YRC Public Data Repository - Protein Structure Prediction

Protein:	SPEE_ECOLI
Organism:	Escherichia coli
Length:	288 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPEE_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|24111564, gi\|... - gi\|24111564\|ref\|NP_706074.1\| spermidine synthase [Shigella flexneri 2a str. 301], gi\|24050326\|gb\|AAN... SPEE_SHIFL - Polyamine aminopropyltransferase OS=Shigella flexneri GN=speE PE=3 SV=3 SPEE_SHIF8 - Polyamine aminopropyltransferase OS=Shigella flexneri serotype 5b (strain 8401) GN=speE PE=3 SV=1 gi\|30039928, gi\|... - gi\|30061686\|ref\|NP_835857.1\| spermidine synthase [Shigella flexneri 2a str. 2457T], gi\|30039928\|gb\|A...	253.0	[0..1]	[288..1]
gi\|226902189, gi... - gi\|237704277\|ref\|ZP_04534758.1\| spermidine synthase [Escherichia sp. 3_2_53FAA], gi\|226902189\|gb\|EEH... sp\|B7UIG9\|SPEE_ECO27 - Spermidine synthase OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=speE PE=3 SV=1 SPEE_ECOUT - Polyamine aminopropyltransferase OS=Escherichia coli (strain UTI89 / UPEC) GN=speE PE=3 SV=1 SPEE_ECOK1 - Polyamine aminopropyltransferase OS=Escherichia coli O1:K1 / APEC GN=speE PE=3 SV=1 SPEE_ECO27 - Polyamine aminopropyltransferase OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=speE PE=3 S... SPEE_ECO45 - Polyamine aminopropyltransferase OS=Escherichia coli O45:K1 (strain S88 / ExPEC) GN=speE PE=3 SV=1	253.0	[0..1]	[288..1]
gi\|194433428, gi... - gi\|83569702\|ref\|ZP_00921152.1\| COG0421: Spermidine synthase [Shigella dysenteriae 1012], gi\|19443342...	253.0	[0..1]	[288..1]
gi\|75240287, gi\|... - gi\|75240287\|ref\|ZP_00724234.1\| COG0421: Spermidine synthase [Escherichia coli F11], gi\|191172760\|ref... gi\|25287110, gi\|... - pir\|\|E85495 hypothetical protein speE [imported] - Escherichia coli (strain O157:H7, substrain EDL9... SPEE_ECOL6 - Polyamine aminopropyltransferase OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) GN=s... SPEE_ECOL6 - Spermidine synthase OS=Escherichia coli O6 GN=speE PE=3 SV=2 gi\|15799805, gi\|... - gi\|15799805\|ref\|NP_285817.1\| spermidine synthase [Escherichia coli O157:H7 EDL933], gi\|12512833\|gb\|A... SPEE_ECO57 - Polyamine aminopropyltransferase OS=Escherichia coli O157:H7 GN=speE PE=3 SV=2 SPEE_ECOL5 - Polyamine aminopropyltransferase OS=Escherichia coli O6:K15:H31 (strain 536 / UPEC) GN=speE PE=3 SV=... gi\|195938197 - gi\|195938197\|ref\|ZP_03083579.1\| spermidine synthase [Escherichia coli O157:H7 str. EC4024] gi\|227884968, gi... - gi\|227884968\|ref\|ZP_04002773.1\| spermidine synthase (putrescine aminopropyltransferase) [Escherichia... gi\|189376413, gi... - gi\|189376413\|gb\|EDU94829.1\| spermidine synthase [Escherichia coli O157:H7 str. EC508], gi\|168801456\|... gi\|254791256, gi... - gi\|254791256\|ref\|YP_003076093.1\| spermidine synthase (putrescine aminopropyltransferase) [Escherichi... gi\|208813176, gi... - gi\|208813176\|ref\|ZP_03254505.1\| spermidine synthase [Escherichia coli O157:H7 str. EC4045], gi\|20873... gi\|208807291, gi... - gi\|208807291\|ref\|ZP_03249628.1\| spermidine synthase [Escherichia coli O157:H7 str. EC4206], gi\|20872... SPEE_ECO5E - Polyamine aminopropyltransferase OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) GN=speE PE=3 SV=... gi\|208741568, gi... - gi\|208821445\|ref\|ZP_03261765.1\| spermidine synthase [Escherichia coli O157:H7 str. EC4042], gi\|20874... SPEE_ECO7I - Polyamine aminopropyltransferase OS=Escherichia coli O7:K1 (strain IAI39 / ExPEC) GN=speE PE=3 SV=1 gi\|15829379, gi\|... - gi\|15829379\|ref\|NP_308152.1\| spermidine synthase [Escherichia coli O157:H7 str. Sakai], gi\|13359581\|... gi\|217322391, gi... - gi\|217326170\|ref\|ZP_03442254.1\| spermidine synthase [Escherichia coli O157:H7 str. TW14588], gi\|2173... gi\|168752437, gi... - gi\|188013707\|gb\|EDU51829.1\| spermidine synthase [Escherichia coli O157:H7 str. EC4113], gi\|168752437... gi\|168764737, gi... - gi\|189365320\|gb\|EDU83736.1\| spermidine synthase [Escherichia coli O157:H7 str. EC4501], gi\|168764737... gi\|189356996, gi... - gi\|189356996\|gb\|EDU75415.1\| spermidine synthase [Escherichia coli O157:H7 str. EC4401], gi\|168755731... gi\|168776830, gi... - gi\|187767828\|gb\|EDU31672.1\| spermidine synthase [Escherichia coli O157:H7 str. EC4196], gi\|168776830... gi\|189360716, gi... - gi\|189360716\|gb\|EDU79135.1\| spermidine synthase [Escherichia coli O157:H7 str. EC4486], gi\|168770410... gi\|168789227, gi... - gi\|189371099\|gb\|EDU89515.1\| spermidine synthase [Escherichia coli O157:H7 str. EC869], gi\|168789227\|... gi\|168782010, gi... - gi\|189000433\|gb\|EDU69419.1\| spermidine synthase [Escherichia coli O157:H7 str. EC4076], gi\|168782010... SPEE_ECOLU - Polyamine aminopropyltransferase OS=Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC) GN=speE PE=...	253.0	[0..1]	[288..1]
SPEE_SHISS - Polyamine aminopropyltransferase OS=Shigella sonnei (strain Ss046) GN=speE PE=3 SV=1	253.0	[0..1]	[288..1]
SPEE_SHIB3 - Polyamine aminopropyltransferase OS=Shigella boydii serotype 18 (strain CDC 3083-94 / BS512) GN=speE...	252.0	[0..1]	[288..1]
SPEE_SHIBS - Polyamine aminopropyltransferase OS=Shigella boydii serotype 4 (strain Sb227) GN=speE PE=3 SV=1	250.0	[0..1]	[288..1]
SPEE_SHIDS - Polyamine aminopropyltransferase OS=Shigella dysenteriae serotype 1 (strain Sd197) GN=speE PE=3 SV=1	249.0	[0..1]	[288..1]
SPEE_PHOLL - Spermidine synthase OS=Photorhabdus luminescens subsp. laumondii GN=speE PE=3 SV=1 SPEE_PHOLL - Polyamine aminopropyltransferase OS=Photorhabdus luminescens subsp. laumondii (strain DSM 15139 / CI...	247.0	[0..1]	[283..1]
gi\|21957501, gi\|... - gi\|22124688\|ref\|NP_668111.1\| spermidine synthase [Yersinia pestis KIM], gi\|21957501\|gb\|AAM84362.1\|AE... gi\|45440134, gi\|... - gi\|45440134\|ref\|NP_991673.1\| spermidine synthase [Yersinia pestis biovar Microtus str. 91001], gi\|45...	244.0	[0..1]	[283..29]

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Predicted Domain #1

Region A:
Residues: [1-288]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAEKKQWHET LHDQFGQYFA VDNVLYHEKT DHQDLIIFEN AAFGRVMALD GVVQTTERDE  60
   61 FIYHEMMTHV PLLAHGHAKH VLIIGGGDGA MLREVTRHKN VESITMVEID AGVVSFCRQY 120
  121 LPNHNAGSYD DPRFKLVIDD GVNFVNQTSQ TFDVIISDCT DPIGPGESLF TSAFYEGCKR 180
  181 CLNPGGIFVA QNGVCFLQQE EAIDSHRKLS HYFSDVGFYQ AAIPTYYGGI MTFAWATDND 240
  241 ALRHLSTEII QARFLASGLK CRYYNPAIHT AAFALPQYLQ DALASQPS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	61.69897
Match:	2o05A
Description:	No description for 2o05A was found.

Predicted functions:

Term	Confidence	Notes
spermidine synthase activity	2.31131562815571	bayes_pls_golite062009
transferase activity	1.77671966857605	bayes_pls_golite062009
transcription regulator activity	1.61435611638306	bayes_pls_golite062009
DNA binding	1.53375495589674	bayes_pls_golite062009
nucleic acid binding	1.31440474302645	bayes_pls_golite062009
catalytic activity	1.25333584501255	bayes_pls_golite062009
binding	0.976078016260105	bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity	0.837368219068434	bayes_pls_golite062009
N-methyltransferase activity	0.69697643153076	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	0.644010137949015	bayes_pls_golite062009
methyltransferase activity	0.635463629299812	bayes_pls_golite062009
protein methyltransferase activity	0.57386401278889	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: