YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|25316275
Organism:	Yersinia pestis
Length:	329 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|25316275.

Description	E-value	Query Range	Subject Range
gi\|117622575, gi... - gi\|117622575\|ref\|YP_851488.1\| putative aldo/keto reductase [Escherichia coli APEC O1], gi\|115511699\|... gi\|91209365, gi\|... - gi\|91209365\|ref\|YP_539351.1\| putative aldo/keto reductase [Escherichia coli UTI89], gi\|91070939\|gb\|A... gi\|226898921, gi... - gi\|237707711\|ref\|ZP_04538192.1\| conserved hypothetical protein [Escherichia sp. 3_2_53FAA], gi\|22689... gi\|218363986, gi... - gi\|218557217\|ref\|YP_002390130.1\| putative aldo-keto reductase [Escherichia coli S88], gi\|218363986\|e...	8.0E-96	[1..329]	[1..329]
gi\|67156318 - gi\|67156318\|ref\|ZP_00417911.1\| Aldo/keto reductase [Azotobacter vinelandii AvOP] gi\|226945848, gi... - gi\|67156318\|ref\|ZP_00417911.1\| Aldo/keto reductase [Azotobacter vinelandii AvOP], gi\|67086077\|gb\|EAM...	2.0E-95	[1..329]	[1..329]
gi\|191173551, gi... - gi\|75238515\|ref\|ZP_00722509.1\| COG0667: Predicted oxidoreductases (related to aryl-alcohol dehydroge... gi\|110342162, gi... - gi\|110640570\|ref\|YP_668298.1\| putative aldo/keto reductase [Escherichia coli 536], gi\|110342162\|gb\|A... gi\|26246311, gi\|... - gi\|26246311\|ref\|NP_752350.1\| putative aldo/keto reductase [Escherichia coli CFT073], gi\|26106709\|gb\|... gi\|227884690, gi... - gi\|227884690\|ref\|ZP_04002495.1\| possible pyridoxine 4-dehydrogenase [Escherichia coli 83972], gi\|227...	2.0E-95	[1..329]	[1..329]
gi\|48786861, gi\|... - gi\|91778170\|ref\|YP_553378.1\| aldo/keto reductase [Burkholderia xenovorans LB400], gi\|91690830\|gb\|ABE...	2.0E-95	[1..329]	[1..329]
gi\|21957876, gi\|... - gi\|22125028\|ref\|NP_668451.1\| oxidoreductase [Yersinia pestis KIM], gi\|21957876\|gb\|AAM84702.1\|AE01371... gi\|45440991, gi\|... - gi\|45440991\|ref\|NP_992530.1\| putative aldo/keto reductase [Yersinia pestis biovar Microtus str. 9100...	6.0E-95	[1..329]	[2..330]
gi\|241904018, gi... - gi\|241904018\|ref\|ZP_04788730.1\| aldo/keto reductase [Thermoanaerobacter brockii subsp. finnii Ako-1]... gi\|166856834, gi... - gi\|76796502\|ref\|ZP_00778863.1\| Aldo/keto reductase [Thermoanaerobacter ethanolicus ATCC 33223], gi\|7...	9.0E-95	[1..329]	[1..331]
gi\|85775968, gi\|... - gi\|86159457\|ref\|YP_466242.1\| aldo/keto reductase [Anaeromyxobacter dehalogenans 2CP-C], gi\|85775968\|...	1.0E-94	[1..328]	[1..327]
gi\|50119681, gi\|... - gi\|50119681\|ref\|YP_048848.1\| putative aldo/keto reductase [Pectobacterium atrosepticum SCRI1043], gi...	2.0E-94	[1..329]	[1..330]
gi\|148265548, gi... - gi\|88934427\|ref\|ZP_01140070.1\| probable oxidoreductase [Geobacter uraniumreducens Rf4], gi\|88918885\|...	3.0E-94	[1..329]	[1..328]

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Predicted Domain #1

Region A:
Residues: [1-329]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQKRYLGKSG LEVSALGLGC MGLSYGYGPA TDTRQAVELI RAAVERGVTF FDTAEVYGPY  60
   61 LNEEVVGEAL KPFRDQVVIA TKFGFTFGED NKQQILNSRP EHIREAVEGS LRRLKTDVID 120
  121 LLYQHRVDPD VPIEDVAGTV KDLIAEGKVK HFGLSEAGAQ TIRRAHAIQP VAALQSEYSM 180
  181 WWREPEQEIL PLLEELGIGF VPFSPLGKGF LTGAIKAGAT FGEDDFRSKV PRFAAEALEA 240
  241 NERLVALLGI LAAEKGVTSA QIALAWLLAQ KPWIVPIPGT TKLHRLEENL GAADITLSQD 300
  301 DIWNITQALA TVKIVGERYP AAMQARVGR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	79.221849
Match:	1pyfA
Description:	Structure of NADPH-dependent family 11 aldo-keto reductase AKR11A(apo)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
pyridoxine 4-dehydrogenase activity	3.25535446462297	bayes_pls_golite062009
aldo-keto reductase activity	2.57303336304449	bayes_pls_golite062009
aryl-alcohol dehydrogenase activity	2.5168190536972	bayes_pls_golite062009
catalytic activity	1.68179794468736	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	1.48881830724998	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	1.47641884930911	bayes_pls_golite062009
oxidoreductase activity	1.17915737521094	bayes_pls_golite062009
aldehyde reductase activity	1.16639404121425	bayes_pls_golite062009
binding	0.750554688914866	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: