YRC Public Data Repository - Protein Structure Prediction

Protein:	ODP1_ECOLI
Organism:	Escherichia coli
Length:	887 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ODP1_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|194420947, gi... - gi\|83584560\|ref\|ZP_00923233.1\| COG2609: Pyruvate dehydrogenase complex, dehydrogenase (E1) component... gi\|242375948, gi... - gi\|251783675\|ref\|YP_002997979.1\| hypothetical protein B21_00112 [Escherichia coli BL21], gi\|24237594... gi\|253972135, gi... - gi\|254160234\|ref\|YP_003043342.1\| pyruvate dehydrogenase subunit E1 [Escherichia coli B str. REL606],... gi\|254287037, gi... - gi\|254287037\|ref\|YP_003052785.1\| pyruvate dehydrogenase subunit E1 [Escherichia coli BL21(DE3)], gi\|...	842.0	[0..1]	[887..1]
gi\|218425556, gi... - gi\|218687992\|ref\|YP_002396204.1\| pyruvate dehydrogenase subunit E1 [Escherichia coli ED1a], gi\|21842... gi\|91070756, gi\|... - gi\|91209182\|ref\|YP_539168.1\| pyruvate dehydrogenase subunit E1 [Escherichia coli UTI89], gi\|91070756... gi\|110341924, gi... - gi\|110640332\|ref\|YP_668060.1\| pyruvate dehydrogenase subunit E1 [Escherichia coli 536], gi\|110341924... gi\|227838113, gi... - gi\|227884975\|ref\|ZP_04002780.1\| pyruvate dehydrogenase subunit E1 [Escherichia coli 83972], gi\|22783... gi\|191174235, gi... - gi\|75236917\|ref\|ZP_00720979.1\| COG2609: Pyruvate dehydrogenase complex, dehydrogenase (E1) component... gi\|237704269, gi... - gi\|237704269\|ref\|ZP_04534750.1\| pyruvate dehydrogenase subunit E1 [Escherichia sp. 3_2_53FAA], gi\|22... gi\|26246055, gi\|... - gi\|26246055\|ref\|NP_752094.1\| pyruvate dehydrogenase subunit E1 [Escherichia coli CFT073], gi\|2610645... gi\|117622401, gi... - gi\|117622401\|ref\|YP_851314.1\| pyruvate dehydrogenase subunit E1 [Escherichia coli APEC O1], gi\|11551... gi\|218557057, gi... - gi\|218557057\|ref\|YP_002389970.1\| pyruvate dehydrogenase subunit E1 [Escherichia coli S88], gi\|218363...	840.0	[0..1]	[887..1]
gi\|24050318, gi\|... - gi\|24111558\|ref\|NP_706068.1\| pyruvate dehydrogenase subunit E1 [Shigella flexneri 2a str. 301], gi\|2... gi\|30061680, gi\|... - gi\|30061680\|ref\|NP_835851.1\| pyruvate dehydrogenase subunit E1 [Shigella flexneri 2a str. 2457T], gi...	840.0	[0..1]	[887..1]
gi\|73854209, gi\|... - gi\|74310732\|ref\|YP_309151.1\| pyruvate dehydrogenase subunit E1 [Shigella sonnei Ss046], gi\|73854209\|...	840.0	[0..1]	[887..1]
gi\|75176537, gi\|... - gi\|75176537\|ref\|ZP_00696674.1\| COG2609: Pyruvate dehydrogenase complex, dehydrogenase (E1) component... gi\|82542717, gi\|... - gi\|82542717\|ref\|YP_406664.1\| pyruvate dehydrogenase subunit E1 [Shigella boydii Sb227], gi\|81244128\|...	840.0	[0..1]	[887..1]
gi\|81239668, gi\|... - gi\|82775520\|ref\|YP_401867.1\| pyruvate dehydrogenase subunit E1 [Shigella dysenteriae Sd197], gi\|8123...	839.0	[0..1]	[887..1]
gi\|110613723, gi... - gi\|110804175\|ref\|YP_687695.1\| pyruvate dehydrogenase subunit E1 [Shigella flexneri 5 str. 8401], gi\|...	839.0	[0..1]	[887..1]
ODP1_ECO57 - (P0AFG9) Pyruvate dehydrogenase E1 component (EC 1.2.4.1) ODP1_ECOLI - (P0AFG8) Pyruvate dehydrogenase E1 component (EC 1.2.4.1)	838.0	[0..2]	[887..1]
gi\|50122711, gi\|... - gi\|50122711\|ref\|YP_051878.1\| pyruvate dehydrogenase subunit E1 [Pectobacterium atrosepticum SCRI1043...	833.0	[0..1]	[887..1]

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Predicted Domain #1

Region A:
Residues: [1-887]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSERFPNDVD PIETRDWLQA IESVIREEGV ERAQYLIDQL LAEARKGGVN VAAGTGISNY  60
   61 INTIPVEEQP EYPGNLELER RIRSAIRWNA IMTVLRASKK DLELGGHMAS FQSSATIYDV 120
  121 CFNHFFRARN EQDGGDLVYF QGHISPGVYA RAFLEGRLTQ EQLDNFRQEV HGNGLSSYPH 180
  181 PKLMPEFWQF PTVSMGLGPI GAIYQAKFLK YLEHRGLKDT SKQTVYAFLG DGEMDEPESK 240
  241 GAITIATREK LDNLVFVINC NLQRLDGPVT GNGKIINELE GIFEGAGWNV IKVMWGSRWD 300
  301 ELLRKDTSGK LIQLMNETVD GDYQTFKSKD GAYVREHFFG KYPETAALVA DWTDEQIWAL 360
  361 NRGGHDPKKI YAAFKKAQET KGKATVILAH TIKGYGMGDA AEGKNIAHQV KKMNMDGVRH 420
  421 IRDRFNVPVS DADIEKLPYI TFPEGSEEHT YLHAQRQKLH GYLPSRQPNF TEKLELPSLQ 480
  481 DFGALLEEQS KEISTTIAFV RALNVMLKNK SIKDRLVPII ADEARTFGME GLFRQIGIYS 540
  541 PNGQQYTPQD REQVAYYKED EKGQILQEGI NELGAGCSWL AAATSYSTNN LPMIPFYIYY 600
  601 SMFGFQRIGD LCWAAGDQQA RGFLIGGTSG RTTLNGEGLQ HEDGHSHIQS LTIPNCISYD 660
  661 PAYAYEVAVI MHDGLERMYG EKQENVYYYI TTLNENYHMP AMPEGAEEGI RKGIYKLETI 720
  721 EGSKGKVQLL GSGSILRHVR EAAEILAKDY GVGSDVYSVT SFTELARDGQ DCERWNMLHP 780
  781 LETPRVPYIA QVMNDAPAVA STDYMKLFAE QVRTYVPADD YRVLGTDGFG RSDSRENLRH 840
  841 HFEVDASYVV VAALGELAKR GEIDKKVVAD AIAKFNIDAD KVNPRLA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1000.0
Match:	2qtaA
Description:	No description for 2qtaA was found.

Predicted functions:

Term	Confidence	Notes
pyruvate dehydrogenase activity	11.3856674722026	bayes_pls_golite062009
pyruvate dehydrogenase (acetyl-transferring) activity	11.0549577473177	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	10.8180381281695	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	4.89064211833637	bayes_pls_golite062009
acetolactate synthase activity	1.59303412812463	bayes_pls_golite062009
transferase activity, transferring acyl groups	0.723020204729919	bayes_pls_golite062009
catalytic activity	0.545407789079971	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: