YRC Public Data Repository - Protein Structure Prediction

Protein:	METK_ECOLI
Organism:	Escherichia coli
Length:	384 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for METK_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|254037990, gi... - gi\|254037990\|ref\|ZP_04872048.1\| S-adenosylmethionine synthetase [Escherichia sp. 1_1_43], gi\|2268396... gi\|91073898, gi\|... - gi\|91212324\|ref\|YP_542310.1\| S-adenosylmethionine synthetase [Escherichia coli UTI89], gi\|91073898\|g... gi\|226899446, gi... - gi\|237706406\|ref\|ZP_04536887.1\| S-adenosylmethionine synthetase [Escherichia sp. 3_2_53FAA], gi\|2268... gi\|24114197, gi\|... - ref\|NP_708707.1\| methionine adenosyltransferase 1 (AdoMet synthetase); methyl and propylamine donor,... gi\|26109771, gi\|... - gi\|26249363\|ref\|NP_755403.1\| S-adenosylmethionine synthetase [Escherichia coli CFT073], gi\|26109771\|...	715.0	[0..1]	[384..5]
METK_PHOLL - S-adenosylmethionine synthase OS=Photorhabdus luminescens subsp. laumondii GN=metK PE=3 SV=1 METK_PHOLL - S-adenosylmethionine synthase OS=Photorhabdus luminescens subsp. laumondii (strain DSM 15139 / CIP 1...	713.0	[0..1]	[384..1]
METK_SHIB3 - S-adenosylmethionine synthase OS=Shigella boydii serotype 18 (strain CDC 3083-94 / BS512) GN=metK PE... METK_SHIBS - S-adenosylmethionine synthase OS=Shigella boydii serotype 4 (strain Sb227) GN=metK PE=3 SV=1	712.0	[0..1]	[384..1]
gi\|238798628, gi... - gi\|77961486\|ref\|ZP_00825322.1\| COG0192: S-adenosylmethionine synthetase [Yersinia mollaretii ATCC 43...	711.0	[0..1]	[384..1]
gi\|195633475, gi... - gi\|195633475\|gb\|EDX51889.1\| S-adenosylmethionine synthetase [Salmonella enterica subsp. enterica ser... METK_SALCH - S-adenosylmethionine synthase OS=Salmonella choleraesuis (strain SC-B67) GN=metK PE=3 SV=1 gi\|205347064, gi... - gi\|205347064\|gb\|EDZ33695.1\| S-adenosylmethionine synthetase [Salmonella enterica subsp. enterica ser... METK_SALPA - S-adenosylmethionine synthase OS=Salmonella paratyphi A (strain ATCC 9150 / SARB42) GN=metK PE=3 SV=... gi\|168236158, gi... - gi\|197290694\|gb\|EDY30048.1\| S-adenosylmethionine synthetase [Salmonella enterica subsp. enterica ser... gi\|205331702, gi... - gi\|205331702\|gb\|EDZ18466.1\| S-adenosylmethionine synthetase [Salmonella enterica subsp. enterica ser... METK_SALSV - S-adenosylmethionine synthase OS=Salmonella schwarzengrund (strain CVM19633) GN=metK PE=3 SV=1 gi\|194456435, gi... - gi\|194470071\|ref\|ZP_03076055.1\| S-adenosylmethionine synthetase [Salmonella enterica subsp. enterica... METK_SALNS - S-adenosylmethionine synthase OS=Salmonella newport (strain SL254) GN=metK PE=3 SV=1 gi\|168819881, gi... - gi\|205343447\|gb\|EDZ30211.1\| S-adenosylmethionine synthetase [Salmonella enterica subsp. enterica ser... gi\|167990384, gi... - gi\|205331134\|gb\|EDZ17898.1\| S-adenosylmethionine synthetase [Salmonella enterica subsp. enterica ser... gi\|205322287, gi... - gi\|205322287\|gb\|EDZ10126.1\| S-adenosylmethionine synthetase [Salmonella enterica subsp. enterica ser... METK_SALCH - S-adenosylmethionine synthetase OS=Salmonella choleraesuis GN=metK PE=3 SV=1 gi\|29143352, gi\|... - gi\|29143352\|ref\|NP_806694.1\| S-adenosylmethionine synthetase [Salmonella enterica subsp. enterica se... gi\|16761865 - gi\|16761865\|ref\|NP_457482.1\| S-adenosylmethionine synthetase [Salmonella enterica subsp. enterica se... METK_SALPA - S-adenosylmethionine synthase OS=Salmonella paratyphi A GN=metK PE=3 SV=1 METK_SALCH - S-adenosylmethionine synthase OS=Salmonella choleraesuis GN=metK PE=3 SV=1 gi\|204322717, gi... - gi\|204928395\|ref\|ZP_03219595.1\| S-adenosylmethionine synthetase [Salmonella enterica subsp. enterica... METK_SALTY - S-adenosylmethionine synthase OS=Salmonella typhimurium GN=metK PE=3 SV=2 gi\|200387327, gi... - gi\|200387327\|ref\|ZP_03213939.1\| S-adenosylmethionine synthetase [Salmonella enterica subsp. enterica... METK_SALPK - S-adenosylmethionine synthase OS=Salmonella paratyphi A (strain AKU_12601) GN=metK PE=3 SV=1 gi\|197243409, gi... - gi\|197265154\|ref\|ZP_03165228.1\| S-adenosylmethionine synthetase [Salmonella enterica subsp. enterica... gi\|214002394 - gi\|214002394\|ref\|ZP_03413129.1\| S-adenosylmethionine synthetase [Salmonella enterica subsp. enterica... gi\|213648501 - gi\|213648501\|ref\|ZP_03378554.1\| S-adenosylmethionine synthetase [Salmonella enterica subsp. enterica... gi\|213163035 - gi\|213163035\|ref\|ZP_03348745.1\| S-adenosylmethionine synthetase [Salmonella enterica subsp. enterica... METK_SALEP - S-adenosylmethionine synthase OS=Salmonella enteritidis PT4 (strain P125109) GN=metK PE=3 SV=1 lcl\|NC_016856.1_... - [gene=metK] [protein=S-adenosylmethionine synthetase] [protein_id=YP_005239235.1] [location=3270814.... gi\|238909888 - gi\|238909888\|ref\|ZP_04653725.1\| S-adenosylmethionine synthetase [Salmonella enterica subsp. enterica... METK_SALTI - S-adenosylmethionine synthase OS=Salmonella typhi GN=metK PE=3 SV=2 METK_SALTY - S-adenosylmethionine synthase OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=met... METK_SALTI - S-adenosylmethionine synthetase OS=Salmonella typhi GN=metK PE=3 SV=2 METK_SALTY - S-adenosylmethionine synthetase OS=Salmonella typhimurium GN=metK PE=3 SV=2	711.0	[0..1]	[384..1]
gi\|238725540, gi... - gi\|77976235\|ref\|ZP_00831745.1\| COG0192: S-adenosylmethionine synthetase [Yersinia intermedia ATCC 29...	711.0	[0..1]	[384..1]
METK_ECOLI - (P0A817) S-adenosylmethionine synthetase (EC 2.5.1.6) (Methionine adenosyltransferase) (AdoMet synth... METK_SHIFL - (P0A820) S-adenosylmethionine synthetase (EC 2.5.1.6) (Methionine adenosyltransferase) (AdoMet synth... METK_ECO57 - (P0A819) S-adenosylmethionine synthetase (EC 2.5.1.6) (Methionine adenosyltransferase) (AdoMet synth... METK_ECOL6 - (P0A818) S-adenosylmethionine synthetase (EC 2.5.1.6) (Methionine adenosyltransferase) (AdoMet synth...	710.0	[0..2]	[384..1]
gi\|77956703, gi\|... - gi\|77956703\|ref\|ZP_00820786.1\| COG0192: S-adenosylmethionine synthetase [Yersinia bercovieri ATCC 43...	708.0	[0..1]	[384..1]
gi\|21960256, gi\|... - gi\|22127190\|ref\|NP_670613.1\| S-adenosylmethionine synthetase [Yersinia pestis KIM], gi\|21960256\|gb\|A... METK_YERPS - S-adenosylmethionine synthase OS=Yersinia pseudotuberculosis serotype I (strain IP32953) GN=metK PE=... gi\|45443250, gi\|... - gi\|45443250\|ref\|NP_994789.1\| S-adenosylmethionine synthetase [Yersinia pestis biovar Microtus str. 9... METK_YERPE - S-adenosylmethionine synthase OS=Yersinia pestis GN=metK PE=3 SV=1 gi\|115346714, gi... - gi\|218928103\|ref\|YP_002345978.1\| S-adenosylmethionine synthetase [Yersinia pestis CO92], gi\|16121235... gi\|165990834, gi... - gi\|166010348\|ref\|ZP_02231246.1\| S-adenosylmethionine synthetase [Yersinia pestis biovar Antiqua str.... METK_YERPP - S-adenosylmethionine synthase OS=Yersinia pestis (strain Pestoides F) GN=metK PE=3 SV=1 gi\|165923173, gi... - gi\|165924973\|ref\|ZP_02220805.1\| S-adenosylmethionine synthetase [Yersinia pestis biovar Orientalis s... gi\|167399744, gi... - gi\|167399744\|ref\|ZP_02305262.1\| S-adenosylmethionine synthetase [Yersinia pestis biovar Antiqua str.... gi\|166205972, gi... - gi\|166212680\|ref\|ZP_02238715.1\| S-adenosylmethionine synthetase [Yersinia pestis biovar Antiqua str.... gi\|167426700, gi... - gi\|167426700\|ref\|ZP_02318453.1\| S-adenosylmethionine synthetase [Yersinia pestis biovar Mediaevalis ... gi\|167421931, gi... - gi\|167421931\|ref\|ZP_02313684.1\| S-adenosylmethionine synthetase [Yersinia pestis biovar Orientalis s... METK_YERPB - S-adenosylmethionine synthase OS=Yersinia pseudotuberculosis serotype IB (strain PB1/+) GN=metK PE=3... gi\|229704308, gi... - gi\|229837620\|ref\|ZP_04457782.1\| methionine adenosyltransferase 1 [Yersinia pestis Pestoides A], gi\|2... METK_YERPY - S-adenosylmethionine synthase OS=Yersinia pseudotuberculosis serotype O:3 (strain YPIII) GN=metK PE=... gi\|229697213, gi... - gi\|229840847\|ref\|ZP_04461006.1\| methionine adenosyltransferase 1 [Yersinia pestis biovar Orientalis ... gi\|229842593, gi... - gi\|229842593\|ref\|ZP_04462748.1\| methionine adenosyltransferase 1 [Yersinia pestis biovar Orientalis ... gi\|149290674, gi... - gi\|149367060\|ref\|ZP_01889093.1\| S-adenosylmethionine synthetase [Yersinia pestis CA88-4125], gi\|1492... METK_YERPG - S-adenosylmethionine synthase OS=Yersinia pestis bv. Antiqua (strain Angola) GN=metK PE=3 SV=1 METK_YERP3 - S-adenosylmethionine synthase OS=Yersinia pseudotuberculosis serotype O:1b (strain IP 31758) GN=metK... METK_YERPN - S-adenosylmethionine synthase OS=Yersinia pestis bv. Antiqua (strain Nepal516) GN=metK PE=3 SV=1 METK_YERPS - S-adenosylmethionine synthase OS=Yersinia pseudotuberculosis GN=metK PE=3 SV=1 gi\|165937296, gi... - gi\|89104334\|ref\|ZP_01176880.1\| COG0192: S-adenosylmethionine synthetase [Yersinia pestis biovar Orie... METK_YERPA - S-adenosylmethionine synthase OS=Yersinia pestis bv. Antiqua (strain Antiqua) GN=metK PE=3 SV=1	707.0	[0..1]	[384..1]
gi\|77974474, gi\|... - gi\|77974474\|ref\|ZP_00830014.1\| COG0192: S-adenosylmethionine synthetase [Yersinia frederiksenii ATCC...	706.0	[0..1]	[384..1]

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Predicted Domain #1

Region A:
Residues: [1-384]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAKHLFTSES VSEGHPDKIA DQISDAVLDA ILEQDPKARV ACETYVKTGM VLVGGEITTS  60
   61 AWVDIEEITR NTVREIGYVH SDMGFDANSC AVLSAIGKQS PDINQGVDRA DPLEQGAGDQ 120
  121 GLMFGYATNE TDVLMPAPIT YAHRLVQRQA EVRKNGTLPW LRPDAKSQVT FQYDDGKIVG 180
  181 IDAVVLSTQH SEEIDQKSLQ EAVMEEIIKP ILPAEWLTSA TKFFINPTGR FVIGGPMGDC 240
  241 GLTGRKIIVD TYGGMARHGG GAFSGKDPSK VDRSAAYAAR YVAKNIVAAG LADRCEIQVS 300
  301 YAIGVAEPTS IMVETFGTEK VPSEQLTLLV REFFDLRPYG LIQMLDLLHP IYKETAAYGH 360
  361 FGREHFPWEK TDKAQLLRDA AGLK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1000.0
Match:	1fugA
Description:	S-adenosylmethionine synthetase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
methionine adenosyltransferase activity	8.00759843092519	bayes_pls_golite062009
transferase activity	1.78879119839291	bayes_pls_golite062009
binding	1.70779292877479	bayes_pls_golite062009
catalytic activity	1.59111295908728	bayes_pls_golite062009
transferase activity, transferring alkyl or aryl (other than methyl) groups	1.11999094477144	bayes_pls_golite062009
protein binding	0.298204436433395	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: