YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|25286069
Organism:	Streptococcus pneumoniae
Length:	279 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|25286069.

Description	E-value	Query Range	Subject Range
gi\|227175834, gi... - gi\|227555047\|ref\|ZP_03985094.1\| dimethyladenosine transferase [Enterococcus faecalis HH22], gi\|22717... RSMA_ENTFA - Ribosomal RNA small subunit methyltransferase A OS=Enterococcus faecalis (strain ATCC 700802 / V583)... gi\|227074699, gi... - gi\|227517856\|ref\|ZP_03947905.1\| dimethyladenosine transferase [Enterococcus faecalis TX0104], gi\|227... KSGA_ENTFA, RSMA... - Ribosomal RNA small subunit methyltransferase A OS=Enterococcus faecalis GN=rsmA PE=3 SV=1, Dimethyl... gi\|238829852, gi... - gi\|238857491\|ref\|ZP_04647727.1\| dimethyladenosine transferase [Enterococcus faecalis TUSoD Ef11], gi...	258.0	[0..1]	[277..16]
gi\|89101161, gi\|... - gi\|89101161\|ref\|ZP_01173994.1\| dimethyladenosine transferase [Bacillus sp. NRRL B-14911], gi\|8908412...	254.0	[0..1]	[274..14]
RSMA_STRP2 - Ribosomal RNA small subunit methyltransferase A OS=Streptococcus pneumoniae serotype 2 (strain D39 /... gi\|168492040, gi... - gi\|183573705\|gb\|EDT94233.1\| dimethyladenosine transferase [Streptococcus pneumoniae CDC0288-04], gi\|... gi\|25286073 - gi\|25286073\|pir\|\|E98096 dimethyladenosine transferase (EC 2.1.1.-) [imported] - Streptococcus pneumo... RSMA_STRR6 - Ribosomal RNA small subunit methyltransferase A OS=Streptococcus pneumoniae (strain ATCC BAA-255 / R...	254.0	[0..1]	[279..12]
gi\|242244296, gi... - gi\|242244296\|ref\|ZP_04798733.1\| dimethyladenosine transferase [Streptococcus pneumoniae TCH8431/19A]... RSMA_STRPJ - Ribosomal RNA small subunit methyltransferase A OS=Streptococcus pneumoniae (strain ATCC 700669 / Sp... gi\|183571617, gi... - gi\|183571617\|gb\|EDT92145.1\| dimethyladenosine transferase [Streptococcus pneumoniae SP195], gi\|16848... KSGA_STRPN, RSMA... - Ribosomal RNA small subunit methyltransferase A OS=Streptococcus pneumoniae GN=rsmA PE=3 SV=2, Dimet... gi\|147929973, gi... - gi\|149021935\|ref\|ZP_01835922.1\| dimethyladenosine transferase [Streptococcus pneumoniae SP23-BS72], ... gi\|147928127, gi... - gi\|148993153\|ref\|ZP_01822719.1\| dimethyladenosine transferase [Streptococcus pneumoniae SP9-BS68], g... RSMA_STRPN - Ribosomal RNA small subunit methyltransferase A OS=Streptococcus pneumoniae serotype 4 (strain ATCC ... RSMA_STRZT - Ribosomal RNA small subunit methyltransferase A OS=Streptococcus pneumoniae (strain Taiwan19F-14) GN...	253.0	[0..1]	[279..12]
gi\|55737756 - gb\|AAV61398.1\| dimethyladenosine transferase (rRNA methylation) [Streptococcus thermophilus LMG 1831... RSMA_STRT2 - Ribosomal RNA small subunit methyltransferase A OS=Streptococcus thermophilus (strain ATCC BAA-250 /...	252.0	[0..1]	[279..12]
RSMA_STAS1 - Ribosomal RNA small subunit methyltransferase A OS=Staphylococcus saprophyticus subsp. saprophyticus...	251.0	[0..1]	[274..15]
RSMA_STRTD - Ribosomal RNA small subunit methyltransferase A OS=Streptococcus thermophilus (strain ATCC BAA-491 /...	251.0	[0..1]	[279..12]
gi\|55739674 - gb\|AAV63315.1\| dimethyladenosine transferase (rRNA methylation) [Streptococcus thermophilus CNRZ1066... RSMA_STRT1 - Ribosomal RNA small subunit methyltransferase A OS=Streptococcus thermophilus (strain CNRZ 1066) GN=...	250.0	[0..1]	[279..12]
RSMA_GEOKA - Ribosomal RNA small subunit methyltransferase A OS=Geobacillus kaustophilus (strain HTA426) GN=rsmA ... RSMA_GEOKA, KSGA... - Ribosomal RNA small subunit methyltransferase A OS=Geobacillus kaustophilus GN=rsmA PE=3 SV=1, Dimet...	249.0	[0..1]	[275..14]
RSMA_STRA3, KSGA... - Ribosomal RNA small subunit methyltransferase A OS=Streptococcus agalactiae serotype III GN=rsmA PE=... gi\|77159783, gi\|... - gi\|77414160\|ref\|ZP_00790325.1\| dimethyladenosine transferase [Streptococcus agalactiae 515], gi\|7715... RSMA_STRA3 - Ribosomal RNA small subunit methyltransferase A OS=Streptococcus agalactiae serotype III (strain NEM...	248.0	[0..1]	[279..12]

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Predicted Domain #1

Region A:
Residues: [1-279]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLERHGFTFK KSFGQNFLTD TNILQKIVDT AEIDDQVNVI EIGPGIGALT EFLAERAAQV  60
   61 MAFEIDHRLV PILADTLRDF DNVTVVNEDI LKVDLAQHIQ NFKNPDLPIK VVANLPYYIT 120
  121 TPILMHLIES GIPFCEFVVM MQKEVADRIS AQPNTKAYGS LSIAVQYYMT AKVAFIVPRT 180
  181 VFVPAPNVDS AILKMVRRPE PAVAVEDENF FFKVSKASFT HRRKTLWNNL TGYFGKTEEV 240
  241 KDKLTKALDQ AGLSPSVRGE ALSLAEFAGL ADALKGQGL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	55.69897
Match:	1qyrA
Description:	2.1 Angstrom Crystal structure of KsgA: A Universally Conserved Adenosine Dimethyltransferase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
methyltransferase activity	4.15445027778357	bayes_pls_golite062009
rRNA methyltransferase activity	4.09362182773099	bayes_pls_golite062009
N-methyltransferase activity	4.07806017452628	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	4.07153733729662	bayes_pls_golite062009
protein methyltransferase activity	3.92746815303714	bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity	3.39429041855776	bayes_pls_golite062009
RNA methyltransferase activity	3.07428840534971	bayes_pls_golite062009
histone methyltransferase activity	2.99461585647365	bayes_pls_golite062009
DNA-methyltransferase activity	2.43145108778901	bayes_pls_golite062009
protein-arginine N-methyltransferase activity	2.41876112831625	bayes_pls_golite062009
arginine N-methyltransferase activity	2.41876112831625	bayes_pls_golite062009
transferase activity	2.22303238506686	bayes_pls_golite062009
histone-arginine N-methyltransferase activity	2.04296107639729	bayes_pls_golite062009
transcription regulator activity	2.0187748912503	bayes_pls_golite062009
rRNA (guanine) methyltransferase activity	2.00108769169811	bayes_pls_golite062009
rRNA (adenine) methyltransferase activity	1.83964463328968	bayes_pls_golite062009
tRNA methyltransferase activity	1.76571145896453	bayes_pls_golite062009
rRNA (adenine-N6,N6-)-dimethyltransferase activity	1.75675289134467	bayes_pls_golite062009
protein-arginine omega-N monomethyltransferase activity	1.66871163498737	bayes_pls_golite062009
DNA binding	1.62092940557438	bayes_pls_golite062009
nucleic acid binding	1.31440474302645	bayes_pls_golite062009
catalytic activity	1.25333584501255	bayes_pls_golite062009
histone methyltransferase activity (H4-R3 specific)	1.1103522853299	bayes_pls_golite062009
binding	0.976078016260105	bayes_pls_golite062009
rRNA (uridine-2'-O-)-methyltransferase activity	0.90544396691236	bayes_pls_golite062009
protein-arginine omega-N asymmetric methyltransferase activity	0.89325812193225	bayes_pls_golite062009
rRNA (uridine) methyltransferase activity	0.742142092552002	bayes_pls_golite062009
site-specific DNA-methyltransferase (adenine-specific) activity	0.703178429468566	bayes_pls_golite062009
tRNA (cytosine)-methyltransferase activity	0.672282175551951	bayes_pls_golite062009
tRNA (cytosine-5-)-methyltransferase activity	0.672282175551951	bayes_pls_golite062009
mitochondrial transcription initiation factor activity	0.481383105532041	bayes_pls_golite062009
RNA binding	0.417524996559564	bayes_pls_golite062009
rRNA (guanine-N1-)-methyltransferase activity	0.234572322347698	bayes_pls_golite062009
tRNA (adenine-N1-)-methyltransferase activity	0.0803947886180681	bayes_pls_golite062009
tRNA (adenine)-methyltransferase activity	0.0803947886180681	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: