YRC Public Data Repository - Protein Structure Prediction

Protein:	PNCB_SALTI
Organism:	Salmonella enterica subsp. enterica serovar Typhi
Length:	400 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PNCB_SALTI.

Description	E-value	Query Range	Subject Range
gi\|110614488, gi... - gi\|110804940\|ref\|YP_688460.1\| nicotinate phosphoribosyltransferase [Shigella flexneri 5 str. 8401], ... gi\|170020667, gi... - gi\|170020667\|ref\|YP_001725621.1\| nicotinate phosphoribosyltransferase [Escherichia coli ATCC 8739], ... gi\|24051204, gi\|... - ref\|NP_706850.1\| nicotinate phosphoribosyltransferase [Shigella flexneri 2a str. 301], gb\|AAN42557.... gi\|124499410, gi... - gi\|124530123\|ref\|ZP_01700893.1\| nicotinate phosphoribosyltransferase [Escherichia coli B], gi\|124499...	0.0	[1..400]	[17..416]
gi\|194438710, gi... - gi\|83585874\|ref\|ZP_00924514.1\| COG1488: Nicotinic acid phosphoribosyltransferase [Escherichia coli 1... gi\|30062466, gi\|... - gi\|30062466\|ref\|NP_836637.1\| nicotinate phosphoribosyltransferase [Shigella flexneri 2a str. 2457T],... PNCB_ECO24 - Nicotinate phosphoribosyltransferase OS=Escherichia coli O139:H28 (strain E24377A / ETEC) GN=pncB PE... gi\|251784473, gi... - gi\|251784473\|ref\|YP_002998777.1\| hypothetical protein B21_00942 [Escherichia coli BL21], gi\|24237674... gi\|254161045, gi... - gi\|254161045\|ref\|YP_003044153.1\| nicotinate phosphoribosyltransferase [Escherichia coli B str. REL60... gi\|253977160, gi... - gi\|254287853\|ref\|YP_003053601.1\| nicotinate phosphoribosyltransferase [Escherichia coli BL21(DE3)], ... PNCB_ECO55 - Nicotinate phosphoribosyltransferase OS=Escherichia coli (strain 55989 / EAEC) GN=pncB PE=3 SV=1 PNCB_ECOSE - Nicotinate phosphoribosyltransferase OS=Escherichia coli (strain SE11) GN=pncB PE=3 SV=1 PNCB_ECO8A - Nicotinate phosphoribosyltransferase OS=Escherichia coli O8 (strain IAI1) GN=pncB PE=3 SV=1 gi\|190903000, gi... - gi\|75229863\|ref\|ZP_00716386.1\| COG1488: Nicotinic acid phosphoribosyltransferase [Escherichia coli B... PNCB_SHISS - Nicotinate phosphoribosyltransferase OS=Shigella sonnei (strain Ss046) GN=pncB PE=3 SV=1 PNCB_ECOHS - Nicotinate phosphoribosyltransferase OS=Escherichia coli O9:H4 (strain HS) GN=pncB PE=3 SV=1 PNCB_SHIFL - Nicotinate phosphoribosyltransferase OS=Shigella flexneri GN=pncB PE=3 SV=4 gi\|75214729, gi\|... - gi\|75214729\|ref\|ZP_00713234.1\| COG1488: Nicotinic acid phosphoribosyltransferase [Escherichia coli E... PNCB_SHIBS - Nicotinate phosphoribosyltransferase OS=Shigella boydii serotype 4 (strain Sb227) GN=pncB PE=3 SV=1 gi\|56383326, gi\|... - gi\|56479775\|ref\|NP_706850.2\| nicotinate phosphoribosyltransferase [Shigella flexneri 2a str. 301], g...	0.0	[1..400]	[1..400]
PNCB_SHIB3 - Nicotinate phosphoribosyltransferase OS=Shigella boydii serotype 18 (strain CDC 3083-94 / BS512) GN=...	0.0	[1..400]	[1..400]
PNCB_ECOBW - Nicotinate phosphoribosyltransferase OS=Escherichia coli (strain K12 / MC4100 / BW2952) GN=pncB PE=3... PNCB_ECOLI - Nicotinate phosphoribosyltransferase (EC 2.4.2.11) (NAPRTase) - Escherichia coli gi\|1651456, gi\|8... - gi\|89107781\|ref\|AP_001561.1\| nicotinate phosphoribosyltransferase [Escherichia coli str. K-12 substr... EG10742 - nicotinate phosphoribosyltransferase / Nicotinate phosphoribosyltransferase EG10742 - nicotinate phosphoribosyltransferase / Nicotinate phosphoribosyltransferase PNCB_ECODH - Nicotinate phosphoribosyltransferase OS=Escherichia coli (strain K12 / DH10B) GN=pncB PE=3 SV=1	0.0	[1..400]	[1..400]
gi\|194434382, gi... - gi\|83569157\|ref\|ZP_00920616.1\| COG1488: Nicotinic acid phosphoribosyltransferase [Shigella dysenteri...	0.0	[1..400]	[1..400]
PNCB_SALPK - Nicotinate phosphoribosyltransferase OS=Salmonella paratyphi A (strain AKU_12601) GN=pncB PE=3 SV=1 PNCB_SALNS - Nicotinate phosphoribosyltransferase OS=Salmonella newport (strain SL254) GN=pncB PE=3 SV=1 PNCB_SALPA - Nicotinate phosphoribosyltransferase OS=Salmonella paratyphi A (strain ATCC 9150 / SARB42) GN=pncB P... PNCB_SALPB - Nicotinate phosphoribosyltransferase OS=Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7) GN=pncB... gi\|200390034, gi... - gi\|200390034\|ref\|ZP_03216645.1\| nicotinate phosphoribosyltransferase [Salmonella enterica subsp. ent... PNCB_SALPA - Nicotinate phosphoribosyltransferase OS=Salmonella paratyphi A GN=pncB PE=3 SV=1 PNCB_SALPB - Nicotinate phosphoribosyltransferase OS=Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7) GN=pncB...	0.0	[1..400]	[1..400]
gi\|193064666, gi... - gi\|75257352\|ref\|ZP_00728868.1\| COG1488: Nicotinic acid phosphoribosyltransferase [Escherichia coli E... gi\|75210378, gi\|... - gi\|75210378\|ref\|ZP_00710534.1\| COG1488: Nicotinic acid phosphoribosyltransferase [Escherichia coli B...	0.0	[1..400]	[1..400]
gi\|188488180, gi... - gi\|75512087\|ref\|ZP_00734672.1\| COG1488: Nicotinic acid phosphoribosyltransferase [Escherichia coli 5...	0.0	[1..400]	[1..400]
gi\|62127165, gi\|... - gi\|62179532\|ref\|YP_215949.1\| nicotinate phosphoribosyltransferase [Salmonella enterica subsp. enteri...	0.0	[1..400]	[17..416]
gi\|226898290, gi... - gi\|237707080\|ref\|ZP_04537561.1\| nicotinate phosphoribosyltransferase [Escherichia sp. 3_2_53FAA], gi... gi\|91071607, gi\|... - gi\|91210033\|ref\|YP_540019.1\| nicotinate phosphoribosyltransferase [Escherichia coli UTI89], gi\|91071... gi\|115512273, gi... - gi\|117623149\|ref\|YP_852062.1\| nicotinate phosphoribosyltransferase [Escherichia coli APEC O1], gi\|11...	0.0	[1..400]	[17..416]

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Predicted Domain #1

Region A:
Residues: [1-400]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTQFASPVLH SLLDTDAYKL HMQQAVFHHY YDVQVAAEFR CRGDDLLGIY ADAIREQVDA  60
   61 MQHLRLQEDE FQWLSGLPFF KPDYLNWLRE FRYNPAQVCV TNDNGKLNIR LTGSWREVIM 120
  121 WEVPLLAVIS ELVHHYRSPN AGVDQALDAL ESKLVDFTAL TANLDMSRFH LMDFGTRRRF 180
  181 SREVQQAIVK RLQQESWFVG TSNYDLARRL ALTPMGTQAH EWFQAHQQIN PDLATSQRAA 240
  241 LAAWLNEYPD QLGIALTDCI TMDAFLRDFG IEFASRYQGL RHDSGDPVAW GEKAIAHYEK 300
  301 LGIDPLTKTL VFSDNLDLPK AVELYRHFAS RVQLSFGIGT RLTCDIPQVK PLNIVIKLVE 360
  361 CNGKPVAKLS DSPGKTICHD KAFVRALRKA FDLPQVRKAS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	127.0
Match:	1yirA
Description:	Crystal Structure of a Nicotinate Phosphoribosyltransferase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
nicotinate phosphoribosyltransferase activity	5.75487746784842	bayes_pls_golite062009
transferase activity, transferring glycosyl groups	4.79136593406808	bayes_pls_golite062009
nicotinate-nucleotide diphosphorylase (carboxylating) activity	3.97201856258863	bayes_pls_golite062009
transferase activity, transferring pentosyl groups	3.41342374351311	bayes_pls_golite062009
catalytic activity	2.59603106157451	bayes_pls_golite062009
transferase activity	1.91642626258277	bayes_pls_golite062009
binding	1.73051405037757	bayes_pls_golite062009
protein binding	0.294646489785198	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: