YRC Public Data Repository - Protein Structure Prediction

Protein:	PIMT_ECOLI
Organism:	Escherichia coli
Length:	208 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PIMT_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|84390120, gi\|... - gi\|84390120\|ref\|ZP_00991382.1\| protein-L-isoaspartate O-methyltransferase [Vibrio splendidus 12B01],...	197.0	[0..1]	[208..1]
PIMT_VIBTL - Protein-L-isoaspartate O-methyltransferase OS=Vibrio tasmaniensis (strain LGP32) GN=pcm PE=3 SV=1 gi\|86146343, gi\|... - gi\|86146343\|ref\|ZP_01064667.1\| protein-L-isoaspartate O-methyltransferase [Vibrio sp. MED222], gi\|85...	196.0	[0..1]	[208..1]
PIMT_VIBCH - Protein-L-isoaspartate O-methyltransferase OS=Vibrio cholerae serotype O1 (strain ATCC 39315 / El To... PIMT_VIBCM - Protein-L-isoaspartate O-methyltransferase OS=Vibrio cholerae serotype O1 (strain M66-2) GN=pcm PE=3... gi\|254291217, gi... - gi\|254291217\|ref\|ZP_04962013.1\| protein-L-isoaspartate O-methyltransferase [Vibrio cholerae AM-19226... gi\|229355888, gi... - gi\|229507143\|ref\|ZP_04396649.1\| protein-L-isoaspartate O-methyltransferase [Vibrio cholerae BX 33028... gi\|194534645, gi... - gi\|75823720\|ref\|ZP_00753204.1\| COG2518: Protein-L-isoaspartate carboxylmethyltransferase [Vibrio cho... gi\|148874595, gi... - gi\|153829907\|ref\|ZP_01982574.1\| protein-L-isoaspartate O-methyltransferase [Vibrio cholerae 623-39],... gi\|229350051, gi... - gi\|229512802\|ref\|ZP_04402269.1\| protein-L-isoaspartate O-methyltransferase [Vibrio cholerae TMA 21],... gi\|116188174, gi... - gi\|75829244\|ref\|ZP_00758554.1\| COG2518: Protein-L-isoaspartate carboxylmethyltransferase [Vibrio cho... gi\|149739237, gi... - gi\|153826934\|ref\|ZP_01979601.1\| protein-L-isoaspartate O-methyltransferase [Vibrio cholerae MZO-2], ... gi\|229519662, gi... - gi\|229519662\|ref\|ZP_04409105.1\| protein-L-isoaspartate O-methyltransferase [Vibrio cholerae RC9], gi... PIMT_VIBC3 - Protein-L-isoaspartate O-methyltransferase OS=Vibrio cholerae serotype O1 (strain ATCC 39541 / Class... gi\|229520828, gi... - gi\|229520828\|ref\|ZP_04410250.1\| protein-L-isoaspartate O-methyltransferase [Vibrio cholerae TM 11079... gi\|75819253, gi\|... - gi\|75819253\|ref\|ZP_00749342.1\| COG2518: Protein-L-isoaspartate carboxylmethyltransferase [Vibrio cho... gi\|229525196, gi... - gi\|229525196\|ref\|ZP_04414601.1\| protein-L-isoaspartate O-methyltransferase [Vibrio cholerae bv. albe... gi\|75815680, gi\|... - gi\|75815680\|ref\|ZP_00746177.1\| COG2518: Protein-L-isoaspartate carboxylmethyltransferase [Vibrio cho... gi\|229606178, gi... - gi\|229606178\|ref\|YP_002876826.1\| protein-L-isoaspartate O-methyltransferase [Vibrio cholerae MJ-1236... gi\|121547479, gi... - gi\|121590693\|ref\|ZP_01678026.1\| protein-L-isoaspartate O-methyltransferase [Vibrio cholerae 2740-80]... gi\|153214940, gi... - gi\|153214940\|ref\|ZP_01949723.1\| protein-L-isoaspartate O-methyltransferase [Vibrio cholerae 1587], g... gi\|153223831, gi... - gi\|153223831\|ref\|ZP_01954086.1\| protein-L-isoaspartate O-methyltransferase [Vibrio cholerae MAK 757]... gi\|153802554, gi... - gi\|153802554\|ref\|ZP_01957140.1\| protein-L-isoaspartate O-methyltransferase [Vibrio cholerae MZO-3], ... PIMT_VIBCH - Protein-L-isoaspartate O-methyltransferase OS=Vibrio cholerae GN=pcm PE=3 SV=1 gi\|126510353, gi... - gi\|153819121\|ref\|ZP_01971788.1\| protein-L-isoaspartate O-methyltransferase [Vibrio cholerae NCTC 845... gi\|229353919, gi... - gi\|229508994\|ref\|ZP_04398482.1\| protein-L-isoaspartate O-methyltransferase [Vibrio cholerae B33], gi...	190.0	[0..1]	[208..1]
PIMT_VIBPA - Protein-L-isoaspartate O-methyltransferase OS=Vibrio parahaemolyticus GN=pcm PE=3 SV=1 PIMT_VIBPA - Protein-L-isoaspartate O-methyltransferase OS=Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 22... gi\|149747268, gi... - gi\|153839203\|ref\|ZP_01991870.1\| protein-L-isoaspartate O-methyltransferase [Vibrio parahaemolyticus ...	187.0	[0..1]	[208..1]
gi\|254230504, gi... - gi\|75854080\|ref\|ZP_00761799.1\| COG2518: Protein-L-isoaspartate carboxylmethyltransferase [Vibrio sp....	187.0	[0..1]	[208..1]
gi\|91204215 - gi\|91204215\|emb\|CAJ71868.1\| strongly similar to protein-L-isoaspartate O-methyltransferase [Candidat...	187.0	[0..4]	[205..40]
gi\|90580344, gi\|... - gi\|90580344\|ref\|ZP_01236151.1\| protein-L-isoaspartate O-methyltransferase [Vibrio angustum S14], gi\|...	186.0	[0..9]	[208..10]
PIMT_VIBF1 - Protein-L-isoaspartate O-methyltransferase OS=Vibrio fischeri (strain ATCC 700601 / ES114) GN=pcm PE...	186.0	[0..1]	[208..1]
PIMT_ERWCT - Protein-L-isoaspartate O-methyltransferase OS=Erwinia carotovora subsp. atroseptica GN=pcm PE=3 SV=1 PIMT_PECAS - Protein-L-isoaspartate O-methyltransferase OS=Pectobacterium atrosepticum (strain SCRI 1043 / ATCC B...	186.0	[0..1]	[208..1]
gi\|89075070, gi\|... - gi\|89075070\|ref\|ZP_01161511.1\| protein-L-isoaspartate O-methyltransferase [Photobacterium sp. SKA34]...	186.0	[0..9]	[208..10]

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Predicted Domain #1

Region A:
Residues: [1-208]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVSRRVQALL DQLRAQGIQD EQVLNALAAV PREKFVDEAF EQKAWDNIAL PIGQGQTISQ  60
   61 PYMVARMTEL LELTPQSRVL EIGTGSGYQT AILAHLVQHV CSVERIKGLQ WQARRRLKNL 120
  121 DLHNVSTRHG DGWQGWQARA PFDAIIVTAA PPEIPTALMT QLDEGGILVL PVGEEHQYLK 180
  181 RVRRRGGEFI IDTVEAVRFV PLVKGELA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	40.221849
Match:	1jg1A
Description:	Protein-L-isoaspartyl O-methyltransferase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein methyltransferase activity	4.65643463984431	bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity	4.4632173842967	bayes_pls_golite062009
methyltransferase activity	4.15445027778357	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	4.07153733729662	bayes_pls_golite062009
N-methyltransferase activity	3.67177992319602	bayes_pls_golite062009
histone methyltransferase activity	3.4768933204909	bayes_pls_golite062009
protein-arginine N-methyltransferase activity	2.91440420216458	bayes_pls_golite062009
arginine N-methyltransferase activity	2.91440420216458	bayes_pls_golite062009
O-methyltransferase activity	2.46301422147246	bayes_pls_golite062009
histone-arginine N-methyltransferase activity	2.45397942930513	bayes_pls_golite062009
protein-L-isoaspartate (D-aspartate) O-methyltransferase activity	2.27866575945018	bayes_pls_golite062009
transferase activity	2.22303238506686	bayes_pls_golite062009
protein-arginine omega-N monomethyltransferase activity	2.07640017323617	bayes_pls_golite062009
DNA-methyltransferase activity	1.63765148226572	bayes_pls_golite062009
histone methyltransferase activity (H4-R3 specific)	1.52139371235933	bayes_pls_golite062009
protein-arginine omega-N asymmetric methyltransferase activity	1.40758086578142	bayes_pls_golite062009
catalytic activity	1.25333584501255	bayes_pls_golite062009
RNA methyltransferase activity	0.817509452491588	bayes_pls_golite062009
site-specific DNA-methyltransferase (adenine-specific) activity	0.703178429468566	bayes_pls_golite062009
binding	0.546744797014504	bayes_pls_golite062009
DNA binding	0.521678594448	bayes_pls_golite062009
transcription regulator activity	0.484890512613189	bayes_pls_golite062009
protein-arginine omega-N symmetric methyltransferase activity	0.328046788565125	bayes_pls_golite062009
nucleic acid binding	0.325924575228933	bayes_pls_golite062009
rRNA methyltransferase activity	0.230719796976667	bayes_pls_golite062009
thiopurine S-methyltransferase activity	0.202037310214077	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: