YRC Public Data Repository - Protein Structure Prediction

Protein:	EG11325
Organism:	Escherichia coli K-12
Length:	891 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for EG11325.

Description	E-value	Query Range	Subject Range
gi\|218553832, gi... - gi\|218553832\|ref\|YP_002386745.1\| aconitate hydratase [Escherichia coli IAI1], gi\|218360600\|emb\|CAQ98... gi\|75230167, gi\|... - gi\|75230167\|ref\|ZP_00716668.1\| COG1048: Aconitase A [Escherichia coli B7A], gi\|191166680\|ref\|ZP_0302... gi\|218351583, gi... - gi\|218694851\|ref\|YP_002402518.1\| aconitate hydratase [Escherichia coli 55989], gi\|218351583\|emb\|CAU9...	1163.0	[0..1]	[891..1]
ACON1_ECOLI, tr\|... - Aconitate hydratase 1 - Escherichia coli (strain K12), Aconitate hydratase OS=Escherichia coli (stra... ACON1_ECOLI - Aconitate hydratase 1 (EC 4.2.1.3) (Citrate hydro-lyase 1) (Aconitase 1) - Escherichia coli gi\|89108122, gi\|... - gi\|89108122\|ref\|AP_001902.1\| aconitate hydratase 1 [Escherichia coli str. K-12 substr. W3110], gi\|17... gi\|170080955, gi... - gi\|170080955\|ref\|YP_001730275.1\| aconitate hydratase 1 [Escherichia coli str. K-12 substr. DH10B], g... gi\|169755286, gi... - gi\|170020358\|ref\|YP_001725312.1\| aconitate hydratase [Escherichia coli ATCC 8739], gi\|169755286\|gb\|A... gi\|238900511, gi... - gi\|238900511\|ref\|YP_002926307.1\| aconitate hydratase 1 [Escherichia coli BW2952], gi\|238859922\|gb\|AC... gi\|242377056, gi... - gi\|251784783\|ref\|YP_002999087.1\| hypothetical protein B21_01264 [Escherichia coli BL21], gi\|24237705... gi\|83587414, gi\|... - gi\|83587414\|ref\|ZP_00926042.1\| COG1048: Aconitase A [Escherichia coli 101-1], gi\|194437004\|ref\|ZP_03... gi\|253773724, gi... - gi\|254288164\|ref\|YP_003053912.1\| aconitate hydratase [Escherichia coli BL21(DE3)], gi\|253977471\|gb\|A... gi\|157160783, gi... - gi\|75195425\|ref\|ZP_00705495.1\| COG1048: Aconitase A [Escherichia coli HS], gi\|157160783\|ref\|YP_00145... gi\|253973257, gi... - gi\|254161356\|ref\|YP_003044464.1\| aconitate hydratase [Escherichia coli B str. REL606], gi\|253973257\|...	1161.0	[0..1]	[891..1]
gi\|209911776, gi... - gi\|209918517\|ref\|YP_002292601.1\| aconitate hydratase [Escherichia coli SE11], gi\|209911776\|dbj\|BAG76... gi\|157154783, gi... - gi\|75190361\|ref\|ZP_00703628.1\| COG1048: Aconitase A [Escherichia coli E24377A], gi\|157154783\|ref\|YP_...	1161.0	[0..1]	[891..1]
gi\|75235217, gi\|... - gi\|75235217\|ref\|ZP_00719454.1\| COG1048: Aconitase A [Escherichia coli E110019], gi\|193069949\|ref\|ZP_...	1161.0	[0..1]	[891..1]
gi\|193062747, gi... - gi\|75259387\|ref\|ZP_00730706.1\| COG1048: Aconitase A [Escherichia coli E22], gi\|193062747\|ref\|ZP_0304... gi\|194415951, gi... - gi\|75212714\|ref\|ZP_00712712.1\| COG1048: Aconitase A [Escherichia coli B171], gi\|194425896\|ref\|ZP_030...	1161.0	[0..1]	[891..1]
gi\|75515111, gi\|... - gi\|75515111\|ref\|ZP_00737315.1\| COG1048: Aconitase A [Escherichia coli 53638], gi\|188494413\|ref\|ZP_03...	1161.0	[0..1]	[891..1]
gi\|227836494, gi... - gi\|227886290\|ref\|ZP_04004095.1\| aconitate hydratase [Escherichia coli 83972], gi\|227836494\|gb\|EEJ469... gi\|26247609, gi\|... - gi\|26247609\|ref\|NP_753649.1\| aconitate hydratase [Escherichia coli CFT073], gi\|26108011\|gb\|AAN80211....	1160.0	[0..1]	[891..1]
gi\|24112675, gi\|... - gi\|24112675\|ref\|NP_707185.1\| aconitate hydratase [Shigella flexneri 2a str. 301], gi\|24051590\|gb\|AAN... gi\|30041046, gi\|... - gi\|30062798\|ref\|NP_836969.1\| aconitate hydratase [Shigella flexneri 2a str. 2457T], gi\|30041046\|gb\|A...	1160.0	[0..1]	[891..1]
sp\|Q8ZP52\|ACNA_SALTY - Aconitate hydratase A OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=acnA PE=1 S... ACNA_SALTY - Aconitate hydratase A OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=acnA PE=1 S... gi\|197241536, gi... - gi\|197263281\|ref\|ZP_03163355.1\| aconitate hydratase 1 [Salmonella enterica subsp. enterica serovar S... gi\|194444825, gi... - gi\|194444825\|ref\|YP_002040963.1\| aconitate hydratase 1 [Salmonella enterica subsp. enterica serovar ... lcl\|NC_016856.1_... - [gene=acnA] [protein=aconitate hydratase] [protein_id=YP_005237634.1] [location=complement(1815444..... gi\|194406943, gi... - gi\|194448639\|ref\|YP_002045756.1\| aconitate hydratase [Salmonella enterica subsp. enterica serovar He... gi\|205328277, gi... - gi\|205328277\|gb\|EDZ15041.1\| aconitate hydratase 1 [Salmonella enterica subsp. enterica serovar 4,[5]... gi\|205339644, gi... - gi\|205339644\|gb\|EDZ26408.1\| aconitate hydratase 1 [Salmonella enterica subsp. enterica serovar Heide... gi\|167549786, gi... - gi\|205325020\|gb\|EDZ12859.1\| aconitate hydratase 1 [Salmonella enterica subsp. enterica serovar Saint...	1160.0	[0..1]	[890..1]
gi\|110614827, gi... - gi\|110805279\|ref\|YP_688799.1\| aconitate hydratase [Shigella flexneri 5 str. 8401], gi\|110614827\|gb\|A...	1160.0	[0..1]	[891..1]

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Predicted Domain #1

Region A:
Residues: [1-891]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSTLREASK DTLQAKDKTY HYYSLPLAAK SLGDITRLPK SLKVLLENLL RWQDGNSVTE  60
   61 EDIHALAGWL KNAHADREIA YRPARVLMQD FTGVPAVVDL AAMREAVKRL GGDTAKVNPL 120
  121 SPVDLVIDHS VTVDRFGDDE AFEENVRLEM ERNHERYVFL KWGKQAFSRF SVVPPGTGIC 180
  181 HQVNLEYLGK AVWSELQDGE WIAYPDTLVG TDSHTTMING LGVLGWGVGG IEAEAAMLGQ 240
  241 PVSMLIPDVV GFKLTGKLRE GITATDLVLT VTQMLRKHGV VGKFVEFYGD GLDSLPLADR 300
  301 ATIANMSPEY GATCGFFPID AVTLDYMRLS GRSEDQVELV EKYAKAQGMW RNPGDEPIFT 360
  361 STLELDMNDV EASLAGPKRP QDRVALPDVP KAFAASNELE VNATHKDRQP VDYVMNGHQY 420
  421 QLPDGAVVIA AITSCTNTSN PSVLMAAGLL AKKAVTLGLK RQPWVKASLA PGSKVVSDYL 480
  481 AKAKLTPYLD ELGFNLVGYG CTTCIGNSGP LPDPIETAIK KSDLTVGAVL SGNRNFEGRI 540
  541 HPLVKTNWLA SPPLVVAYAL AGNMNINLAS EPIGHDRKGD PVYLKDIWPS AQEIARAVEQ 600
  601 VSTEMFRKEY AEVFEGTAEW KGINVTRSDT YGWQEDSTYI RLSPFFDEMQ ATPAPVEDIH 660
  661 GARILAMLGD SVTTDHISPA GSIKPDSPAG RYLQGRGVER KDFNSYGSRR GNHEVMMRGT 720
  721 FANIRIRNEM VPGVEGGMTR HLPDSDVVSI YDAAMRYKQE QTPLAVIAGK EYGSGSSRDW 780
  781 AAKGPRLLGI RVVIAESFER IHRSNLIGMG ILPLEFPQGV TRKTLGLTGE EKIDIGDLQN 840
  841 LQPGATVPVT LTRADGSQEV VPCRCRIDTA TELTYYQNDG ILHYVIRNML K

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1000.0
Match:	2b3xA
Description:	Structure of an orthorhombic crystal form of human cytosolic aconitase (IRP1)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
3-isopropylmalate dehydratase activity	11.6597692115322	bayes_pls_golite062009
aconitate hydratase activity	5.86356477922338	bayes_pls_golite062009
structural constituent of ribosome	5.49717480487827	bayes_pls_golite062009
structural molecule activity	5.20352686802457	bayes_pls_golite062009
catalytic activity	2.4040324437254	bayes_pls_golite062009
mRNA binding	2.2758554402042	bayes_pls_golite062009
nucleic acid binding	2.25736437672211	bayes_pls_golite062009
carbon-oxygen lyase activity	2.08349115784849	bayes_pls_golite062009
hydro-lyase activity	2.04845291489052	bayes_pls_golite062009
lyase activity	2.0080619912194	bayes_pls_golite062009
RNA binding	2.00311670878109	bayes_pls_golite062009
metal cluster binding	1.70706327499066	bayes_pls_golite062009
iron-sulfur cluster binding	1.70706327499066	bayes_pls_golite062009
binding	1.67914740974449	bayes_pls_golite062009
DNA binding	1.6436451615422	bayes_pls_golite062009
iron-responsive element binding	1.1980380564483	bayes_pls_golite062009
iron ion binding	1.12961684198784	bayes_pls_golite062009
4 iron, 4 sulfur cluster binding	1.11810757572823	bayes_pls_golite062009
transition metal ion binding	0.342428816025605	bayes_pls_golite062009
protein binding	0.232638130896339	bayes_pls_golite062009
cation binding	0.0272064751959212	bayes_pls_golite062009
metal ion binding	0.0272064751959212	bayes_pls_golite062009
ion binding	0.0228992031160024	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: