YRC Public Data Repository - Protein Structure Prediction

Protein:	PPK_ECOLI
Organism:	Escherichia coli
Length:	688 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PPK_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|17132726, gi\|... - gi\|17231085\|ref\|NP_487633.1\| polyphosphate kinase [Nostoc sp. PCC 7120], gi\|17132726\|dbj\|BAB75292.1\|... gi\|25345242 - pir\|\|AB2255 polyphosphate kinase [imported] - Nostoc sp. (strain PCC 7120)	897.0	[0..1]	[683..13]
gi\|75909372, gi\|... - gi\|75909372\|ref\|YP_323668.1\| polyphosphate kinase [Anabaena variabilis ATCC 29413], gi\|75703097\|gb\|A...	891.0	[0..1]	[683..13]
gi\|74056598, gi\|... - gi\|74317103\|ref\|YP_314843.1\| polyphosphate kinase [Thiobacillus denitrificans ATCC 25259], gi\|740565...	890.0	[0..1]	[681..3]
gi\|86558072, gi\|... - gi\|86609530\|ref\|YP_478292.1\| polyphosphate kinase [Synechococcus sp. JA-2-3B'a(2-13)], gi\|86558072\|g... gi\|86609530 - gi\|86609530\|ref\|YP_478292.1\| polyphosphate kinase [Cyanobacteria bacterium Yellowstone B-Prime]	890.0	[0..4]	[684..43]
gi\|86607098, gi\|... - gi\|86607098\|ref\|YP_475861.1\| polyphosphate kinase [Synechococcus sp. JA-3-3Ab], gi\|86555640\|gb\|ABD00... gi\|86607098 - gi\|86607098\|ref\|YP_475861.1\| polyphosphate kinase [Cyanobacteria bacterium Yellowstone A-Prime]	886.0	[0..4]	[684..2]
PPK_SYNY3 - Polyphosphate kinase OS=Synechocystis sp. (strain ATCC 27184 / PCC 6803 / N-1) GN=ppk PE=3 SV=1 PPK_SYNY3 - Polyphosphate kinase OS=Synechocystis sp. (strain PCC 6803 / Kazusa) GN=ppk PE=3 SV=1 gi\|7469833 - pir\|\|S76968 hypothetical protein - Synechocystis sp. (strain PCC 6803)	885.0	[0..2]	[688..14]
gi\|186685803, gi... - gi\|53688188\|ref\|ZP_00109608.2\| COG0855: Polyphosphate kinase [Nostoc punctiforme PCC 73102], gi\|1866...	884.0	[0..1]	[683..13]
gi\|67920515, gi\|... - gi\|67920515\|ref\|ZP_00514035.1\| Polyphosphate kinase [Crocosphaera watsonii WH 8501], gi\|67857999\|gb\|...	884.0	[0..1]	[683..13]
PPK_MYCGI - Polyphosphate kinase OS=Mycobacterium gilvum (strain PYR-GCK) GN=ppk PE=3 SV=1	881.0	[0..3]	[680..48]
gi\|45521530, gi\|... - gi\|91774488\|ref\|YP_544244.1\| polyphosphate kinase [Methylobacillus flagellatus KT], gi\|91708475\|gb\|A...	879.0	[0..4]	[688..8]

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Predicted Domain #1

Region A:
Residues: [1-688]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGQEKLYIEK ELSWLSFNER VLQEAADKSN PLIERMRFLG IYSNNLDEFY KVRFAELKRR  60
   61 IIISEEQGSN SHSRHLLGKI QSRVLKADQE FDGLYNELLL EMARNQIFLI NERQLSVNQQ 120
  121 NWLRHYFKQY LRQHITPILI NPDTDLVQFL KDDYTYLAVE IIRGDTIRYA LLEIPSDKVP 180
  181 RFVNLPPEAP RRRKPMILLD NILRYCLDDI FKGFFDYDAL NAYSMKMTRD AEYDLVHEME 240
  241 ASLMELMSSS LKQRLTAEPV RFVYQRDMPN ALVEVLREKL TISRYDSIVP GGRYHNFKDF 300
  301 INFPNVGKAN LVNKPLPRLR HIWFDKAQFR NGFDAIRERD VLLYYPYHTF EHVLELLRQA 360
  361 SFDPSVLAIK INIYRVAKDS RIIDSMIHAA HNGKKVTVVV ELQARFDEEA NIHWAKRLTE 420
  421 AGVHVIFSAP GLKIHAKLFL ISRKENGEVV RYAHIGTGNF NEKTARLYTD YSLLTADARI 480
  481 TNEVRRVFNF IENPYRPVTF DYLMVSPQNS RRLLYEMVDR EIANAQQGLP SGITLKLNNL 540
  541 VDKGLVDRLY AASSSGVPVN LLVRGMCSLI PNLEGISDNI RAISIVDRYL EHDRVYIFEN 600
  601 GGDKKVYLSS ADWMTRNIDY RIEVATPLLD PRLKQRVLDI IDILFSDTVK ARYIDKELSN 660
  661 RYVPRGNRRK VRAQLAIYDY IKSLEQPE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1000.0
Match:	1xdoA
Description:	Crystal Structure of Escherichia coli Polyphosphate Kinase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
polyphosphate kinase activity	13.7847593568932	bayes_pls_golite062009
phosphotransferase activity, phosphate group as acceptor	4.58273206368885	bayes_pls_golite062009
kinase activity	2.73303197279191	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	2.40455487067749	bayes_pls_golite062009
transferase activity	1.58515858118724	bayes_pls_golite062009
catalytic activity	1.29236214516383	bayes_pls_golite062009
binding	0.86210568043471	bayes_pls_golite062009
phosphoric ester hydrolase activity	0.62416665753063	bayes_pls_golite062009
protein binding	0.361096900521699	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: