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View Structure Prediction Details

Protein: unc-62
Organism: Caenorhabditis elegans
Length: 490 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for unc-62.

Description E-value Query
Range
Subject
Range
unc-62 - homeobox protein status:Confirmed UniProt:Q9N5D6 protein_id:AAF39974.1
324.0 [0..1] [490..75]

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Predicted Domain #1
Region A:
Residues: [1-166]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGGAPTSTPM MHHEMGEAMK RDKESIYAHP LYPLLVLLFE KCELATSTPR DTSRDGSTSS  60
   61 DVCSSASFKD DLNEFVRHTQ ENADKQYYVP NPQLDQIMLQ SIQMLRFHLL ELEKVHELCD 120
  121 NFCNRYVVCL KGKMPLDIVG DERASSSQPP MSPGSMGHLG HSSSPS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [167-302]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAGGATPMHY PPPYEPQSVP LPENAGVMGG HPMEGSSMAY SMAGMAAAAA SSSSSSNQAG  60
   61 DHPLANGGTL HSTAGASQTL LPIAVSSPST CSSGGLRQDS TPLSGETPMG HANGNSMDSI 120
  121 SEAGDEFSVC GSNDDG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [303-386]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RDSVLSDSAN GSQNGKRKVP KVFSKEAITK FRAWLFHNLT HPYPSEEQKK QLAKETGLTI  60
   61 LQVNNWFINA RRRIVQPMID QNNR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 19.69897
Match: 1pufA
Description: Crystal Structure of HoxA9 and Pbx1 homeodomains bound to DNA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 1.62959077995642 bayes_pls_golite062009
binding 1.48969201384255 bayes_pls_golite062009
DNA binding 1.2137926921894 bayes_pls_golite062009
nucleic acid binding 1.02805703044131 bayes_pls_golite062009
transcription factor activity 0.89626527070971 bayes_pls_golite062009
sequence-specific DNA binding 0.06790788268651 bayes_pls_golite062009
protein binding 0.012115247005138 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [387-490]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AGRSGQMNVC KNRRRNRSEQ SPGPSPDSGS DSGANYSPDP SSLAASTAMP YPAEFYMQRT  60
   61 MPYGGFPSFT NPAMPFMNPM MGFQVAPTVD ALSQQWVDLS APHE

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle