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View Structure Prediction Details

Protein: gi|55647849
Organism: Pan troglodytes
Length: 291 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|55647849.

Description E-value Query
Range
Subject
Range
gi|109122751 - gi|109122751|ref|XP_001095979.1| PREDICTED: similar to methyl-CpG binding domain protein 3 [Macaca m...
0.0 [1..291] [1..291]
MBD3_MOUSE - Methyl-CpG-binding domain protein 3 OS=Mus musculus GN=Mbd3 PE=1 SV=1
gi|5731992 - gi|5731992|gb|AAD48909.1|AF120995_1 methyl-CpG binding domain-containing protein 3 [Mus musculus dom...
gi|55715962 - gb|AAH86183.1| Unknown (protein for MGC:98642) [Xenopus laevis]
0.0 [1..267] [1..267]
gi|73987317, gi|... - gi|73987325|ref|XP_868594.1| PREDICTED: similar to methyl-CpG binding domain protein 3 isoform 5 [Ca...
0.0 [1..291] [1..291]
gi|47215634 - gi|47215634|emb|CAG01351.1| unnamed protein product [Tetraodon nigroviridis]
0.0 [1..260] [1..260]
gi|24210495 - gi|24210495|dbj|BAC22082.1| methyl-CpG binding protein MBD3 [Xenopus laevis]
0.0 [1..262] [1..262]
gi|37681869, gi|... - gi|47086507|ref|NP_997934.1| methyl-CpG binding domain protein 3a [Danio rerio], gi|37681869|gb|AAQ9...
0.0 [1..270] [1..269]

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Predicted Domain #1
Region A:
Residues: [1-78]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MERKRWECPA LPQGWEREEV PRRSGLSAGH RDVFYYSPSG KKFRSKPQLA RYLGGSMDLS  60
   61 TFDFRTGKML MSKMNKSR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 26.522879
Match: 1d9nA
Description: Methylation-dependent transcriptional repressor MBD1/PCM1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
methyl-CpG binding 4.54540676267869 bayes_pls_golite062009
DNA binding 4.42562920230852 bayes_pls_golite062009
nucleic acid binding 4.33195028920652 bayes_pls_golite062009
double-stranded methylated DNA binding 4.13704647712557 bayes_pls_golite062009
unmethylated CpG binding 4.11290155206252 bayes_pls_golite062009
transcription repressor activity 3.19559870959168 bayes_pls_golite062009
binding 3.0325775548747 bayes_pls_golite062009
chromatin binding 2.99247237408109 bayes_pls_golite062009
transcription regulator activity 2.97633361410339 bayes_pls_golite062009
transcription corepressor activity 2.70291730403476 bayes_pls_golite062009
sequence-specific DNA binding 2.42722575436746 bayes_pls_golite062009
transcription factor activity 2.27540830787547 bayes_pls_golite062009
transcription factor binding 1.67549684739333 bayes_pls_golite062009
transcription cofactor activity 1.53919976183276 bayes_pls_golite062009
protein binding 1.48651016577672 bayes_pls_golite062009
DNA secondary structure binding 1.40804604506756 bayes_pls_golite062009
four-way junction DNA binding 1.09532938985367 bayes_pls_golite062009
nucleotide binding 0.409742306544047 bayes_pls_golite062009
RNA binding 0.33612198087066 bayes_pls_golite062009
mRNA binding 0.28477406293958 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [79-196]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QRVRYDSSNQ VKGKPDLNTA LPVRQTASIF KQPVTKITNH PSNKVKSDPQ KAVDQPRQLF  60
   61 WEKKLSGLNA FDIAEELVKT MDLPKGLQGV GPGCTDETLL SAIASALHTS TMPITGQL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [197-291]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SAAVEKNPGV WLNTTQPLCK AFMVTDEDIR KQEELVQQVR KRLEEALMAD MLAHVEELAR  60
   61 DGEAPLDKAC AEDDDEEDEE EEEEEPDPDP EMEHV

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle