YRC Public Data Repository - Protein Structure Prediction

Protein:	GCH1_ECOLI
Organism:	Escherichia coli
Length:	222 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GCH1_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|7435996 - gi\|7435996\|pir\|\|S29895 GTP cyclohydrolase I (EC 3.5.4.16) - Escherichia coli	310.0	[0..1]	[222..1]
gi\|254285641, gi... - gi\|254285641\|ref\|ZP_04960604.1\| GTP cyclohydrolase [Vibrio cholerae AM-19226], gi\|197752713\|ref\|YP_0... gi\|150420170, gi... - gi\|254223367\|ref\|ZP_04917220.1\| GTP cyclohydrolase [Vibrio cholerae RC385], gi\|194535376\|ref\|YP_0020... gi\|148873579, gi... - gi\|153830946\|ref\|ZP_01983613.1\| GTP cyclohydrolase [Vibrio cholerae 623-39], gi\|148873579\|gb\|EDL7171... gi\|153824469, gi... - gi\|153824469\|ref\|ZP_01977136.1\| GTP cyclohydrolase [Vibrio cholerae MZO-2], gi\|149742023\|gb\|EDM56052... gi\|227015324, gi... - gi\|227119874\|ref\|YP_002821769.1\| GTP cyclohydrolase [Vibrio cholerae O395], gi\|227015324\|gb\|ACP11533... gi\|9658028, gi\|1... - gi\|9658028\|gb\|AAF96517.1\| GTP cyclohydrolase [Vibrio cholerae O1 biovar eltor str. N16961], gi\|15601... gi\|11354990 - gi\|11354990\|pir\|\|D82439 GTP cyclohydrolase VCA0616 [imported] - Vibrio cholerae (strain N16961 sero... gi\|121631668, gi... - gi\|121725903\|ref\|ZP_01679203.1\| GTP cyclohydrolase [Vibrio cholerae V52], gi\|121631668\|gb\|EAX64036.1... gi\|121587480, gi... - gi\|121587480\|ref\|ZP_01677248.1\| GTP cyclohydrolase [Vibrio cholerae 2740-80], gi\|121548315\|gb\|EAX583... gi\|124121722, gi... - gi\|153802726\|ref\|ZP_01957312.1\| GTP cyclohydrolase [Vibrio cholerae MZO-3], gi\|124121722\|gb\|EAY40465... gi\|124116966, gi... - gi\|153211890\|ref\|ZP_01947737.1\| GTP cyclohydrolase [Vibrio cholerae 1587], gi\|124116966\|gb\|EAY35786.... gi\|194537613, gi... - gi\|254225127\|ref\|ZP_04918740.1\| GTP cyclohydrolase [Vibrio cholerae V51], gi\|194537613\|ref\|YP_002072... gi\|125619456 - gi\|125619456\|gb\|EAZ47984.1\| GTP cyclohydrolase [Vibrio cholerae MO10] gi\|227812183, gi... - gi\|227812183\|ref\|YP_002812193.1\| GTP cyclohydrolase [Vibrio cholerae M66-2], gi\|227011325\|gb\|ACP0753... gi\|126511489, gi... - gi\|153817951\|ref\|ZP_01970618.1\| GTP cyclohydrolase [Vibrio cholerae NCTC 8457], gi\|126511489\|gb\|EAZ7...	306.0	[0..1]	[219..14]
gi\|90579745, gi\|... - gi\|90579745\|ref\|ZP_01235554.1\| GTP cyclohydrolase I [Vibrio angustum S14], gi\|90439319\|gb\|EAS64501.1...	306.0	[0..1]	[219..1]
gi\|254849776, gi... - gi\|75831523\|ref\|ZP_00760786.1\| COG0302: GTP cyclohydrolase I [Vibrio cholerae MO10], gi\|254849776\|re... GCH1_VIBCH - GTP cyclohydrolase 1 OS=Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) GN=fol... gi\|229356568, gi... - gi\|229506217\|ref\|ZP_04395726.1\| GTP cyclohydrolase I type 1 [Vibrio cholerae BX 330286], gi\|22935656... gi\|229509924, gi... - gi\|229509924\|ref\|ZP_04399404.1\| GTP cyclohydrolase I type 1 [Vibrio cholerae B33], gi\|229352369\|gb\|E... gi\|229349605, gi... - gi\|229513195\|ref\|ZP_04402660.1\| GTP cyclohydrolase I type 1 [Vibrio cholerae TMA 21], gi\|229349605\|g... gi\|229346396, gi... - gi\|229516515\|ref\|ZP_04405962.1\| GTP cyclohydrolase I type 1 [Vibrio cholerae RC9], gi\|229346396\|gb\|E... gi\|229523112, gi... - gi\|229523112\|ref\|ZP_04412524.1\| GTP cyclohydrolase I type 1 [Vibrio cholerae TM 11079-80], gi\|229339... gi\|229525973, gi... - gi\|229525973\|ref\|ZP_04415377.1\| GTP cyclohydrolase I type 1 [Vibrio cholerae bv. albensis VL426], gi... gi\|229528553, gi... - gi\|229528553\|ref\|ZP_04417944.1\| GTP cyclohydrolase I type 1 [Vibrio cholerae 12129(1)], gi\|229334915... gi\|229605757, gi... - gi\|229605757\|ref\|YP_002876461.1\| GTP cyclohydrolase I type 1 [Vibrio cholerae MJ-1236], gi\|229372243... gi\|124120549, gi... - gi\|153219989\|ref\|ZP_01951558.1\| GTP cyclohydrolase I [Vibrio cholerae MAK 757], gi\|124120549\|gb\|EAY3... GCH1_VIBCH - GTP cyclohydrolase 1 OS=Vibrio cholerae GN=folE PE=3 SV=2 gi\|75825439 - gi\|75825439\|ref\|ZP_00754875.1\| COG0302: GTP cyclohydrolase I [Vibrio cholerae O395] gi\|75822045, gi\|... - gi\|75822045\|ref\|ZP_00751756.1\| COG0302: GTP cyclohydrolase I [Vibrio cholerae RC385], gi\|116215375\|r... gi\|75820105, gi\|... - gi\|75820105\|ref\|ZP_00750161.1\| COG0302: GTP cyclohydrolase I [Vibrio cholerae V51], gi\|116220666\|ref... gi\|75817221 - gi\|75817221\|ref\|ZP_00747674.1\| COG0302: GTP cyclohydrolase I [Vibrio cholerae V52]	305.0	[0..1]	[219..1]
gi\|89049336, gi\|... - gi\|89074939\|ref\|ZP_01161389.1\| GTP cyclohydrolase I [Photobacterium sp. SKA34], gi\|89049336\|gb\|EAR54...	305.0	[0..1]	[219..1]
GCH1_SALPB - GTP cyclohydrolase 1 OS=Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7) GN=folE PE=3 SV=1 GCH1_SALPA - GTP cyclohydrolase 1 OS=Salmonella paratyphi A GN=folE PE=3 SV=1 GCH1_SALHS - GTP cyclohydrolase 1 OS=Salmonella heidelberg (strain SL476) GN=folE PE=3 SV=1 gi\|194472483, gi... - gi\|194472483\|ref\|ZP_03078467.1\| GTP cyclohydrolase I [Salmonella enterica subsp. enterica serovar Ke... GCH1_SALSV - GTP cyclohydrolase 1 OS=Salmonella schwarzengrund (strain CVM19633) GN=folE PE=3 SV=1 GCH1_SALA4 - GTP cyclohydrolase 1 OS=Salmonella agona (strain SL483) GN=folE PE=3 SV=1 gi\|205351147, gi... - gi\|205351147\|gb\|EDZ37778.1\| GTP cyclohydrolase I [Salmonella enterica subsp. enterica serovar Hadar ... gi\|195631172, gi... - gi\|195631172\|gb\|EDX49732.1\| GTP cyclohydrolase I [Salmonella enterica subsp. enterica serovar Newpor... GCH1_SALTY - GTP cyclohydrolase 1 OS=Salmonella typhimurium GN=folE PE=3 SV=2 gi\|205344996, gi... - gi\|205344996\|gb\|EDZ31760.1\| GTP cyclohydrolase I [Salmonella enterica subsp. enterica serovar Weltev... GCH1_SALNS - GTP cyclohydrolase 1 OS=Salmonella newport (strain SL254) GN=folE PE=3 SV=1 gi\|205330471, gi... - gi\|205330471\|gb\|EDZ17235.1\| GTP cyclohydrolase I [Salmonella enterica subsp. enterica serovar 4,[5],... gi\|205335919, gi... - gi\|205335919\|gb\|EDZ22683.1\| GTP cyclohydrolase I [Salmonella enterica subsp. enterica serovar Kentuc... gi\|238912894 - gi\|238912894\|ref\|ZP_04656731.1\| GTP cyclohydrolase I [Salmonella enterica subsp. enterica serovar Te... gi\|197290548, gi... - gi\|197290548\|gb\|EDY29903.1\| GTP cyclohydrolase I [Salmonella enterica subsp. enterica serovar Schwar... gi\|168242282, gi... - gi\|205338360\|gb\|EDZ25124.1\| GTP cyclohydrolase I [Salmonella enterica subsp. enterica serovar Heidel... gi\|205323982, gi... - gi\|205323982\|gb\|EDZ11821.1\| GTP cyclohydrolase I [Salmonella enterica subsp. enterica serovar Saintp... GCH1_SALPA - GTP cyclohydrolase 1 OS=Salmonella paratyphi A (strain ATCC 9150 / SARB42) GN=folE PE=3 SV=1 gi\|213646022 - gi\|213646022\|ref\|ZP_03376075.1\| GTP cyclohydrolase I [Salmonella enterica subsp. enterica serovar Ty... gi\|213852217 - gi\|213852217\|ref\|ZP_03381749.1\| GTP cyclohydrolase I [Salmonella enterica subsp. enterica serovar Ty... gi\|214000074 - gi\|214000074\|ref\|ZP_03410809.1\| GTP cyclohydrolase I [Salmonella enterica subsp. enterica serovar Ty... GCH1_SALPC - GTP cyclohydrolase 1 OS=Salmonella paratyphi C (strain RKS4594) GN=folE PE=3 SV=1 gi\|204928962, gi... - gi\|204928962\|ref\|ZP_03220105.1\| GTP cyclohydrolase I [Salmonella enterica subsp. enterica serovar Ja... GCH1_SALEP - GTP cyclohydrolase 1 OS=Salmonella enteritidis PT4 (strain P125109) GN=folE PE=3 SV=1 gi\|213424249 - gi\|213424249\|ref\|ZP_03357108.1\| GTP cyclohydrolase I [Salmonella enterica subsp. enterica serovar Ty... gi\|213582836 - gi\|213582836\|ref\|ZP_03364662.1\| GTP cyclohydrolase I [Salmonella enterica subsp. enterica serovar Ty... gi\|197241150, gi... - gi\|197262895\|ref\|ZP_03162969.1\| GTP cyclohydrolase I [Salmonella enterica subsp. enterica serovar Sa... GCH1_SALPB - GTP cyclohydrolase 1 OS=Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7) GN=folE PE=3 SV=1 GCH1_SALPK - GTP cyclohydrolase 1 OS=Salmonella paratyphi A (strain AKU_12601) GN=folE PE=3 SV=1 GCH1_SALDC - GTP cyclohydrolase 1 OS=Salmonella dublin (strain CT_02021853) GN=folE PE=3 SV=1 gi\|199603984, gi... - gi\|200386886\|ref\|ZP_03213498.1\| GTP cyclohydrolase I [Salmonella enterica subsp. enterica serovar Vi... GCH1_SALTI - GTP cyclohydrolase 1 OS=Salmonella typhi GN=folE PE=3 SV=2 GCH1_SALTY - GTP cyclohydrolase 1 OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=folE PE=3 SV... GCH1_SALTI - GTP cyclohydrolase 1 OS=Salmonella typhi GN=folE PE=3 SV=2 GCH1_SALTY - GTP cyclohydrolase 1 OS=Salmonella typhimurium GN=folE PE=3 SV=2 gi\|29141171, gi\|... - gi\|29141171\|ref\|NP_804513.1\| GTP cyclohydrolase I [Salmonella enterica subsp. enterica serovar Typhi... lcl\|NC_016856.1_... - [gene=folE] [protein=GTP cyclohydrolase I] [protein_id=YP_005238242.1] [location=complement(2341997.... gi\|16761135 - gi\|16761135\|ref\|NP_456752.1\| GTP cyclohydrolase I [Salmonella enterica subsp. enterica serovar Typhi... GCH1_SALAR - GTP cyclohydrolase 1 OS=Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980) GN=folE PE=3...	305.0	[0..1]	[221..1]
GCH1_VIBCB - GTP cyclohydrolase 1 OS=Vibrio campbellii (strain ATCC BAA-1116 / BB120) GN=folE PE=3 SV=1 gi\|91190410, gi\|... - gi\|91224864\|ref\|ZP_01260124.1\| GTP cyclohydrolase I [Vibrio alginolyticus 12G01], gi\|91190410\|gb\|EAS...	304.0	[0..1]	[219..1]
gi\|116187392, gi... - gi\|75856511\|ref\|ZP_00764138.1\| COG0302: GTP cyclohydrolase I [Vibrio sp. Ex25], gi\|254227735\|ref\|ZP_...	303.0	[0..1]	[219..1]
GCH1_SALCH - GTP cyclohydrolase 1 OS=Salmonella choleraesuis (strain SC-B67) GN=folE PE=3 SV=1 GCH1_SALCH - GTP cyclohydrolase 1 OS=Salmonella choleraesuis GN=folE PE=3 SV=1 GCH1_SALCH - GTP cyclohydrolase 1 OS=Salmonella choleraesuis GN=folE PE=3 SV=1	303.0	[0..1]	[221..1]

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Predicted Domain #1

Region A:
Residues: [1-222]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPSLSKEAAL VHEALVARGL ETPLRPPVHE MDNETRKSLI AGHMTEIMQL LNLDLADDSL  60
   61 METPHRIAKM YVDEIFSGLD YANFPKITLI ENKMKVDEMV TVRDITLTST CEHHFVTIDG 120
  121 KATVAYIPKD SVIGLSKINR IVQFFAQRPQ VQERLTQQIL IALQTLLGTN NVAVSIDAVH 180
  181 YCVKARGIRD ATSATTTTSL GGLFKSSQNT RHEFLRAVRH HN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	83.0
Match:	1fbxA
Description:	GTP cyclohydrolase I
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
GTP cyclohydrolase I activity	4.1430878480831	bayes_pls_golite062009
cyclohydrolase activity	3.66553359909123	bayes_pls_golite062009
GTP cyclohydrolase activity	3.44912994722205	bayes_pls_golite062009
catalytic activity	2.20788162511962	bayes_pls_golite062009
dihydroneopterin aldolase activity	1.96466418682643	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	1.73101699306211	bayes_pls_golite062009
binding	1.03236620581563	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	0.974891318710762	bayes_pls_golite062009
urate oxidase activity	0.0294957696532921	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: