crystal structure of CMP-KDO synthetase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
polypeptide N-acetylgalactosaminyltransferase activity	2.87534754775824	bayes_pls_golite062009
3-deoxy-manno-octulosonate cytidylyltransferase activity	2.75368830096228	bayes_pls_golite062009
catalytic activity	2.25720704697246	bayes_pls_golite062009
transferase activity, transferring hexosyl groups	2.04393180556087	bayes_pls_golite062009
transferase activity	1.67251862595728	bayes_pls_golite062009
UDP-glycosyltransferase activity	1.51711005399931	bayes_pls_golite062009
cytidylyltransferase activity	1.30540294475078	bayes_pls_golite062009
transferase activity, transferring glycosyl groups	1.21894113759929	bayes_pls_golite062009
UDP-N-acetylglucosamine diphosphorylase activity	0.696745721981411	bayes_pls_golite062009
nucleotidyltransferase activity	0.67147527259372	bayes_pls_golite062009
uridylyltransferase activity	0.54930147038803	bayes_pls_golite062009
acetylgalactosaminyltransferase activity	0.48277064848483	bayes_pls_golite062009
mannose-phosphate guanylyltransferase activity	0.38929738612511	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.280335197569099	bayes_pls_golite062009
galactosyltransferase activity	0.21201767008409	bayes_pls_golite062009
glucose-1-phosphate thymidylyltransferase activity	0.204810937394121	bayes_pls_golite062009
guanylyltransferase activity	0.14847697203788	bayes_pls_golite062009
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity	0.00302319544700058	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: