YRC Public Data Repository - Protein Structure Prediction

Protein:	EG13940
Organism:	Escherichia coli K-12
Length:	287 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for EG13940.

Description	E-value	Query Range	Subject Range
gi\|106895590, gi... - gi\|158321715\|ref\|YP_001514222.1\| phosphomethylpyrimidine kinase [Alkaliphilus oremlandii OhILAs], gi...	229.0	[0..2]	[270..1]
gi\|149948927, gi... - gi\|77686688\|ref\|ZP_00802021.1\| Phosphomethylpyrimidine kinase [Alkaliphilus metalliredigenes QYMF], ...	228.0	[0..2]	[270..1]
gi\|218558507, gi... - gi\|218558507\|ref\|YP_002391420.1\| pyridoxamine kinase [Escherichia coli S88], gi\|218365276\|emb\|CAR029... gi\|218689583, gi... - gi\|218689583\|ref\|YP_002397795.1\| pyridoxamine kinase [Escherichia coli ED1a], gi\|218427147\|emb\|CAR08... gi\|75238803 - gi\|75238803\|ref\|ZP_00722787.1\| COG2240: Pyridoxal/pyridoxine/pyridoxamine kinase [Escherichia coli F... gi\|115512946, gi... - gi\|117623822\|ref\|YP_852735.1\| pyridoxamine kinase [Escherichia coli APEC O1], gi\|115512946\|gb\|ABJ010... PDXY_ECOUT - Pyridoxal kinase PdxY OS=Escherichia coli (strain UTI89 / UPEC) GN=pdxY PE=3 SV=3 PDXY_ECOL5 - Pyridoxal kinase PdxY OS=Escherichia coli O6:K15:H31 (strain 536 / UPEC) GN=pdxY PE=3 SV=2 gi\|226900337, gi... - gi\|237705580\|ref\|ZP_04536061.1\| pyridoxine kinase [Escherichia sp. 3_2_53FAA], gi\|226900337\|gb\|EEH86...	227.0	[0..1]	[287..1]
PDXY_SHIDS - Pyridoxal kinase PdxY OS=Shigella dysenteriae serotype 1 (strain Sd197) GN=pdxY PE=3 SV=3	227.0	[0..1]	[287..1]
gi\|227885947, gi... - gi\|227885947\|ref\|ZP_04003752.1\| pyridoxamine kinase [Escherichia coli 83972], gi\|227837126\|gb\|EEJ475... PDXY_ECOL6 - Pyridoxal kinase PdxY OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) GN=pdxY PE=3 SV... PDXY_ECOL6 - Pyridoxamine kinase OS=Escherichia coli O6 GN=pdxY PE=3 SV=3	227.0	[0..1]	[287..1]
gi\|218705137, gi... - gi\|218705137\|ref\|YP_002412656.1\| pyridoxamine kinase [Escherichia coli UMN026], gi\|218432234\|emb\|CAR... gi\|254592653, gi... - gi\|254793253\|ref\|YP_003078090.1\| pyridoxal kinase 2/pyridoxine kinase [Escherichia coli O157:H7 str.... gi\|13361812, gi\|... - gi\|15831599\|ref\|NP_310372.1\| pyridoxamine kinase [Escherichia coli O157:H7 str. Sakai], gi\|13361812\|... gi\|194434304, gi... - gi\|83569259\|ref\|ZP_00920716.1\| COG2240: Pyridoxal/pyridoxine/pyridoxamine kinase [Shigella dysenteri... gi\|25326117, gi\|... - pir\|\|E85770 pyridoxal kinase 2 / pyridoxine kinase [imported] - Escherichia coli (strain O157:H7, su... gi\|15802050, gi\|... - gi\|15802050\|ref\|NP_288072.1\| pyridoxamine kinase [Escherichia coli O157:H7 EDL933], gi\|12515628\|gb\|A... PDXY_ECO57 - Pyridoxal kinase PdxY OS=Escherichia coli O157:H7 GN=pdxY PE=3 SV=3 gi\|218369781, gi... - gi\|218699795\|ref\|YP_002407424.1\| pyridoxamine kinase [Escherichia coli IAI39], gi\|218369781\|emb\|CAR1... gi\|195939026 - gi\|195939026\|ref\|ZP_03084408.1\| pyridoxamine kinase [Escherichia coli O157:H7 str. EC4024]	226.0	[0..1]	[287..1]
gi\|110802744, gi... - gi\|110802744\|ref\|YP_698658.1\| phosphomethylpyrimidine kinase [Clostridium perfringens SM101], gi\|110...	226.0	[0..4]	[270..6]
gi\|18145000, gi\|... - gi\|18310320\|ref\|NP_562254.1\| phosphomethylpyrimidine kinase [Clostridium perfringens str. 13], gi\|18...	226.0	[0..4]	[270..6]
PDXY_SHIFL - Pyridoxal kinase PdxY OS=Shigella flexneri GN=pdxY PE=3 SV=3 gi\|24051992, gi\|... - gi\|24113026\|ref\|NP_707536.1\| pyridoxamine kinase [Shigella flexneri 2a str. 301], gi\|24051992\|gb\|AAN... gi\|30041400, gi\|... - gi\|30063151\|ref\|NP_837322.1\| pyridoxamine kinase [Shigella flexneri 2a str. 2457T], gi\|30041400\|gb\|A...	225.0	[0..1]	[287..1]
gi\|28211403, gi\|... - gi\|28211403\|ref\|NP_782347.1\| hydroxymethylpyrimidine kinase [Clostridium tetani E88], gi\|28203844\|gb...	225.0	[0..3]	[273..8]

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Predicted Domain #1

Region A:
Residues: [1-287]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMKNILAIQS HVVYGHAGNS AAEFPMRRLG ANVWPLNTVQ FSNHTQYGKW TGCVMPPSHL  60
   61 TEIVQGIAAI DKLHTCDAVL SGYLGSAEQG EHILGIVRQV KAANPQAKYF CDPVMGHPEK 120
  121 GCIVAPGVAE FHVRHGLPAS DIIAPNLVEL EILCEHAVNN VEEAVLAARE LIAQGPQIVL 180
  181 VKHLARAGYS RDRFEMLLVT ADEAWHISRP LVDFGMRQPV GVGDVTSGLL LVKLLQGATL 240
  241 QEALEHVTAA VYEIMVTTKA MQEYELQVVA AQDRIAKPEH YFSATKL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	58.522879
Match:	1td2A
Description:	Crystal Structure of the PdxY Protein from Escherichia coli
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
lithium ion binding	3.00550221878163	bayes_pls_golite062009
pyridoxal kinase activity	2.62798458074822	bayes_pls_golite062009
kinase activity	2.44230326483029	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	2.43969902311075	bayes_pls_golite062009
transferase activity	2.15883296431019	bayes_pls_golite062009
phosphomethylpyrimidine kinase activity	2.12104666683074	bayes_pls_golite062009
sodium ion binding	1.88404806163148	bayes_pls_golite062009
catalytic activity	1.74474587246986	bayes_pls_golite062009
carbohydrate kinase activity	1.32862180479506	bayes_pls_golite062009
binding	1.27381021020647	bayes_pls_golite062009
nucleic acid binding	1.23363144435362	bayes_pls_golite062009
transcription regulator activity	1.21529398967164	bayes_pls_golite062009
alkali metal ion binding	1.18018952731159	bayes_pls_golite062009
potassium ion binding	1.18018952731159	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	1.01768986812996	bayes_pls_golite062009
DNA binding	0.954497955488766	bayes_pls_golite062009
pyridoxal binding	0.652502098540269	bayes_pls_golite062009
transcription factor activity	0.376784274163604	bayes_pls_golite062009
protein binding	0.140211399655759	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: