YRC Public Data Repository - Protein Structure Prediction

Protein:	SYY_ECOLI
Organism:	Escherichia coli
Length:	424 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SYY_ECOLI.

Description	E-value	Query Range	Subject Range
SYY_SALCH - Tyrosine--tRNA ligase OS=Salmonella choleraesuis (strain SC-B67) GN=tyrS PE=3 SV=1 SYY_SALPA - Tyrosine--tRNA ligase OS=Salmonella paratyphi A (strain ATCC 9150 / SARB42) GN=tyrS PE=3 SV=1 lcl\|NC_016856.1_... - [gene=tyrS] [protein=tyrosyl-tRNA synthetase] [protein_id=YP_005237319.1] [location=1533463..1534737... SYY_SALTY - Tyrosine--tRNA ligase OS=Salmonella typhimurium GN=tyrS PE=3 SV=1 SYY_SALCH - Tyrosine--tRNA ligase OS=Salmonella choleraesuis GN=tyrS PE=3 SV=1 SYY_SALCH - Tyrosyl-tRNA synthetase OS=Salmonella choleraesuis GN=tyrS PE=3 SV=1 SYY_SALPA - Tyrosine--tRNA ligase OS=Salmonella paratyphi A GN=tyrS PE=3 SV=1 SYY_SALTY - Tyrosyl-tRNA synthetase OS=Salmonella typhimurium GN=tyrS PE=3 SV=1 SYY_SALTI - Tyrosyl-tRNA synthetase OS=Salmonella typhi GN=tyrS PE=3 SV=1 SYY_SALSV - Tyrosine--tRNA ligase OS=Salmonella schwarzengrund (strain CVM19633) GN=tyrS PE=3 SV=1 SYY_SALA4 - Tyrosine--tRNA ligase OS=Salmonella agona (strain SL483) GN=tyrS PE=3 SV=1 gi\|197239883, gi... - gi\|197261628\|ref\|ZP_03161702.1\| tyrosyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar... SYY_SALPK - Tyrosine--tRNA ligase OS=Salmonella paratyphi A (strain AKU_12601) GN=tyrS PE=3 SV=1 gi\|168819199, gi... - gi\|205343665\|gb\|EDZ30429.1\| tyrosyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar Wel... SYY_SALNS - Tyrosine--tRNA ligase OS=Salmonella newport (strain SL254) GN=tyrS PE=3 SV=1 SYY_SALHS - Tyrosine--tRNA ligase OS=Salmonella heidelberg (strain SL476) GN=tyrS PE=3 SV=1 gi\|194469349, gi... - gi\|194469349\|ref\|ZP_03075333.1\| tyrosyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar... gi\|238913150 - gi\|238913150\|ref\|ZP_04656987.1\| tyrosyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar... gi\|167994279, gi... - gi\|205327841\|gb\|EDZ14605.1\| tyrosyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar 4,[... gi\|168229823, gi... - gi\|205335458\|gb\|EDZ22222.1\| tyrosyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar Ken... gi\|168235521, gi... - gi\|197291166\|gb\|EDY30519.1\| tyrosyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar Sch... SYY_SALPB - Tyrosine--tRNA ligase OS=Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7) GN=tyrS PE=3 SV=1 gi\|168463140, gi... - gi\|195634532\|gb\|EDX52884.1\| tyrosyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar New... SYY_SALPB - Tyrosyl-tRNA synthetase OS=Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7) GN=tyrS PE=3 SV=1 gi\|205323596, gi... - gi\|205323596\|gb\|EDZ11435.1\| tyrosyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar Sai... SYY_SALTY - Tyrosine--tRNA ligase OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=tyrS PE=3 S... gi\|214000281 - gi\|214000281\|ref\|ZP_03411016.1\| tyrosyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar... gi\|29141776, gi\|... - gi\|29141776\|ref\|NP_805118.1\| tyrosyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar Ty... SYY_SALTI - Tyrosine--tRNA ligase OS=Salmonella typhi GN=tyrS PE=3 SV=1 gi\|213425988 - gi\|213425988\|ref\|ZP_03358738.1\| tyrosyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar... gi\|213622227 - gi\|213622227\|ref\|ZP_03375010.1\| tyrosyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar... gi\|16760464 - gi\|16760464\|ref\|NP_456081.1\| tyrosyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar Ty... gi\|213649176 - gi\|213649176\|ref\|ZP_03379229.1\| tyrosyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar... gi\|213857492 - gi\|213857492\|ref\|ZP_03384463.1\| tyrosyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar... SYY_SALDC - Tyrosine--tRNA ligase OS=Salmonella dublin (strain CT_02021853) GN=tyrS PE=3 SV=1 gi\|204927912, gi... - gi\|204927912\|ref\|ZP_03219113.1\| tyrosyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar... SYY_SALG2 - Tyrosine--tRNA ligase OS=Salmonella gallinarum (strain 287/91 / NCTC 13346) GN=tyrS PE=3 SV=1 gi\|205358968, gi... - gi\|205358968\|ref\|ZP_02665896.2\| tyrosyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar...	439.0	[0..1]	[424..1]
SYY_ECOL6 - Tyrosine--tRNA ligase OS=Escherichia coli O6 GN=tyrS PE=3 SV=3 SYY_ECOL6 - Tyrosine--tRNA ligase OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) GN=tyrS PE=3 SV... SYY_ECO27 - Tyrosine--tRNA ligase OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=tyrS PE=3 SV=1 SYY_ECO45 - Tyrosine--tRNA ligase OS=Escherichia coli O45:K1 (strain S88 / ExPEC) GN=tyrS PE=3 SV=1 SYY_ECO81 - Tyrosine--tRNA ligase OS=Escherichia coli O81 (strain ED1a) GN=tyrS PE=3 SV=1 sp\|B7URX8\|SYY_ECO27 - Tyrosyl-tRNA synthetase OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=tyrS PE=3 SV=1 SYY_ECO55 - Tyrosine--tRNA ligase OS=Escherichia coli (strain 55989 / EAEC) GN=tyrS PE=3 SV=1	437.0	[0..1]	[424..1]
gi\|30063152, gi\|... - gi\|30063152\|ref\|NP_837323.1\| tyrosyl-tRNA synthetase [Shigella flexneri 2a str. 2457T], gi\|30041401\|... gi\|194417461, gi... - gi\|194434313\|ref\|ZP_03066578.1\| tyrosyl-tRNA synthetase [Shigella dysenteriae 1012], gi\|194417461\|gb...	436.0	[0..1]	[424..1]
SYY_ECOK1 - Tyrosine--tRNA ligase OS=Escherichia coli O1:K1 / APEC GN=tyrS PE=3 SV=1 SYY_ECOUT - Tyrosine--tRNA ligase OS=Escherichia coli (strain UTI89 / UPEC) GN=tyrS PE=3 SV=1 gi\|227885946, gi... - gi\|227885946\|ref\|ZP_04003751.1\| tyrosyl-tRNA synthetase [Escherichia coli 83972], gi\|227837125\|gb\|EE... gi\|26247884, gi\|... - gi\|26247884\|ref\|NP_753924.1\| tyrosyl-tRNA synthetase [Escherichia coli CFT073], gi\|26108287\|gb\|AAN80...	435.0	[0..1]	[424..5]
gi\|75234950 - gi\|75234950\|ref\|ZP_00719229.1\| COG0162: Tyrosyl-tRNA synthetase [Escherichia coli E110019] gi\|75195717 - gi\|75195717\|ref\|ZP_00705787.1\| COG0162: Tyrosyl-tRNA synthetase [Escherichia coli HS] gi\|75190677 - gi\|75190677\|ref\|ZP_00703944.1\| COG0162: Tyrosyl-tRNA synthetase [Escherichia coli E24377A] gi\|75178466 - gi\|75178466\|ref\|ZP_00698512.1\| COG0162: Tyrosyl-tRNA synthetase [Shigella boydii BS512] gi\|25292889, gi\|... - gi\|25292889\|pir\|\|F85770 tyrosine tRNA synthetase [imported] - Escherichia coli (strain O157:H7, sub... gi\|75512930 - gi\|75512930\|ref\|ZP_00735411.1\| COG0162: Tyrosyl-tRNA synthetase [Escherichia coli 53638] gi\|15802051, gi\|... - gi\|15802051\|ref\|NP_288073.1\| tyrosyl-tRNA synthetase [Escherichia coli O157:H7 EDL933], gi\|12515629\|... gi\|75238802 - gi\|75238802\|ref\|ZP_00722786.1\| COG0162: Tyrosyl-tRNA synthetase [Escherichia coli F11]	435.0	[0..1]	[424..5]
gi\|75230914 - gi\|75230914\|ref\|ZP_00717363.1\| COG0162: Tyrosyl-tRNA synthetase [Escherichia coli B7A]	435.0	[0..1]	[424..5]
gi\|83569260 - gi\|83569260\|ref\|ZP_00920717.1\| COG0162: Tyrosyl-tRNA synthetase [Shigella dysenteriae 1012]	434.0	[0..1]	[424..5]
gi\|75257056 - gi\|75257056\|ref\|ZP_00728616.1\| COG0162: Tyrosyl-tRNA synthetase [Escherichia coli E22]	434.0	[0..1]	[424..5]
SYY_SHIDS - Tyrosine--tRNA ligase OS=Shigella dysenteriae serotype 1 (strain Sd197) GN=tyrS PE=3 SV=3	434.0	[0..1]	[424..1]
gi\|75212974 - gi\|75212974\|ref\|ZP_00712972.1\| COG0162: Tyrosyl-tRNA synthetase [Escherichia coli B171]	434.0	[0..1]	[424..5]

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Predicted Domain #1

Region A:
Residues: [1-319]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASSNLIKQL QERGLVAQVT DEEALAERLA QGPIALYCGF DPTADSLHLG HLVPLLCLKR  60
   61 FQQAGHKPVA LVGGATGLIG DPSFKAAERK LNTEETVQEW VDKIRKQVAP FLDFDCGENS 120
  121 AIAANNYDWF GNMNVLTFLR DIGKHFSVNQ MINKEAVKQR LNREDQGISF TEFSYNLLQG 180
  181 YDFACLNKQY GVVLQIGGSD QWGNITSGID LTRRLHQNQV FGLTVPLITK ADGTKFGKTE 240
  241 GGAVWLDPKK TSPYKFYQFW INTADADVYR FLKFFTFMSI EEINALEEED KNSGKAPRAQ 300
  301 YVLAEQVTRL VHGEEGLQA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	94.522879
Match:	1x8xA
Description:	Tyrosyl t-RNA Synthetase from E.coli Complexed with Tyrosine
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [320-424]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AKRITECLFS GSLSALSEAD FEQLAQDGVP MVEMEKGADL MQALVDSELQ PSRGQARKTI  60
   61 ASNAITINGE KQSDPEYFFK EEDRLFGRFT LLRRGKKNYC LICWK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	18.69897
Match:	1jh3A
Description:	Tyrosyl-trna synthetase (TyrRS), C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
structural constituent of ribosome	4.38130670432475	bayes_pls_golite062009
structural molecule activity	4.02543122782129	bayes_pls_golite062009
nucleic acid binding	0.926923419656671	bayes_pls_golite062009
binding	0.803280718980961	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: