YRC Public Data Repository - Protein Structure Prediction

Protein:	PNCB_ECOLI
Organism:	Escherichia coli
Length:	400 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PNCB_ECOLI.

Description	E-value	Query Range	Subject Range
PNCB_SHIB3 - Nicotinate phosphoribosyltransferase OS=Shigella boydii serotype 18 (strain CDC 3083-94 / BS512) GN=...	472.0	[0..1]	[400..1]
gi\|110614488, gi... - gi\|110804940\|ref\|YP_688460.1\| nicotinate phosphoribosyltransferase [Shigella flexneri 5 str. 8401], ... gi\|170020667, gi... - gi\|170020667\|ref\|YP_001725621.1\| nicotinate phosphoribosyltransferase [Escherichia coli ATCC 8739], ... gi\|24051204, gi\|... - ref\|NP_706850.1\| nicotinate phosphoribosyltransferase [Shigella flexneri 2a str. 301], gb\|AAN42557.... gi\|124499410, gi... - gi\|124530123\|ref\|ZP_01700893.1\| nicotinate phosphoribosyltransferase [Escherichia coli B], gi\|124499...	471.0	[0..1]	[400..17]
gi\|194438710, gi... - gi\|83585874\|ref\|ZP_00924514.1\| COG1488: Nicotinic acid phosphoribosyltransferase [Escherichia coli 1... gi\|30062466, gi\|... - gi\|30062466\|ref\|NP_836637.1\| nicotinate phosphoribosyltransferase [Shigella flexneri 2a str. 2457T],... PNCB_ECO24 - Nicotinate phosphoribosyltransferase OS=Escherichia coli O139:H28 (strain E24377A / ETEC) GN=pncB PE... gi\|251784473, gi... - gi\|251784473\|ref\|YP_002998777.1\| hypothetical protein B21_00942 [Escherichia coli BL21], gi\|24237674... gi\|254161045, gi... - gi\|254161045\|ref\|YP_003044153.1\| nicotinate phosphoribosyltransferase [Escherichia coli B str. REL60... gi\|253977160, gi... - gi\|254287853\|ref\|YP_003053601.1\| nicotinate phosphoribosyltransferase [Escherichia coli BL21(DE3)], ... PNCB_ECO55 - Nicotinate phosphoribosyltransferase OS=Escherichia coli (strain 55989 / EAEC) GN=pncB PE=3 SV=1 PNCB_ECOSE - Nicotinate phosphoribosyltransferase OS=Escherichia coli (strain SE11) GN=pncB PE=3 SV=1 PNCB_ECO8A - Nicotinate phosphoribosyltransferase OS=Escherichia coli O8 (strain IAI1) GN=pncB PE=3 SV=1 gi\|190903000, gi... - gi\|75229863\|ref\|ZP_00716386.1\| COG1488: Nicotinic acid phosphoribosyltransferase [Escherichia coli B... PNCB_SHISS - Nicotinate phosphoribosyltransferase OS=Shigella sonnei (strain Ss046) GN=pncB PE=3 SV=1 PNCB_ECOHS - Nicotinate phosphoribosyltransferase OS=Escherichia coli O9:H4 (strain HS) GN=pncB PE=3 SV=1 PNCB_SHIFL - Nicotinate phosphoribosyltransferase OS=Shigella flexneri GN=pncB PE=3 SV=4 gi\|75214729, gi\|... - gi\|75214729\|ref\|ZP_00713234.1\| COG1488: Nicotinic acid phosphoribosyltransferase [Escherichia coli E... PNCB_SHIBS - Nicotinate phosphoribosyltransferase OS=Shigella boydii serotype 4 (strain Sb227) GN=pncB PE=3 SV=1 gi\|56383326, gi\|... - gi\|56479775\|ref\|NP_706850.2\| nicotinate phosphoribosyltransferase [Shigella flexneri 2a str. 301], g...	471.0	[0..1]	[400..1]
gi\|194434382, gi... - gi\|83569157\|ref\|ZP_00920616.1\| COG1488: Nicotinic acid phosphoribosyltransferase [Shigella dysenteri...	470.0	[0..1]	[400..1]
gi\|188488180, gi... - gi\|75512087\|ref\|ZP_00734672.1\| COG1488: Nicotinic acid phosphoribosyltransferase [Escherichia coli 5...	470.0	[0..1]	[400..1]
gi\|226898290, gi... - gi\|237707080\|ref\|ZP_04537561.1\| nicotinate phosphoribosyltransferase [Escherichia sp. 3_2_53FAA], gi... gi\|91071607, gi\|... - gi\|91210033\|ref\|YP_540019.1\| nicotinate phosphoribosyltransferase [Escherichia coli UTI89], gi\|91071... gi\|115512273, gi... - gi\|117623149\|ref\|YP_852062.1\| nicotinate phosphoribosyltransferase [Escherichia coli APEC O1], gi\|11...	470.0	[0..1]	[400..17]
PNCB_SHIDS - Nicotinate phosphoribosyltransferase OS=Shigella dysenteriae serotype 1 (strain Sd197) GN=pncB PE=3 ...	470.0	[0..1]	[400..1]
PNCB_ECO81 - Nicotinate phosphoribosyltransferase OS=Escherichia coli O81 (strain ED1a) GN=pncB PE=3 SV=1 PNCB_ECO45 - Nicotinate phosphoribosyltransferase OS=Escherichia coli O45:K1 (strain S88 / ExPEC) GN=pncB PE=3 SV... gi\|191172074, gi... - gi\|75241006\|ref\|ZP_00724895.1\| COG1488: Nicotinic acid phosphoribosyltransferase [Escherichia coli F...	470.0	[0..1]	[400..1]
gi\|193064666, gi... - gi\|75257352\|ref\|ZP_00728868.1\| COG1488: Nicotinic acid phosphoribosyltransferase [Escherichia coli E... gi\|75210378, gi\|... - gi\|75210378\|ref\|ZP_00710534.1\| COG1488: Nicotinic acid phosphoribosyltransferase [Escherichia coli B...	470.0	[0..1]	[400..1]
gi\|26107358, gi\|... - gi\|26246958\|ref\|NP_752998.1\| nicotinate phosphoribosyltransferase [Escherichia coli CFT073], gi\|2610...	469.0	[0..1]	[400..17]

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Predicted Domain #1

Region A:
Residues: [1-400]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTQFASPVLH SLLDTDAYKL HMQQAVFHHY YDVHVAAEFR CRGDDLLGIY ADAIREQVQA  60
   61 MQHLRLQDDE YQWLSALPFF KADYLNWLRE FRFNPEQVTV SNDNGKLDIR LSGPWREVIL 120
  121 WEVPLLAVIS EMVHRYRSPQ ADVAQALDTL ESKLVDFSAL TAGLDMSRFH LMDFGTRRRF 180
  181 SREVQETIVK RLQQESWFVG TSNYDLARRL SLTPMGTQAH EWFQAHQQIS PDLANSQRAA 240
  241 LAAWLEEYPD QLGIALTDCI TMDAFLRDFG VEFASRYQGL RHDSGDPVEW GEKAIAHYEK 300
  301 LGIDPQSKTL VFSDNLDLRK AVELYRHFSS RVQLSFGIGT RLTCDIPQVK PLNIVIKLVE 360
  361 CNGKPVAKLS DSPGKTICHD KAFVRALRKA FDLPHIKKAS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	117.0
Match:	1yirA
Description:	Crystal Structure of a Nicotinate Phosphoribosyltransferase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
nicotinate phosphoribosyltransferase activity	5.75487746784842	bayes_pls_golite062009
transferase activity, transferring glycosyl groups	4.79136593406808	bayes_pls_golite062009
nicotinate-nucleotide diphosphorylase (carboxylating) activity	3.97201856258863	bayes_pls_golite062009
transferase activity, transferring pentosyl groups	3.41342374351311	bayes_pls_golite062009
catalytic activity	2.59603106157451	bayes_pls_golite062009
transferase activity	1.91642626258277	bayes_pls_golite062009
binding	1.73051405037757	bayes_pls_golite062009
protein binding	0.294646489785198	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: