YRC Public Data Repository - Protein Structure Prediction

Protein:	AHPC_ECOLI
Organism:	Escherichia coli
Length:	187 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for AHPC_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|78184723, gi\|... - gi\|78184723\|ref\|YP_377158.1\| thioredoxin peroxidase [Synechococcus sp. CC9902], gi\|78169017\|gb\|ABB26...	232.0	[0..2]	[186..10]
gi\|116070595, gi... - gi\|116070595\|ref\|ZP_01467864.1\| thioredoxin peroxidase [Synechococcus sp. BL107], gi\|116066000\|gb\|EA...	232.0	[0..2]	[186..7]
gi\|33865747, gi\|... - gi\|33865747\|ref\|NP_897306.1\| thioredoxin peroxidase [Synechococcus sp. WH 8102], gi\|33632917\|emb\|CAE...	231.0	[0..2]	[186..7]
gi\|84512778, gi\|... - gi\|84518029\|ref\|ZP_01005378.1\| thioredoxin peroxidase [Prochlorococcus marinus str. MIT 9211], gi\|84...	231.0	[0..3]	[186..7]
gi\|33634943, gi\|... - gi\|33863026\|ref\|NP_894586.1\| thioredoxin peroxidase [Prochlorococcus marinus str. MIT 9313], gi\|3363...	230.0	[0..2]	[186..7]
gi\|116068112, gi... - gi\|116074890\|ref\|ZP_01472151.1\| thioredoxin peroxidase [Synechococcus sp. RS9916], gi\|116068112\|gb\|E...	229.0	[0..2]	[186..7]
gi\|86167507, gi\|... - gi\|87124628\|ref\|ZP_01080476.1\| thioredoxin peroxidase [Synechococcus sp. RS9917], gi\|86167507\|gb\|EAQ...	228.0	[0..2]	[186..7]
gi\|78197313, gi\|... - gi\|78212854\|ref\|YP_381633.1\| thioredoxin peroxidase [Synechococcus sp. CC9605], gi\|78197313\|gb\|ABB35...	228.0	[0..2]	[186..7]
gi\|62901916 - gi\|62901916\|gb\|AAY18909.1\| thioredoxin peroxidase 1-like [synthetic construct]	227.0	[0..2]	[186..30]
PRDX2_CRIGR - Peroxiredoxin-2 OS=Cricetulus griseus GN=PRDX2 PE=2 SV=3	227.0	[0..4]	[186..8]

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Predicted Domain #1

Region A:
Residues: [1-187]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLINTKIKP FKNQAFKNGE FIEITEKDTE GRWSVFFFYP ADFTFVCPTE LGDVADHYEE  60
   61 LQKLGVDVYA VSTDTHFTHK AWHSSSETIA KIKYAMIGDP TGALTRNFDN MREDEGLADR 120
  121 ATFVVDPQGI IQAIEVTAEG IGRDASDLLR KIKAAQYVAS HPGEVCPAKW KEGEATLAPS 180
  181 LDLVGKI

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Detection Method:	PSI-BLAST
Confidence:	49.0
Match:	1yexA
Description:	Structural and biochemical analysis of the link between enzymatic activity and oligomerization in AhpC, a bacterial peroxiredoxin.
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
alkyl hydroperoxide reductase activity	4.29610283853788	bayes_pls_golite062009
antioxidant activity	3.66884588063322	bayes_pls_golite062009
peroxidase activity	3.43831566988273	bayes_pls_golite062009
oxidoreductase activity, acting on peroxide as acceptor	3.43831566988273	bayes_pls_golite062009
selenium binding	2.92496040718744	bayes_pls_golite062009
glutathione peroxidase activity	2.56524997297011	bayes_pls_golite062009
transcription regulator activity	2.30799114442278	bayes_pls_golite062009
peroxiredoxin activity	2.12777217096121	bayes_pls_golite062009
thioredoxin peroxidase activity	1.96134566495756	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors	1.8187537496904	bayes_pls_golite062009
protein disulfide oxidoreductase activity	1.47769936616412	bayes_pls_golite062009
disulfide oxidoreductase activity	1.32811008894503	bayes_pls_golite062009
transferase activity	1.26687471229876	bayes_pls_golite062009
binding	1.25802922431343	bayes_pls_golite062009
signal transducer activity	1.11518182894524	bayes_pls_golite062009
molecular transducer activity	1.11518182894524	bayes_pls_golite062009
catalytic activity	0.672192331361968	bayes_pls_golite062009
peptide binding	0.374493676068876	bayes_pls_golite062009
	0.359224524631956	bayes_pls_golite062009
protein binding	0.134341907247724	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: