YRC Public Data Repository - Protein Structure Prediction

Protein:	EFTS_ECOLI
Organism:	Escherichia coli
Length:	283 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for EFTS_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|62178787, gi\|... - gi\|62178787\|ref\|YP_215204.1\| elongation factor Ts [Salmonella enterica subsp. enterica serovar Chole... gi\|161361952, gi... - gi\|161612588\|ref\|YP_001586553.1\| elongation factor Ts [Salmonella enterica subsp. enterica serovar P...	358.0	[0..1]	[283..25]
EFTS_PHOLL - Elongation factor Ts OS=Photorhabdus luminescens subsp. laumondii GN=tsf PE=3 SV=1 EFTS_PHOLL - Elongation factor Ts OS=Photorhabdus luminescens subsp. laumondii (strain DSM 15139 / CIP 105565 / T...	355.0	[0..1]	[281..1]
EFTS_ACTSZ - Elongation factor Ts OS=Actinobacillus succinogenes (strain ATCC 55618 / 130Z) GN=tsf PE=3 SV=1	353.0	[0..1]	[283..1]
EFTS_SODGM - Elongation factor Ts OS=Sodalis glossinidius (strain morsitans) GN=tsf PE=3 SV=1	352.0	[0..1]	[282..1]
EFTS_HISS2 - Elongation factor Ts OS=Histophilus somni (strain 2336) GN=tsf PE=3 SV=1 EFTS_HAES1 - Elongation factor Ts OS=Haemophilus somnus (strain 129Pt) GN=tsf PE=3 SV=1	352.0	[0..1]	[283..1]
gi\|194433429, gi... - gi\|83569752\|ref\|ZP_00921202.1\| COG0264: Translation elongation factor Ts [Shigella dysenteriae 1012]...	351.0	[0..1]	[283..1]
EFTS_SALTI - Elongation factor Ts OS=Salmonella typhi GN=tsf PE=3 SV=1 gi\|205331292, gi... - gi\|205331292\|gb\|EDZ18056.1\| translation elongation factor Ts [Salmonella enterica subsp. enterica se... gi\|205322173, gi... - gi\|205322173\|gb\|EDZ10012.1\| translation elongation factor Ts [Salmonella enterica subsp. enterica se... gi\|168234995, gi... - gi\|197291700\|gb\|EDY31050.1\| translation elongation factor Ts [Salmonella enterica subsp. enterica se... gi\|168230524, gi... - gi\|205334922\|gb\|EDZ21686.1\| translation elongation factor Ts [Salmonella enterica subsp. enterica se... EFTS_SALCH - Elongation factor Ts OS=Salmonella choleraesuis (strain SC-B67) GN=tsf PE=3 SV=2 lcl\|NC_016856.1_... - [gene=tsf] [protein=elongation factor Ts] [protein_id=YP_005235888.1] [location=255985..256836] EFTS_SALTI - Elongation factor Ts OS=Salmonella typhi GN=tsf PE=3 SV=1 gi\|213163138 - gi\|213163138\|ref\|ZP_03348848.1\| elongation factor Ts [Salmonella enterica subsp. enterica serovar Ty... EFTS_SALEP - Elongation factor Ts OS=Salmonella enteritidis PT4 (strain P125109) GN=tsf PE=3 SV=1 gi\|213425943 - gi\|213425943\|ref\|ZP_03358693.1\| elongation factor Ts [Salmonella enterica subsp. enterica serovar Ty... EFTS_SALTY - Elongation factor Ts OS=Salmonella typhimurium GN=tsf PE=3 SV=1 gi\|213416679 - gi\|213416679\|ref\|ZP_03349823.1\| elongation factor Ts [Salmonella enterica subsp. enterica serovar Ty... EFTS_SALCH - Elongation factor Ts OS=Salmonella choleraesuis GN=tsf PE=3 SV=2 EFTS_SALDC - Elongation factor Ts OS=Salmonella dublin (strain CT_02021853) GN=tsf PE=3 SV=1 gi\|197265873, gi... - gi\|197265873\|ref\|ZP_03165947.1\| translation elongation factor Ts [Salmonella enterica subsp. enteric... gi\|238911283 - gi\|238911283\|ref\|ZP_04655120.1\| elongation factor Ts [Salmonella enterica subsp. enterica serovar Te... gi\|204323482, gi... - gi\|204926817\|ref\|ZP_03218019.1\| translation elongation factor Ts [Salmonella enterica subsp. enteric... EFTS_SALTY - Elongation factor Ts OS=Salmonella typhimurium GN=tsf PE=3 SV=1 gi\|200388775, gi... - gi\|200388775\|ref\|ZP_03215387.1\| translation elongation factor Ts [Salmonella enterica subsp. enteric... EFTS_SALHS - Elongation factor Ts OS=Salmonella heidelberg (strain SL476) GN=tsf PE=3 SV=1 EFTS_SALCH - Elongation factor Ts OS=Salmonella choleraesuis GN=tsf PE=3 SV=2 EFTS_SALNS - Elongation factor Ts OS=Salmonella newport (strain SL254) GN=tsf PE=3 SV=1 EFTS_SALSV - Elongation factor Ts OS=Salmonella schwarzengrund (strain CVM19633) GN=tsf PE=3 SV=1 gi\|194455284, gi... - gi\|194468920\|ref\|ZP_03074904.1\| translation elongation factor Ts [Salmonella enterica subsp. enteric... gi\|168263916, gi... - gi\|205347489\|gb\|EDZ34120.1\| translation elongation factor Ts [Salmonella enterica subsp. enterica se... gi\|205336218, gi... - gi\|205336218\|gb\|EDZ22982.1\| translation elongation factor Ts [Salmonella enterica subsp. enterica se... gi\|168823245, gi... - gi\|205340482\|gb\|EDZ27246.1\| translation elongation factor Ts [Salmonella enterica subsp. enterica se... gi\|168464220, gi... - gi\|195632599\|gb\|EDX51053.1\| translation elongation factor Ts [Salmonella enterica subsp. enterica se... gi\|16759207 - gi\|16759207\|ref\|NP_454824.1\| elongation factor Ts [Salmonella enterica subsp. enterica serovar Typhi... EFTS_SALTY - Elongation factor Ts OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=tsf PE=3 SV=... gi\|29136381, gi\|... - gi\|29140757\|ref\|NP_804099.1\| elongation factor Ts [Salmonella enterica subsp. enterica serovar Typhi... gi\|214000840 - gi\|214000840\|ref\|ZP_03411575.1\| elongation factor Ts [Salmonella enterica subsp. enterica serovar Ty... gi\|213852165 - gi\|213852165\|ref\|ZP_03381697.1\| elongation factor Ts [Salmonella enterica subsp. enterica serovar Ty...	350.0	[0..1]	[283..1]
EFTS_SHIFL - (P0A6P4) Elongation factor Ts (EF-Ts) EFTS_ECOLI - (P0A6P1) Elongation factor Ts (EF-Ts) EFTS_ECO57 - (P0A6P3) Elongation factor Ts (EF-Ts) EFTS_ECOL6 - (P0A6P2) Elongation factor Ts (EF-Ts)	349.0	[0..2]	[283..1]
EFTS_ACTP2 - Elongation factor Ts OS=Actinobacillus pleuropneumoniae serotype 5b (strain L20) GN=tsf PE=3 SV=1 gi\|46143730 - gi\|46143730\|ref\|ZP_00134581.2\| COG0264: Translation elongation factor Ts [Actinobacillus pleuropneum... EFTS_ACTP7 - Elongation factor Ts OS=Actinobacillus pleuropneumoniae serotype 7 (strain AP76) GN=tsf PE=3 SV=1	349.0	[0..1]	[283..1]
EFTS_SALPA - Elongation factor Ts OS=Salmonella paratyphi A (strain ATCC 9150 / SARB42) GN=tsf PE=3 SV=1 EFTS_SALPA - Elongation factor Ts OS=Salmonella paratyphi A GN=tsf PE=3 SV=1 EFTS_SALPK - Elongation factor Ts OS=Salmonella paratyphi A (strain AKU_12601) GN=tsf PE=3 SV=1	349.0	[0..1]	[283..1]

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Predicted Domain #1

Region A:
Residues: [1-283]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAEITASLVK ELRERTGAGM MDCKKALTEA NGDIELAIEN MRKSGAIKAA KKAGNVAADG  60
   61 VIKTKIDGNY GIILEVNCQT DFVAKDAGFQ AFADKVLDAA VAGKITDVEV LKAQFEEERV 120
  121 ALVAKIGENI NIRRVAALEG DVLGSYQHGA RIGVLVAAKG ADEELVKHIA MHVAASKPEF 180
  181 IKPEDVSAEV VEKEYQVQLD IAMQSGKPKE IAEKMVEGRM KKFTGEVSLT GQPFVMEPSK 240
  241 TVGQLLKEHN AEVTGFIRFE VGEGIEKVET DFAAEVAAMS KQS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	96.39794
Match:	1efuB
Description:	Elongation factor Ts (EF-Ts), N-terminal domain; Elongation factor Ts (EF-Ts), dimerisation domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
translation elongation factor activity	7.45583793023677	bayes_pls_golite062009
translation regulator activity	3.96278094372195	bayes_pls_golite062009
translation factor activity, nucleic acid binding	3.9473033844258	bayes_pls_golite062009
nucleic acid binding	3.82932150818666	bayes_pls_golite062009
binding	3.42735689097363	bayes_pls_golite062009
transcription regulator activity	1.03112855383055	bayes_pls_golite062009
DNA binding	0.853492612495239	bayes_pls_golite062009
ubiquitin binding	0.83381750627184	bayes_pls_golite062009
small conjugating protein binding	0.643709242447801	bayes_pls_golite062009
protein binding	0.259532204752794	bayes_pls_golite062009
catalytic activity	0.25774924710417	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: